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Arachidonic Acid Activates K+-Cl--cotransport in HepG2 Human Hepatoblastoma Cells

Lee YS

K+-Cl--cotransport (KCC) has been reported to have various cellular functions, including proliferation and apoptosis of human cancer cells. However, the signal transduction pathways that control the activity of KCC are...
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The Influences of G Proteins, Ca2+, and K+ Channels on Electrical Field Stimulation in Cat Esophageal Smooth Muscle

Park JH, Kim HS, Park SY, Im C, Jeong JH, Kim IK, Sohn UD

NO released by myenteric neurons controls the off contraction induced by electrical field stimulation (EFS) in distal esophageal smooth muscle, but in the presence of nitric oxide synthase (NOS) inhibitor,...
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Downregulation of Angiotensin II-Induced 12-Lipoxygenase Expression and Cell Proliferation in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats by CCL5

Kim JH, Kim HS

Angiotensin II (Ang II) plays an important role in vascular hypertension. The role of the chemokine CCL5 on Ang II-induced activities in vascular smooth muscle cells (VSMCs) has not been...
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Preventing Extracellular Diffusion of Trigeminal Nitric Oxide Enhances Formalin-induced Orofacial Pain

Jung HS, Jeon HB, Jeon IS, Lee BJ, Yoo HW, Ahn DK, Youn DH

Nitric oxide (NO), a diffusible gas, is produced in the central nervous system, including the spinal cord dorsal horn and the trigeminal nucleus, the first central areas processing nociceptive information...
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Optimized Immunohistochemical Analysis of Cerebellar Purkinje Cells Using a Specific Biomarker, Calbindin D28k

Kim BJ, Lee SY, Kim HW, Park EJ, Kim J, Kim SJ, So I, Jeon JH

Cerebellar Purkinje cells (PCs) play a crucial role in motor functions and their progressive degeneration is closely associated with spinocerebellar ataxias. Although immunohistochemical (IHC) analysis can provide a valuable tool...
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Comparison of Parametric and Bootstrap Method in Bioequivalence Test

Ahn BJ, Yim DS

The estimation of 90% parametric confidence intervals (CIs) of mean AUC and Cmax ratios in bioequivalence (BE) tests are based upon the assumption that formulation effects in log-transformed data are...
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Possible Involvement of Ca2+ Activated K+ Channels, SK Channel, in the Quercetin-Induced Vasodilatation

Nishida S, Satoh H

Effects of quercetin, a kind of flavonoids, on the vasodilating actions were investigated. Among the mechanisms for quercetin-induced vasodilatation in rat aorta, the involvement with the Ca2+ activated K+ (KCa)...
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Social Isolation Selectively Increases Anxiety in Mice without Affecting Depression-like Behavior

Kwak C, Lee SH, Kaang BK

It is hypothesized that a number of environmental factors affect animals' behavior. Without controlling these variables, it is very hard for researchers to get not only reliable, but replicable data...
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Ape1/Ref-1 Stimulates GDNF/GFR alpha1-mediated Downstream Signaling and Neuroblastoma Proliferation

Kang MY, Kim KY, Yoon Y, Kang Y, Kim HB, Youn CK, Kim DH, Kim MH

We previously reported that glial cell line-derived neurotropic factor (GDNF) receptor alpha1 (GFR alpha1) is a direct target of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1). In the present study, we further analyzed...
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Ser1778 of 53BP1 Plays a Role in DNA Double-strand Break Repairs

Lee JH, Cheong HM, Kang MY, Kim SY, Kang Y

53BP1 is an important genome stability regulator, which protects cells against double-strand breaks. Following DNA damage, 53BP1 is rapidly recruited to sites of DNA breakage, along with other DNA damage...
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Increase of NADPH-diaphorase Expression in Hypothalamus of Stat4 Knockout Mice

Hong MS, Song JY, Yun DH, Cho JJ, Chung JH

Signal transducer and activator of transcription 4 (STAT4), a STAT family member, mediates interleukin 12 (IL12) signal transduction. IL12 is known to be related to calorie-restricted status. In the central...
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