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10 results

Multiple Residues in the P-Region and M2 of Murine Kir 2.1 Regulate Blockage by External Ba2+

Lee YM, Thompson G, Ashmole I, Leyland M, So I, Stanfield

  • Korean J Physiol Pharmacol.
  • 2009 Feb;13(1):61-70.
  • doi: 10.4196/kjpp.2009.13.1.61
We have examined the effects of certain mutations of the selectivity filter and of the membrane helix M2 on Ba2+ blockage of the inward rectifier potassium channel, Kir 2.1. We...
Quantitative Structure Activity Relationship between Diazabicyclo[4.2.0]octanes Derivatives and Nicotinic Acetylcholine Receptor Agonists

Kim EA, Jung KC, Sohn UD, Im C

  • Korean J Physiol Pharmacol.
  • 2009 Feb;13(1):55-59.
  • doi: 10.4196/kjpp.2009.13.1.55
Three dimensional quantitative structure activity relationship between diazabicyclo[4.2.0]octanes and nicotinic acetylcholine receptor (h alpha4beta2 and h alpha3beta4) agonists was studied using comparative molecular field analysis (CoMFA) and comparative molecular similarity...
Antifungal and Anticancer Activities of a Protein from the Mushroom Cordyceps militaris

Park BT, Na KH, Jung EC, Park JW, Kim HH

  • Korean J Physiol Pharmacol.
  • 2009 Feb;13(1):49-54.
  • doi: 10.4196/kjpp.2009.13.1.49
The mushroom Cordyceps militaris has been used for a long time in eastern Asia as a nutraceutical and in traditional Chinese medicine as a treatment for cancer patients. In the...
Mechanisms of Selective Antimicrobial Activity of Gaegurin 4

Kim H, Lee BJ, Lee MH, Hong SG, Ryu PD

  • Korean J Physiol Pharmacol.
  • 2009 Feb;13(1):39-47.
  • doi: 10.4196/kjpp.2009.13.1.39
Gaegurin 4 (GGN4), an antimicrobial peptide isolated from a Korean frog, is five times more potent against Gram-positive than Gram-negative bacteria, but has little hemolytic activity. To understand the mechanism...
Effects of AIF on Knee Osteoarthritis Patients: Double-blind, Randomized Placebo-controlled Study

Park SH, Kim SK, Shin IH, Kim HG, Choe JY

  • Korean J Physiol Pharmacol.
  • 2009 Feb;13(1):33-37.
  • doi: 10.4196/kjpp.2009.13.1.33
Anti-inflammatory factor (AIF) is a water soluble extract of three herbs, Panax notoginseng (Burk.) F. H. Chen, Rehmannia glutinosa Libosch and Eleutherococcus senticosus. The present study aimed to investigate the...
Oxidized Low-density Lipoprotein- and Lysophosphatidylcholine-induced Ca2+ Mobilization in Human Endothelial Cells

Kim MY, Liang GH, Kim JA, Choi SS, Choi S, Suh SH

  • Korean J Physiol Pharmacol.
  • 2009 Feb;13(1):27-32.
  • doi: 10.4196/kjpp.2009.13.1.27
The effects of oxidized low-density lipoprotein (OxLDL) and its major lipid constituent lysophosphatidylcholine (LPC) on Ca2+ entry were investigated in cultured human umbilical endothelial cells (HUVECs) using fura-2 fluorescence and...
The Effect of Extracellular Glutamate Release on Repetitive Transient Ischemic Injury in Global Ischemia Model

Lee GJ, Choi SK, Eo YH, Kang SW, Choi S, Park JH, Lim JE, Hong KW, Jin HS, Oh BS, Park HK

  • Korean J Physiol Pharmacol.
  • 2009 Feb;13(1):23-26.
  • doi: 10.4196/kjpp.2009.13.1.23
During operations, neurosurgeons usually perform multiple temporary occlusions of parental artery, possibly resulting in the neuronal damage. It is generally thought that neuronal damage by cerebral ischemia is associated with...
Alterations in Membrane Transport Function and Cell Viability Induced by ATP Depletion in Primary Cultured Rabbit Renal Proximal Tubular Cells

Lee SJ, Kwon CH, Kim YK

  • Korean J Physiol Pharmacol.
  • 2009 Feb;13(1):15-22.
  • doi: 10.4196/kjpp.2009.13.1.15
This study was undertaken to elucidate the underlying mechanisms of ATP depletion-induced membrane transport dysfunction and cell death in renal proximal tubular cells. ATP depletion was induced by incubating cells...
P2 Receptor-mediated Inhibition of Vasopressin-stimulated Fluid Transport and cAMP Responses in AQP2-transfected MDCK Cells

Kim YH, Choi YJ, Bae HR, Woo JS

  • Korean J Physiol Pharmacol.
  • 2009 Feb;13(1):9-14.
  • doi: 10.4196/kjpp.2009.13.1.9
We cultured canine kidney (MDCK) cells stably expressing aquaporin-2 (AQP2) on collagen-coated permeable membrane filters and examined the effect of extracellular ATP on arginine vasopressin (AVP)-stimulated fluid transport and cAMP...
Changes of Atrial Natriuretic Peptide System in Rats with Puromycin Aminonucleoside-Induced Nephrotic Syndrome

Bae EH, Lee JU, Ma SK, Kim SW

  • Korean J Physiol Pharmacol.
  • 2009 Feb;13(1):1-7.
  • doi: 10.4196/kjpp.2009.13.1.1
Sodium retention is a hallmark of nephrotic syndrome. We investigated whether sodium retention is associated with changes of natriuretic peptide system at different stages (i.e., a sodium retaining stage and...

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