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YS 49, a Synthetic Isoquinoline Alkaloid, Protects Sheep Pulmonary Artery Endothelial Cells from tert-butylhydroperoxide-mediated Cytotoxicity

Chong WS, Kang SY, Kang YJ, Park MK, Lee YS, Kim HJ, Seo HG, Lee JH, Yun-Choi H, Chang KC

  • KMID: 1600111
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):283-289.
Endothelium, particularly pulmonary endothelium, is predisposed to injury by reactive oxygen species (ROS) and their derivatives. Heme oxygenase (HO) has been demonstrated to provide cytoprotective effects in models of oxidant-induced...
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Differential Activation of Ras/Raf/MAPK Pathway between Heart and Cerebral Artery in Isoproterenol-induced Cardiac Hypertrophy

Kim H, Kim N, Joo H, Youm JB, Park WS, Warda M, Kang S, Thu VT, Khoa TM, Han J

  • KMID: 1600113
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):299-304.
Cardiac hypertrophy contributes an increased risk to major cerebrovascular events. However, the molecular mechanisms underlying cerebrovascular dysfunction during cardiac hypertrophy have not yet been characterized. In the present study, we...
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Dopamine Modulates Corticostriatal Synaptic Transmission through Both D1 and D2 Receptor Subtypes in Rat Brain

Lee HH, Choi SJ, Kim KJ, Cho HS, Kim SY, Sung KW

  • KMID: 1600108
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):263-268.
Striatum has important roles in motor control, habitual learning and memory. It receives glutamatergic inputs from neocortex and thalamus, and dopaminergic inputs from substantia nigra. We examined effects of dopamine...
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5-Hydroxytryptamine Inhibits Glutamatergic Synaptic Transmission in Rat Corticostriatal Brain Slice

Cho HS, Choi SJ, Kim KJ, Lee HH, Kim SY, Cho YJ, Sung KW

  • KMID: 1600107
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):255-262.
Striatum is involved in the control of movement and habitual memory. It receives glutamatergic input from wide area of the cerebral cortex as well as an extensive serotonergic (5-hydroxytryptamine, 5-HT)...
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Two Types of Voltage-activated Calcium Currents in Goldfish Horizontal Cells

Paik SS, Bai SH, Jung CS

  • KMID: 1600109
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):269-273.
In horizontal cells (HCs) that were freshly dissociated from goldfish retina, two types of voltage- dependent calcium currents (ICa) were recorded using a patch-clamping configuration: a transient type current and...
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Changes of Cytosolic Ca2+ under Metabolic Inhibition in Isolated Rat Ventricular Myocytes

Kang S, Kim N, Joo H, Youm JB, Park WS, Warda M, Kim H, Cuong DV, Kim T, Kim E, Han J

  • KMID: 1600112
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):291-298.
To characterize cytosolic Ca2+ fluctuations under metabolic inhibition, rat ventricular myocytes were exposed to 200microM 2, 4-dinitrophenol (DNP), and mitochondrial Ca2+, mitochondrial membrane potential (delta psi m), and cytosolic Ca2+...
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Characterization of ETB Receptor-mediated Relaxation in Precontracted Mesenteric Artery from Streptozotocin-induced Diabetic Rats

Eom YK, Kim KH, Rhim BY

  • KMID: 1600114
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):305-314.
Diabetes mellitus is associated with vascular complications, including an impairment of vascular function and alterations in the reactivity of blood vessels to vasoactive substances in various vasculature. In the present...
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Regulation of Vacuolar H+-ATPase c Gene Expression by Oxidative Stress

Kwak WJ, Kim SM, Kim MS, Kang JH, Kim DJ, Kim HS, Kown OJ, Kim IK, Jeong SW

  • KMID: 1600110
  • Korean J Physiol Pharmacol.
  • 2005 Oct;9(5):275-282.
By using differential display, we identified one of the genes encoding the multi-subunit complex protein V-ATPase, c subunit gene (ATP6L), and showed alterations of the gene expression by oxidative stresses....
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