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9 results

Promoting Effect of Hydrogen Peroxide on 1-Methyl-4-phenylpyridinium-induced Mitochondrial Dysfunction and Cell Death in PC12 Cells

Lee DH, Lee CS

  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):51-58.
The promoting effect of hydrogen peroxide (H2O2) against the cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) in differentiated PC12 cells was assessed by measuring the effect on the mitochondrial membrane permeability. Treatment of...
Melittin-induced Nociceptive Responses are Alleviated by Cyclooxygenase-1 Inhibitor

Kim J, Shin HK, Lee KH

  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):45-50.
Melittin-induced pain model has been known to be very useful for the study of pain mechanism. Melittin-induced nociceptive responses are reported to be modulated by the changes in the activity...
Short-Term High Expression of Interferon-Alpha Modulates Progression of Type 1 Diabetes in NOD Mice

Park MK, Seo SY, Hong SH, Kim HJ, Park EJ, Kim DK, Lee HJ

  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):39-44.
Type I diabetes (T1D) is an organ-specific autoimmune disease caused by the T cell-mediated destruction of the insulin-producing beta cells in the pancreatic islets. The onset of T1D is the...
Fluoxetine Modulates Corticostriatal Synaptic Transmission through Postsynaptic Mechanism

Cho HS, Choi SJ, Kim KJ, Lee HH, Cho YJ, Kim SY, Sung KW

  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):31-38.
Fluoxetine, widely used for the treatment of depression, is known to be a selective serotonin reuptake inhibitor (SSRI), however, there are also reports that fluoxetine has direct effects on several...
Lysophosphatidylcholine Attenuates Endothelium-dependent Relaxation Responses through Inhibition of ACh-induced Endothelial [Ca2+]i Increase

Kwon SC, Lee YH, Nam T, Ahn DS

  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):25-30.
Lysophosphatidylcholine (LPC), which accumulates in atherosclerotic arteries, has been reported to inhibit endothelium-dependent relaxation (EDR) in many different species. However, the underlying mechanism of LPC-induced inhibition of EDR is still...
Differential Functional Expression of Clotrimazole-sensitive Ca2+-activated K+ Current in Bal-17 and WEHI-231 Murine B Lymphocytes

Zheng H, Ko JH, Nam JH, Earm YE, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):19-24.
The intermediate conductance Ca2+-activated K+ channels (SK4, IKCa1) are present in lymphocytes, and their membrane expression is upregulated by various immunological stimuli. In this study, the activity of SK4 was...
Changes of CA1 Excitability in Rats after Prenatal Methylazoxymethanol Treatment

Jang SY, Choi IS, Cho JH, Jang IS, Lee MG, Choi BJ

  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):13-17.
Experimentally induced cortical disorganization exhibits many anatomical features which are characteristic of cortical malformations in children with early-onset epilepsy. We used an immunocytochemical technique and extracellular field potential recordings from...
pH-mediated Regulation of Pacemaker Activity in Cultured Interstitial Cells of Cajal

Kim BJ, Lee JH, So I, Kim KW

  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):7-11.
Interstitial cells of Cajal (ICCs) are pacemakers in gastrointestinal tracts, regulating rhythmicity by activating nonselective cation channels (NSCCs). In the present study, we investigated the general characteristics and pH-mediated regulation...
Metformin Enhances Leptin Sensitivity in Aged Rats

Kim SR, Park SY, Kim JY, Kim YW

  • Korean J Physiol Pharmacol.
  • 2006 Feb;10(1):1-6.
To evaluate whether metformin restores leptin sensitivity in aged rats with leptin resistance, we measured leptin sensitivity in aged (2 year old) and adult (5 month old) rats after 4...

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