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The Inhibition of TREK2 Channel by an Oxidizing Agent, 5,5'-dithio- bis (2-nitrobenzoic acid), via Interaction with the C-terminus Distal to the 353rd Amino Acid

Park KS, Bang H, Shin EY, Kim CH, Kim Y

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):211-216.
  • doi: 10.4196/kjpp.2008.12.4.211
TREK (TWIK-RElated K+ channels) and TRAAK (TWIK-Related Arachidonic acid Activated K+ channels) were expressed in COS-7 cells, and the channel activities were recorded from inside-out membrane patches using holding potential...
Association between Interleukin 31 Receptor A Gene Polymorphism and Schizophrenia in Korean Population

Ban JY, Kim SK, Kim HJ, Chung JH, Kim T, Park JK, Park HK, Kim JW

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):205-209.
  • doi: 10.4196/kjpp.2008.12.4.205
Recently, Sun et al (2008) reported that the IL6R polymorphism is associated with schizophrenia. Therefore, to detect the association between polymorphisms of interleukin 31 receptor A (IL31RA) and schizophrenia, we...
Sorting Nexin 17 Interacts Directly with Kinesin Superfamily KIF1B beta Protein

Seog DH, Han J

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):199-204.
  • doi: 10.4196/kjpp.2008.12.4.199
KIF1B beta is a member of the Kinesin superfamily proteins (KIFs), which are microtubule-dependent molecular motors that are involved in various intracellular organellar transport processes. KIF1B beta is not restricted...
The Influence of Alpha-fetoprotein on Natural Suppressor Cell Activity and Ehrlich Carcinoma Growth

Belyaev NN, Bogdanov A, Savvulidi , Krasnoshtanov VK, Tleulieva , Alipov GK, Sekine I, Bae JS, Lee JB, Min YK, Yang HM

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):193-197.
  • doi: 10.4196/kjpp.2008.12.4.193
The influence of alpha-fetoprotein (AFP) on the bone marrow (BM) natural suppressor (NS) cells of intact Ehrlich carcinoma -bearing CBA mice was studied. Bone marrow NS cells were fractionated into...
Long-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death

Seok JH, Park KA, Byun HS, Won M, Shin S, Choi BL, Lee H, Kim YR, Hong JH, Park J, Hur GM

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):185-191.
  • doi: 10.4196/kjpp.2008.12.4.185
Activation of c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase family, is an important cellular response that modulates the outcome of the cells which are exposed to...
Acidic pH-activated Cl- Current and Intracellular Ca2+ Response in Human Keratinocytes

Park SJ, Choi WW, Kwon OS, Chung JH, Eun HC, Earm YE, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):177-183.
  • doi: 10.4196/kjpp.2008.12.4.177
The layers of keratinocytes form an acid mantle on the surface of the skin. Herein, we investigated the effects of acidic pH on the membrane current and [Ca2+](c) of human...
Roles of ERK and NF-kappa B in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells

Kang SH, Lee JH, Choi KH, Rhim BY, Kim K

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):171-176.
  • doi: 10.4196/kjpp.2008.12.4.171
Heat shock proteins (HSPs) serve as molecular chaperones and play a role in cell protection from damage in response to stress stimuli. The aim of this article is to investigate...
Synergistic Efficacy of Concurrent Treatment with Cilostazol and Probucol on the Suppression of Reactive Oxygen Species and Inflammatory Markers in Cultured Human Coronary Artery Endothelial Cells

Park SY, Lee JH, Shin HK, Kim CD, Lee WS, Rhim BY, Shin YW, Hong KW

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):165-170.
  • doi: 10.4196/kjpp.2008.12.4.165
In the present study, we aimed to identify the synergistic effects of concurrent treatment of low concentrations of cilostazol and probucol to inhibit the oxidative stress with suppression of inflammatory...
Resveratrol Inhibits Nicotinic Stimulation-Evoked Catecholamine Release from the Adrenal Medulla

Woo SC, Na GM, Lim DY

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):155-164.
  • doi: 10.4196/kjpp.2008.12.4.155
Resveratrol has been known to possess various potent cardiovascular effects in animal, but there is little information on its functional effect on the secretion of catecholamines (CA) from the perfused...
Expression of Endothelin-1 and Its Receptors in Cisplatin-Induced Acute Renal Failure in Mice

Lee S, Ahn D

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):149-153.
  • doi: 10.4196/kjpp.2008.12.4.149
Endothelin-1 (ET-1) is unequivocally elevated in the kidney with ischemic acute renal failure (ARF), whereas ET receptors (ET(A)R and ET(B)R) are variably expressed. Although renal functional and structural changes are...
Role of Caveolin-1 in Indomethacin-induced Death of Human Hepatoadenocarcinoma SK-Hep1 Cells

Kim KN, Kang JH, Yim SV, Park CS

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):143-148.
  • doi: 10.4196/kjpp.2008.12.4.143
Caveolin-1 (CAV1) is an integral membrane protein that may function as a scaffold for plasma membrane proteins and acts as a tumor suppressor protein. One causative factor of chemotherapy- resistant...
Relaxation Effect of Synthetic Ceramide Analogues in Cat Esophageal Smooth Muscle Cells

Lee DW, Park SY, Ryu JS, Kim SH, Im CU, Choi SH, Lee SE, Ko SK, Sohn UD

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):137-142.
  • doi: 10.4196/kjpp.2008.12.4.137
Ceramide has emerged as a novel second messenger for intracellular signalling. It is produced from sphingomyelin and is involved in the control of cell differntiation, proliferation, and apoptosis. C2- ceramide,...
Characterization of Ionic Currents in Human Neural Stem Cells

Lim CG, Kim SS, Suh-Kim H, Lee YD, Ahn SC

  • Korean J Physiol Pharmacol.
  • 2008 Aug;12(4):131-135.
  • doi: 10.4196/kjpp.2008.12.4.131
The profile of membrane currents was investigated in differentiated neuronal cells derived from human neural stem cells (hNSCs) that were obtained from aborted fetal cortex. Whole-cell voltage clamp recording revealed...

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