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10 results

Inhibition of the Desensitization of Canonical Transient Receptor Potential Channel 5 by Dimethyl Sulfoxide

Kim BJ, So I

  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):227-231.
The classic type of transient receptor potential channel (TRPC) is a molecular candidate for Ca2+-permeable cation channel in mammalian cells. TRPC5 is rapidly desensitized after activation by G protein-coupled receptor....
Multiple 5-Hydroxytryptamine (5-HT) Receptors Are Involved in the Melittin-induced Nociceptive Responses in Rat I. Role of Peripheral 5-HT Receptor

Shin HK, Lee SE

  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):221-226.
Melittin-induced tonic pain model is characterized by local inflammation, edema, spontaneous flinchings, and sustained mechanical hypersensitivity. These nociceptive responses are mediated through selective activation of capsaicin-sensitive primary afferent fibers by...
Mechanical Hyperalgesia Induced by Blocking Calcium-activated Potassium Channels on Capsaicin-sensitive Afferent Fiber

Lee KH, Shin HK

  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):215-219.
Small and large conductance Ca2+-activated K+ (SKCa and BKCa) channels are implicated in the modulation of neuronal excitability. We investigated how changes in peripheral KCa channel activity affect mechanical sensitivity...
Regulation of Ba2+-Induced Contraction of Murine Ureteral Smooth Muscle

Kim YC, Lee MY, Kim WJ, Myung SC, Choi W, Kim CH, Xu WX, Kim SR, Lee SJ

  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):207-213.
This study was designed to characterize ureteral smooth muscle motility and also to study the effect of forskolin (FSK) and isoproterenol (ISO) on smooth muscle contractility in murine ureter. High...
Influence of SKF81297 on Catecholamine Release from the Perfused Rat Adrenal Medulla

Choi DH, Cha JH, Lim DY

  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):197-206.
The aim of the present study was to investigate the effects of 6-chloro-7,8-dihydroxy-1-phenyl-2,3, 4,5-tetrahydro-1H-3-benzazepine (SKF81297), a selective agonist of dopaminergic D1 receptor, on the secretion of catecholamines (CA) evoked by...
Effects of Antioxidants on the Gamma-Radiation Damage of the Cultured Vascular Smooth Mucle Cells of Rat Aorta

Lee JD, Choi HC, Kang YJ, Kim MS, Lee KY

  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):189-195.
To study the protective effects of antioxidants on the radiation damages of the cells, vascular smooth muscle cells (VSMC) from thoracic aorta of Sprague-Dawley rats were cultured and irradiated with...
Ca2+-dependent Long-term Inactivation of Cardiac Na+/Ca2+ Exchanger

Lee JE, Kang TM

  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):183-188.
Using BHK cells with stable expression of cardiac Na+/Ca2+ exchanger (BHK-NCX1), reverse mode (i.e. Ca2+ influx mode) of NCX1 current was recorded by whole-cell patch clamp. Repeated stimulation of reverse...
Prostaglandin E1 Increases cGMP Levels in Beating Rabbit Atria: Lack of Effects of PGE1-induced Cyclic Nucleotides on Secretory and Contractile Functions

Jin XS, Quan HX, Kim SY, Park SH, Kim SZ, Lee HS, Cho KW

  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):175-182.
Members of prostaglandin (PG) E-series elicit cellular effects mainly through adenylyl cyclase-cAMP signaling. The role of PGE2-induced increase in cAMP has been shown to be compartmentalized in the cardiac myocytes:...
Neuroprotective Effects of Methanol Extracts of Jeju Native Plants on Hydrogen Peroxide-induced Cytotoxicity in SH-SY5Y Human Neuroblastoma Cells

Kong PJ, Kim YM, Lee HJ, Kim SS, Yoo ES, Chun W

  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):171-174.
Neuronal death is a common characteristic hallmark of a variety of neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. However, there have been no effective drugs to successfully prevent neuronal...
Protein Kinase C-mediated Neuroprotective Action of (-)-epigallocatechin-3-gallate against Abeta1-42-induced Apoptotic Cell Death in SH-SY5Y Neuroblastoma Cells

Jang S, You KW, Kim SH, Park SJ, Jeong HS, Park JS

  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):163-169.
The neurotoxicity of amyloid beta (Abeta) is associated with an increased production of reactive oxygen species and apoptosis, and it has been implicated in the development of Alzheimer's disease. While...

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