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TASK-1 Channel Promotes Hydrogen Peroxide Induced Apoptosis

Yun J, Kim S, Bang H

  • Korean J Physiol Pharmacol.
  • 2005 Feb;9(1):63-68.
Hydrogen peroxide (H2O2) causes oxidative stress and is considered as an inducer of cell death in various tissues. Two-pore domain K+ (K2p) channels may mediate K+ efflux during apoptotic volume...
Effect of Extracts from Safflower Seeds on Osteoblastic Differentiation and Intracellular Free Calcium Concentration in MC3T3-E1 Cells

Jang HO, Eom HS, Roh SB, Yun I

  • Korean J Physiol Pharmacol.
  • 2005 Feb;9(1):55-62.
Very little research has been carried out on safflower seed for the prevention and treatment of the bone deficiency diseases, including osteoporosis, which are supported by scientific evidences. In the...
D-Amphetamine Causes Dual Actions on Catecholamine Release from the Rat Adrenal Medulla

Lim GH, Na GM, Min SY, Seo YS, Park CW, Lim DY

  • Korean J Physiol Pharmacol.
  • 2005 Feb;9(1):45-53.
The present study was designed to examine the effect of d-amphetamine on CA release from the isolated perfused model of the rat adrenal gland, and to establish its mechanism of...
Acetylcholine Induces Hyperpolarization Mediated by Activation of K (Ca) Channels in Cultured Chick Myoblasts

Lee D, Han J, Park JY

  • Korean J Physiol Pharmacol.
  • 2005 Feb;9(1):37-43.
Our previous report demonstrated that chick myoblasts are equipped with Ca2+-permeable stretch- activated channels and Ca2+-activated potassium channels (KCa), and that hyperpolarization-induced by KCa channels provides driving force for Ca2+...
Buffering Contribution of Mitochondria to the [Ca2+]i Increase by Ca2+ Influx through Background Nonselective Cation Channels in Rabbit Aortic Endothelial Cells

Kim YC, Lee SJ, Kim KW

  • Korean J Physiol Pharmacol.
  • 2005 Feb;9(1):29-35.
To prove the buffering contribution of mitochondria to the increase of intracellular Ca2+ level ([Ca2+]i) via background nonselective cation channel (background NSCC), we examined whether inhibition of mitochondria by protonophore...
Intra-articular Injection of IL-1beta Facilitated Formalin-induced Temporomandibular Joint Pain in Freely Moving Rats

Choi HS, Jung SC, Choi BJ, Ahn DK

  • Korean J Physiol Pharmacol.
  • 2005 Feb;9(1):23-27.
The present study was performed to investigate the effects of intra-articular injection of interleukin-1beta (IL-1beta) on the formalin-induced temporomandibular joint (TMJ) pain. Under anesthesia, a 30-gauge needle was introduced into...
Differential Effects of Typical and Atypical Antipsychotics on MK- 801-induced EEG Changes in Rats

Kwon JS, Kim KM, Chang SM, Kim CY, Chung TH, Choi BJ, Lee MG

  • Korean J Physiol Pharmacol.
  • 2005 Feb;9(1):17-22.
We examined whether the abnormal EEG state by NMDA receptor blocker MK-801 can be reversed by typical and atypical antipsychotics differentially by comparing their spectral profiles after drug treatment in...
Effects of PCB Congeners in Rodent Neuronal Cells in Culture

Kim SY, Yang JH

  • Korean J Physiol Pharmacol.
  • 2005 Feb;9(1):9-15.
We attempted to analyze the mechanism of polychlorinated biphenyl (PCB) -induced neurotoxicity and identify the target molecules in the neuronal cells for PCBs. Since the developing neuron is particularly sensitive...
Mechanisms of Myotonic Dystrophies 1 and 2

Lubov T

  • Korean J Physiol Pharmacol.
  • 2005 Feb;9(1):1-8.
Myotonic Dystrophies type 1 and 2 (DM1/2) are neuromuscular disorders which belong to a group of genetic diseases caused by unstable CTG triplet repeat (DM1) and CCTG tetranucleotide repeat (DM2)...

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