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P2X7 Receptor-mediated Membrane Blebbing in Salivary Epithelial Cells

Hwang SM, Koo NY, Choi SY, Chun GS, Kim JS, Park K

High concentrations of ATP induce membrane blebbing. However, the underlying mechanism involved in epithelial cells remains unclear. In this study, we investigated the role of the P2X7 receptor (P2X7R) in...
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Zinc Inhibits Amyloid beta Production from Alzheimer's Amyloid Precursor Protein in SH-SY5Y Cells

Lee J, Kim CH, Kim DG, Ahn YS

Zinc released from excited glutamatergic neurons accelerates amyloid beta (A beta) aggregation, underscoring the therapeutic potential of zinc chelation for the treatment of Alzheimer's disease (AD). Zinc can also alter...
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Water Extract of Samultang Reduces Apoptotic Cell Death by H2O2-Induced Oxidative Injury in SK-N-MC Cells

Lee GW, Kim MS

The purpose of this study was to evaluate the effects of the water extract of Samultang (SMT), a Chinese herb, on apoptotic cell death by H2O2-induced oxidative stress in SK-N-MC...
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Forskolin Changes the Relationship between Cytosolic Ca2+ and Contraction in Guinea Pig Ileum

Han KH, Cheon GJ, Yeon DS, Kwon SC

This study was designed to clarify the mechanism of the inhibitory effect of forskolin on contraction, cytosolic Ca2+ level ([Ca2+]i), and Ca2+ sensitivity in guinea pig ileum. Forskolin (0.1 nM~10...
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Block of hERG K+ Channel by Classic Histamine H1 Receptor Antagonist Chlorpheniramine

Hong HK, Jo SH

Chlorpheniramine is a potent first-generation histamine H1 receptor antagonist that can increase action potential duration and induce QT prolongation in several animal models. Since block of cardiac human ether-a-go-go-related gene...
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Ischemia/reperfusion Lung Injury Increases Serum Ferritin and Heme Oxygenase-1 in Rats

Park YY

Intestinal ischemia/reperfusion (I/R) is one of common causes of acute lung injury (ALI). Early and accurate diagnosis of patients who are like to develop serious acute respiratory distress syndrome (ARDS)...
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Accurate Representation of Light-intensity Information by the Neural Activities of Independently Firing Retinal Ganglion Cells

Ryu SB, Ye JH, Kim CH, Goo YS, Kim KH

For successful restoration of visual function by a visual neural prosthesis such as retinal implant, electrical stimulation should evoke neural responses so that the information on visual input is properly...
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Role of Dopamine Receptors on Electroencephalographic Changes Produced by Repetitive Apomorphine Treatments in Rats

Jang HS, Kim JY, Kim SH, Lee MG

Repeated psychostimulants induce electroencephalographic (EEG) changes, which reflect adaptation of the neural substrate related to dopaminergic pathways. To study the role of dopamine receptors in EEG changes, we examined the...
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Extracellular Signal-regulated Kinase Activation Is Required for Serine 727 Phosphorylation of STAT3 in Schwann Cells in vitro and in vivo

Lee HK, Jung J, Lee SH, Seo SY, Suh DJ, Park HT

In the peripheral nerves, injury-induced cytokines and growth factors perform critical functions in the activation of both the MEK/ERK and JAK/STAT3 pathways. In this study, we determined that nerve injury-induced...
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Role of T-type Ca2+ Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle

Lee SE, Ahn DS, Lee YH

Although extracellular Ca2+ entry through the voltage-dependent Ca2+ channels plays an important role in the spontaneous phasic contractions of the pregnant rat myometrium, the role of the T-type Ca2+ channels...
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Immunomodulatory Activity of Ginsan, a Polysaccharide of Panax Ginseng, on Dendritic Cells

Kim MH, Byon YY, Ko EJ, Song JY, Yun YS, Shin T, Joo HG

Ginsan, a Panax ginseng polysaccharide that contains glucopyranoside and fructofuranoside, has immunomodulatory effects. Although several biologic studies of ginsan have been performed, its effects on dendritic cells (DCs), which are...
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Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Shin TK, Kang MS, Lee HY, Seo MS, Kim SG, Kim CD, Lee WS

This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically...
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Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum

Jeun SH, Cho HS, Kim KJ, Li QZ, Sung KW

The striatum receives glutamatergic afferents from the cortex and thalamus, and these synaptic transmissions are mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and N-methyl-D-aspartate (NMDA) receptors. The purpose of this study was to...
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Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway

Baek I, Jeon SB, Song MJ, Yang E, Sohn UD, Kim IK

Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular...
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Deficiency of iNOS Does Not Prevent Isoproterenol-induced Cardiac Hypertrophy in Mice

Cha HN, Hong GR, Kim YW, Kim JY, Dan JM, Park SY

We investigated whether deficiency of inducible nitric oxide synthase (iNOS) could prevent isoproterenol-induced cardiac hypertrophy in iNOS knockout (KO) mice. Isoproterenol was continuously infused subcutaneously (15 mg/kg/day) using an osmotic...
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Provinol Inhibits Catecholamine Secretion from the Rat Adrenal Medulla

Lee JH, Seo YS, Lim DY

The aim of the present study was to examine the effect of provinol, which is a mixture of polyphenolic compounds from red wine, on the secretion of catecholamines (CA) from...
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Bis Is Involved in Glial Differentiation of P19 Cells Induced by Retinoic Acid

Yoon JS, Lee MY, Lee JS, Park CS, Youn HJ, Lee JH

Previous observations suggest that Bis, a Bcl-2-binding protein, may play a role the neuronal and glial differentiation in vivo. To examine this further, we investigated Bis expression during the in...
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