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9 results

Development of Luciferase Reporter Gene-based Cell Bioassay for the Aromatic Hydrocarbon Receptor Agonists

Kim SY, Choi EJ, Yang JH

  • Korean J Physiol Pharmacol.
  • 2006 Dec;10(6):349-354.
The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals. The application of recombinant...
Upregulation of Renin-angiotensin, Endothelin and C-type Natriuretic Peptide in Rat Glomerulus with Bilateral Ureteral Obstruction

Bae EH, Kim SW

  • Korean J Physiol Pharmacol.
  • 2006 Dec;10(6):343-347.
The present study was designed to investigate the effects renin-angiotensin-aldosterone system (RAAS), endothelin (ET) and local natriuretic peptide (NP) system for glomerulopathy induced in the experimental bilateral ureteral obstructive rats....
Alteration of Nitric Oxide Synthase and Guanylyl Cyclase Activity in Rats with Ischemia/Reperfusion Renal Injury

Bae EH, Kim SW

  • Korean J Physiol Pharmacol.
  • 2006 Dec;10(6):337-341.
The present study was designed to investigate the protein expression of nitric oxide synthase (NOS) and guanylyl cyclase (GC) activity in ischemia/perfusion (I/R) renal injury in rats. Renal I/R injury...
Involvement of Caspases and Bcl-2 Family in Nitric Oxide-Induced Apoptosis of Rat PC12 Cells

Jeong YJ, Jung JY, Lee JH, Cho JH, Lee GS, Kim SH, Kim WJ

  • Korean J Physiol Pharmacol.
  • 2006 Dec;10(6):329-335.
This study was aimed to investigate the nitric oxide (NO)-induced cytotoxic mechanism in PC12 cells. Sodium nitroprusside (SNP), an NO donor, decreased the viability of PC12 cells in dose- and...
Alpha-Calcitonin Gene-Related Peptide-Null Mice Shows Normal Responses to Various Noxious Stimuli

Lee J, Emeson RB

  • Korean J Physiol Pharmacol.
  • 2006 Dec;10(6):323-327.
Despite the wealth of data concerning the roles of alpha-CGRP in nociceptive behaviors, alpha-CGRP-null mice showed no obvious phenotypic differences in nociceptive behaviors from wild type. The present studies specifically...
Glycyrrhizin and Morroniside Stimulate Mucin Secretion from Cultured Airway Epithelial Cells

Heo HJ, Lee HJ, Kim C, Son KH, Kim YC, Kim YS, Kang SS, Park YC, Kim YH, Seo UK, Seok JH, Lee CJ

  • Korean J Physiol Pharmacol.
  • 2006 Dec;10(6):317-321.
In this study, we investigated whether glycyrrhizin, prunetin and morroniside affect mucin secretion from cultured airway epithelial cells and compared the possible activities of these agents with the inhibitory action...
Baicalein Protects 6-OHDA-induced Neuronal Damage by Suppressing Oxidative Stress

Im HI, Nam E, Lee ES, Hwang YJ, Kim YS

  • Korean J Physiol Pharmacol.
  • 2006 Dec;10(6):309-315.
The protective effects of baicalein, one of the flavonoids in Scutellaria baicalensis Georgi, were evaluated against 6-hydroxydopamine (6-OHDA)-induced neuronal damage in mice and cultured human neuroblastoma cells. Nigrostriatal damage was...
NMDA Receptor-dependent Inhibition of Synaptic Transmission by Acute Ethanol Treatment in Rat Corticostriatal Slices

Choi SJ, Kim KJ, Cho HS, Kim SY, Yim DS, Cho YJ, Hahn SJ, Sung KW

  • Korean J Physiol Pharmacol.
  • 2006 Dec;10(6):303-307.
The effects of ethanol on corticostriatal synaptic transmission were examined, using extracellular recording and analysis of population spike amplitudes in rat brain slices, to study how acute ethanol intoxication impairs...
Calcium Ions are Involved in Modulation of Melittin-induced Nociception in Rat: II. Effect of Calcium Chelator

Shin HK, Lee KH, Cho CH

  • Korean J Physiol Pharmacol.
  • 2006 Dec;10(6):297-302.
Melittin, a major component of bee venom, produces a sustained decrease in mechanical threshold, and an increase in spontaneous flinchings and paw thickness, which are characteristics similar to those induced...

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