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8 results

Characterization of ETB Receptor-mediated Relaxation in Precontracted Mesenteric Artery from Streptozotocin-induced Diabetic Rats

Eom YK, Kim KH, Rhim BY

  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):305-314.
Diabetes mellitus is associated with vascular complications, including an impairment of vascular function and alterations in the reactivity of blood vessels to vasoactive substances in various vasculature. In the present...
Differential Activation of Ras/Raf/MAPK Pathway between Heart and Cerebral Artery in Isoproterenol-induced Cardiac Hypertrophy

Kim H, Kim N, Joo H, Youm JB, Park WS, Warda M, Kang S, Thu VT, Khoa TM, Han J

  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):299-304.
Cardiac hypertrophy contributes an increased risk to major cerebrovascular events. However, the molecular mechanisms underlying cerebrovascular dysfunction during cardiac hypertrophy have not yet been characterized. In the present study, we...
Changes of Cytosolic Ca2+ under Metabolic Inhibition in Isolated Rat Ventricular Myocytes

Kang S, Kim N, Joo H, Youm JB, Park WS, Warda M, Kim H, Cuong DV, Kim T, Kim E, Han J

  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):291-298.
To characterize cytosolic Ca2+ fluctuations under metabolic inhibition, rat ventricular myocytes were exposed to 200microM 2, 4-dinitrophenol (DNP), and mitochondrial Ca2+, mitochondrial membrane potential (delta psi m), and cytosolic Ca2+...
YS 49, a Synthetic Isoquinoline Alkaloid, Protects Sheep Pulmonary Artery Endothelial Cells from tert-butylhydroperoxide-mediated Cytotoxicity

Chong WS, Kang SY, Kang YJ, Park MK, Lee YS, Kim HJ, Seo HG, Lee JH, Yun-Choi H, Chang KC

  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):283-289.
Endothelium, particularly pulmonary endothelium, is predisposed to injury by reactive oxygen species (ROS) and their derivatives. Heme oxygenase (HO) has been demonstrated to provide cytoprotective effects in models of oxidant-induced...
Regulation of Vacuolar H+-ATPase c Gene Expression by Oxidative Stress

Kwak WJ, Kim SM, Kim MS, Kang JH, Kim DJ, Kim HS, Kown OJ, Kim IK, Jeong SW

  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):275-282.
By using differential display, we identified one of the genes encoding the multi-subunit complex protein V-ATPase, c subunit gene (ATP6L), and showed alterations of the gene expression by oxidative stresses....
Two Types of Voltage-activated Calcium Currents in Goldfish Horizontal Cells

Paik SS, Bai SH, Jung CS

  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):269-273.
In horizontal cells (HCs) that were freshly dissociated from goldfish retina, two types of voltage- dependent calcium currents (ICa) were recorded using a patch-clamping configuration: a transient type current and...
Dopamine Modulates Corticostriatal Synaptic Transmission through Both D1 and D2 Receptor Subtypes in Rat Brain

Lee HH, Choi SJ, Kim KJ, Cho HS, Kim SY, Sung KW

  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):263-268.
Striatum has important roles in motor control, habitual learning and memory. It receives glutamatergic inputs from neocortex and thalamus, and dopaminergic inputs from substantia nigra. We examined effects of dopamine...
5-Hydroxytryptamine Inhibits Glutamatergic Synaptic Transmission in Rat Corticostriatal Brain Slice

Cho HS, Choi SJ, Kim KJ, Lee HH, Kim SY, Cho YJ, Sung KW

  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):255-262.
Striatum is involved in the control of movement and habitual memory. It receives glutamatergic input from wide area of the cerebral cortex as well as an extensive serotonergic (5-hydroxytryptamine, 5-HT)...

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