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9 results

Janus Kinase 2 Inhibitor AG490 Inhibits the STAT3 Signaling Pathway by Suppressing Protein Translation of gp130

Seo IA, Lee HK, Shin YK, Lee SH, Seo SY, Park JW, Park HT

  • Korean J Physiol Pharmacol.
  • 2009 Apr;13(2):131-138.
  • doi: 10.4196/kjpp.2009.13.2.131
The binding of interleukin-6 (IL-6) cytokine family ligands to the gp130 receptor complex activates the Janus kinase (JAK)/ signal transducer and activator of transcription 3 (STAT3) signal transduction pathway,...
Aprotinin Inhibits Vascular Smooth Muscle Cell Inflammation and Proliferation via Induction of HO-1

Lee DH, Choi HC, Lee KY, Kang YJ

  • Korean J Physiol Pharmacol.
  • 2009 Apr;13(2):123-129.
  • doi: 10.4196/kjpp.2009.13.2.123
Aprotinin is used clinically in cardiopulmonary bypass surgery to reduce transfusion requirements and the inflammatory response. The mechanism of action for the anti-inflammatory effects of aprotinin is still unclear....
Antitumor Effects of Camptothecin Combined with Conventional Anticancer Drugs on the Cervical and Uterine Squamous Cell Carcinoma Cell Line SiHa

Ha SW, Kim YJ, Kim W, Lee CS

  • Korean J Physiol Pharmacol.
  • 2009 Apr;13(2):115-121.
  • doi: 10.4196/kjpp.2009.13.2.115
Functional defects in mitochondria are involved in the induction of cell death in cancer cells. We assessed the toxic effect of camptothecin against the human cervical and uterine tumor...
Olibanum Extract Inhibits Vascular Smooth Muscle Cell Migration and Proliferation in Response to Platelet-Derived Growth Factor

Choi OB, Park JH, Lee YJ, Lee CK, Won KJ, Kim J, Lee HM, Kim B

  • Korean J Physiol Pharmacol.
  • 2009 Apr;13(2):107-113.
  • doi: 10.4196/kjpp.2009.13.2.107
Olibanum (Boswellia serrata) has been shown to have anti-inflammatory, anti-arthritic and anti- cancer effects. This study determined the role of a water extract of olibanum in platelet-derived growth factor (PDGF)-stimulated...
Cilostazol Attenuates 4-hydroxynonenal-enhanced CD36 Expression on Murine Macrophages via Inhibition of NADPH Oxidase-derived Reactive Oxygen Species Production

Yun MR, Park HM, Seo KW, Kim CE, Yoon JW, Kim CD

  • Korean J Physiol Pharmacol.
  • 2009 Apr;13(2):99-106.
  • doi: 10.4196/kjpp.2009.13.2.99
Although anti-atherogenic effects of cilostazol have been suggested, its effects on the expression of SR in macrophages are unclear. This study investigated the role of cilostazol on CD36 expression...
Microarray Analysis of Differentially Expressed Genes in the Brains of Tubby Mice

Lee JH, Kim CH, Kim DG, Ahn YS

  • Korean J Physiol Pharmacol.
  • 2009 Apr;13(2):91-97.
  • doi: 10.4196/kjpp.2009.13.2.91
The tubby mouse is characterized by progressive retinal and cochlear degeneration and late-onset obesity. These phenotypes are caused by a loss-of-function mutation in the tub gene and are shared with...
The Effects of Puerariae Flos on Stress-induced Deficits of Learning and Memory in Ovariectomized Female Rats

Park HJ, Han SM, Yoon WJ, Kim KS, Shim I

  • Korean J Physiol Pharmacol.
  • 2009 Apr;13(2):85-89.
  • doi: 10.4196/kjpp.2009.13.2.85
Puerariae flos (PF) is a traditional oriental medicinal plant and has clinically been prescribed for a long time. The purpose of the present study was to examine the effect of...
Maternal Social Separation of Adolescent Rats Induces Hyperactivity and Anxiolytic Behavior

Kwak HR, Lee JW, Kwon KJ, Kang CD, Cheong IY, Chun W, Kim SS, Lee HJ

  • Korean J Physiol Pharmacol.
  • 2009 Apr;13(2):79-83.
  • doi: 10.4196/kjpp.2009.13.2.79
Exposure to early stressful adverse life events such as maternal and social separation plays an essential role in the development of the nervous system. Adolescent Sprague-Dawley rats that were...
YKP1447, A Novel Potential Atypical Antipsychotic Agent

Dong SM, Kim YG, Heo J, Ji MK, Cho JW, Kwak BS

  • Korean J Physiol Pharmacol.
  • 2009 Apr;13(2):71-78.
  • doi: 10.4196/kjpp.2009.13.2.71
(S)-Carbamic acid 2-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-1-phenyl-ethyl ester hydrochloride (YKP1447) is a novel "atypical" antipsychotic drug which selectively binds to serotonin (5-HT2A, Ki=0.61 nM, 5-HT2C, Ki=20.7 nM) and dopamine (D2, Ki=45.9 nM, D3, Ki=42.1...

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