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Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Shin TK, Kang MS, Lee HY, Seo MS, Kim SG, Kim CD, Lee WS

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):257-263.
  • doi: 10.4196/kjpp.2009.13.3.257
This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically...
Bis Is Involved in Glial Differentiation of P19 Cells Induced by Retinoic Acid

Yoon JS, Lee MY, Lee JS, Park CS, Youn HJ, Lee JH

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):251-256.
  • doi: 10.4196/kjpp.2009.13.3.251
Previous observations suggest that Bis, a Bcl-2-binding protein, may play a role the neuronal and glial differentiation in vivo. To examine this further, we investigated Bis expression during the in...
Role of T-type Ca2+ Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle

Lee SE, Ahn DS, Lee YH

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):241-249.
  • doi: 10.4196/kjpp.2009.13.3.241
Although extracellular Ca2+ entry through the voltage-dependent Ca2+ channels plays an important role in the spontaneous phasic contractions of the pregnant rat myometrium, the role of the T-type Ca2+ channels...
Provinol Inhibits Catecholamine Secretion from the Rat Adrenal Medulla

Lee JH, Seo YS, Lim DY

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):229-239.
  • doi: 10.4196/kjpp.2009.13.3.229
The aim of the present study was to examine the effect of provinol, which is a mixture of polyphenolic compounds from red wine, on the secretion of catecholamines (CA) from...
Accurate Representation of Light-intensity Information by the Neural Activities of Independently Firing Retinal Ganglion Cells

Ryu SB, Ye JH, Kim CH, Goo YS, Kim KH

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):221-227.
  • doi: 10.4196/kjpp.2009.13.3.221
For successful restoration of visual function by a visual neural prosthesis such as retinal implant, electrical stimulation should evoke neural responses so that the information on visual input is properly...
Block of hERG K+ Channel by Classic Histamine H1 Receptor Antagonist Chlorpheniramine

Hong HK, Jo SH

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):215-220.
  • doi: 10.4196/kjpp.2009.13.3.215
Chlorpheniramine is a potent first-generation histamine H1 receptor antagonist that can increase action potential duration and induce QT prolongation in several animal models. Since block of cardiac human ether-a-go-go-related gene...
Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum

Jeun SH, Cho HS, Kim KJ, Li QZ, Sung KW

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):209-214.
  • doi: 10.4196/kjpp.2009.13.3.209
The striatum receives glutamatergic afferents from the cortex and thalamus, and these synaptic transmissions are mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and N-methyl-D-aspartate (NMDA) receptors. The purpose of this study was to...
Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway

Baek I, Jeon SB, Song MJ, Yang E, Sohn UD, Kim IK

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):201-207.
  • doi: 10.4196/kjpp.2009.13.3.201
Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular...
Zinc Inhibits Amyloid beta Production from Alzheimer's Amyloid Precursor Protein in SH-SY5Y Cells

Lee J, Kim CH, Kim DG, Ahn YS

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):195-200.
  • doi: 10.4196/kjpp.2009.13.3.195
Zinc released from excited glutamatergic neurons accelerates amyloid beta (A beta) aggregation, underscoring the therapeutic potential of zinc chelation for the treatment of Alzheimer's disease (AD). Zinc can also alter...
Forskolin Changes the Relationship between Cytosolic Ca2+ and Contraction in Guinea Pig Ileum

Han KH, Cheon GJ, Yeon DS, Kwon SC

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):189-194.
  • doi: 10.4196/kjpp.2009.13.3.189
This study was designed to clarify the mechanism of the inhibitory effect of forskolin on contraction, cytosolic Ca2+ level ([Ca2+]i), and Ca2+ sensitivity in guinea pig ileum. Forskolin (0.1 nM~10...
Ischemia/reperfusion Lung Injury Increases Serum Ferritin and Heme Oxygenase-1 in Rats

Park YY

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):181-187.
  • doi: 10.4196/kjpp.2009.13.3.181
Intestinal ischemia/reperfusion (I/R) is one of common causes of acute lung injury (ALI). Early and accurate diagnosis of patients who are like to develop serious acute respiratory distress syndrome (ARDS)...
P2X7 Receptor-mediated Membrane Blebbing in Salivary Epithelial Cells

Hwang SM, Koo NY, Choi SY, Chun GS, Kim JS, Park K

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):175-179.
  • doi: 10.4196/kjpp.2009.13.3.175
High concentrations of ATP induce membrane blebbing. However, the underlying mechanism involved in epithelial cells remains unclear. In this study, we investigated the role of the P2X7 receptor (P2X7R) in...
Immunomodulatory Activity of Ginsan, a Polysaccharide of Panax Ginseng, on Dendritic Cells

Kim MH, Byon YY, Ko EJ, Song JY, Yun YS, Shin T, Joo HG

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):169-173.
  • doi: 10.4196/kjpp.2009.13.3.169
Ginsan, a Panax ginseng polysaccharide that contains glucopyranoside and fructofuranoside, has immunomodulatory effects. Although several biologic studies of ginsan have been performed, its effects on dendritic cells (DCs), which are...
Extracellular Signal-regulated Kinase Activation Is Required for Serine 727 Phosphorylation of STAT3 in Schwann Cells in vitro and in vivo

Lee HK, Jung J, Lee SH, Seo SY, Suh DJ, Park HT

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):161-168.
  • doi: 10.4196/kjpp.2009.13.3.161
In the peripheral nerves, injury-induced cytokines and growth factors perform critical functions in the activation of both the MEK/ERK and JAK/STAT3 pathways. In this study, we determined that nerve injury-induced...
Deficiency of iNOS Does Not Prevent Isoproterenol-induced Cardiac Hypertrophy in Mice

Cha HN, Hong GR, Kim YW, Kim JY, Dan JM, Park SY

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):153-159.
  • doi: 10.4196/kjpp.2009.13.3.153
We investigated whether deficiency of inducible nitric oxide synthase (iNOS) could prevent isoproterenol-induced cardiac hypertrophy in iNOS knockout (KO) mice. Isoproterenol was continuously infused subcutaneously (15 mg/kg/day) using an osmotic...
Role of Dopamine Receptors on Electroencephalographic Changes Produced by Repetitive Apomorphine Treatments in Rats

Jang HS, Kim JY, Kim SH, Lee MG

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):147-151.
  • doi: 10.4196/kjpp.2009.13.3.147
Repeated psychostimulants induce electroencephalographic (EEG) changes, which reflect adaptation of the neural substrate related to dopaminergic pathways. To study the role of dopamine receptors in EEG changes, we examined the...
Water Extract of Samultang Reduces Apoptotic Cell Death by H2O2-Induced Oxidative Injury in SK-N-MC Cells

Lee GW, Kim MS

  • Korean J Physiol Pharmacol.
  • 2009 Jun;13(3):139-145.
  • doi: 10.4196/kjpp.2009.13.3.139
The purpose of this study was to evaluate the effects of the water extract of Samultang (SMT), a Chinese herb, on apoptotic cell death by H2O2-induced oxidative stress in SK-N-MC...

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