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8 results

Assessment of Relationship between Fyn-related Kinase Gene Polymorphisms and Overweight/Obesity in Korean Population

Jung MY, Kim BS, Kim YJ, Koh IS, Chung JH

  • Korean J Physiol Pharmacol.
  • 2008 Apr;12(2):83-87.
  • doi: 10.4196/kjpp.2008.12.2.83
The fyn-related kinase (FRK) belongs to the tyrosine kinase family of protein kinases. Recent studies have shown that Frk affects pancreatic beta cell number during embryogenesis and promotes beta cell...
Protective Effect of Decursinol on Mouse Models of Sepsis: Enhancement of Interleukin-10

Jung JS, Yan JJ, Song DK

  • Korean J Physiol Pharmacol.
  • 2008 Apr;12(2):79-81.
  • doi: 10.4196/kjpp.2008.12.2.79
The effects of decursinol on various models of sepsis were investigated. Intra-peritoneal pretreatment of mice with various doses of decursinol (1~100 mg/kg) effectively suppressed lethality induced in three mouse models...
Testosterone Relaxes Rabbit Seminal Vesicle by Calcium Channel Inhibition

Kim JK, Han WH, Lee MY, Myung SC, Kim SC, Kim MK

  • Korean J Physiol Pharmacol.
  • 2008 Apr;12(2):73-77.
  • doi: 10.4196/kjpp.2008.12.2.73
Recent studies have documented that testosterone relaxes several smooth muscles by modulating K+channel activities. Smooth muscles of seminal vesicles play a fundamental role in ejaculation, which might involve testosterone. This...
Glycyrrhizin Attenuates MPTP Neurotoxicity in Mouse and MPP+-Induced Cell Death in PC12 Cells

Kim YJ, Lee CS

  • Korean J Physiol Pharmacol.
  • 2008 Apr;12(2):65-71.
  • doi: 10.4196/kjpp.2008.12.2.65
The present study examined the inhibitory effect of licorice compounds glycyrrhizin and a metabolite 18 beta-lycyrrhetinic acid on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse and on the 1-methyl-4-phenylpyridinium...
Relaxant Effect of Spermidine on Acethylcholine and High K+-induced Gastric Contractions of Guinea-Pig

Kim YC, Sim JH, Choi W, Kim CH, You RY, Xu WX, Lee SJ

  • Korean J Physiol Pharmacol.
  • 2008 Apr;12(2):59-64.
  • doi: 10.4196/kjpp.2008.12.2.59
In our previous study, we found that spermine and putrescine inhibited spontaneous and acetylcholine (ACh)-induced contractions of guinea-pig stomach via inhibition of L-type voltage- dependent calcium current (VDCCL). In this...
Expression of Ca2+ -activated K+ Channels and Their Role in Proliferation of Rat Cardiac Fibroblasts

Choi S, Lee W, Yun J, Seo J, Lim I

  • Korean J Physiol Pharmacol.
  • 2008 Apr;12(2):51-58.
  • doi: 10.4196/kjpp.2008.12.2.51
Cardiac fibroblasts constitute one of the largest cell populations in the heart, and contribute to structural, biochemical, mechanical and electrical properties of the myocardium. Nonetheless, their cardiac functions, especially electrophysiological...
Effects of Apigenin on Glutamate-induced [Ca2+]i Increases in Cultured Rat Hippocampal Neurons

Han JH, Kim KJ, Jang HJ, Jang JH, Kim MJ, Sung KW, Rhie DJ, Jo YH, Hahn SJ, Lee MY, Yoon SH

  • Korean J Physiol Pharmacol.
  • 2008 Apr;12(2):43-49.
  • doi: 10.4196/kjpp.2008.12.2.43
Flavonoids have been shown to affect calcium signaling in neurons. However, there are no reports on the effect of apigenin on glutamate-induced calcium signaling in neurons. We investigated whether apigenin...
Melatonin Induces Akt Phosphorylation through Melatonin Receptor- and PI3K-Dependent Pathways in Primary Astrocytes

Kong PJ, Byun JS, Lim SY, Lee JJ, Hong SJ, Kwon KJ, Kim SS

  • Korean J Physiol Pharmacol.
  • 2008 Apr;12(2):37-41.
  • doi: 10.4196/kjpp.2008.12.2.37
Melatonin has been reported to protect neurons from a variety of neurotoxicity. However, the underlying mechanism by which melatonin exerts its neuroprotective property has not yet been clearly understood. We...

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