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Differential Inhibition of MPP+- or 6-Hydroxydopamine-induced Cell Viability Loss in PC12 Cells by Trifluoperazine and W-7

Lee CS

  • KMID: 1600082
  • Korean J Physiol Pharmacol.
  • 2005 Aug;9(4):247-253.
The present study assessed the effect of calmodulin antagonists trifluoperazine and W-7 against the cytotoxicity of MPP+ and 6-hydroxydopamine (6-OHDA) in relation to the mitochondrial dysfunction and cell death in...
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Inhibition of Nitric Oxide-induced Neuronal Apoptosis in PC12 Cells by Epigallocatechin Gallate

Jung JY, Jeong YJ, Han CR, Kim SH, Kim HJ, Lee KH, Park HO, Kim WJ

  • KMID: 1600081
  • Korean J Physiol Pharmacol.
  • 2005 Aug;9(4):239-246.
In the central nervous system, nitric oxide (NO) is associated with many pathological diseases such as brain ischemia, neurodegeneration and inflammation. The epigallocatechin gallate (EGCG), a major compound of green...
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Inhibition of Hypoxia-induced Apoptosis in PC12 Cells by Estradiol

Jung JY, Roh KH, Jeong YJ, Kim SH, Lee EJ, Kim MS, Oh WM, Oh HK, Kim WJ

  • KMID: 1600079
  • Korean J Physiol Pharmacol.
  • 2005 Aug;9(4):231-238.
Neuronal apoptotic events, which result in cell death, are occurred in hypoxic/ischemic conditions. Estradiol is a female sex hormone with steroid structure known to provide neuroprotection through multiple mechanisms in...
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Naltrexone Inhibits Catecholamine Secretion Evoked by Nicotinic Receptor Stimulation in the Perfused Rat Adrenal Medulla

Yu BS, Min SY, Seo YS, Choi CH, Lee EH, Lim DY

  • KMID: 1600077
  • Korean J Physiol Pharmacol.
  • 2005 Aug;9(4):223-230.
The purpose of the present study was to examine the effect of naltrexone, an opioid antagonist, on secretion of catecholamines (CA) evoked by cholinergic nicotinic stimulation and membrane-depolarization from the...
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Androgen Hormone Inhibits Expression of iNOS and COX-2 Protein in Rat Vascular Smooth Muscle Cell

Bae HY, Park JE, Jeon EM, Kang YJ, Lee KY, Choi HC

  • KMID: 1600075
  • Korean J Physiol Pharmacol.
  • 2005 Aug;9(4):215-221.
We investigated the effects of testosterone and dihydrotestosterone on inflammatory response of iNOS and COX-2 expression in rat vascular smooth muscle cells. Rat vascular smooth muscle cells (VSMC) stimulated with...
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The Role of Mitochondrial ATP-sensitive Potassium Channel on Intestinal Pacemaking Activity

Kim BJ, Kim KW

  • KMID: 1600073
  • Korean J Physiol Pharmacol.
  • 2005 Aug;9(4):209-213.
Interstitial cells of Cajal (ICCs) are the pacemaker cells that generate slow waves in the gastrointestinal (GI) tract. In the present study, we investigated the effect of mitochondrial ATP-sensitive potassium...
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The Effect of External Divalent Cations on Intestinal Pacemaking Activity

Kim BJ, Kim KW

  • KMID: 1600071
  • Korean J Physiol Pharmacol.
  • 2005 Aug;9(4):203-207.
Electrical rhythmicity in the gastrointestinal (GI) muscles is generated by pacemaker cells, known as interstitial cells of Cajal (ICC). In the present study, we investigated the effect of external divalent...
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Inhibition of Sarcoplasmic Reticulum Ca2+ Uptake by Pyruvate and Fatty Acid in H9c2 Cardiomyocytes: Implications for Diabetic Cardiomyopathy

Lee EH, Lee HK, Kim HW, Kim YH

  • KMID: 1600069
  • Korean J Physiol Pharmacol.
  • 2005 Aug;9(4):195-201.
High extracellular glucose concentration was reported to suppress intracellular Ca2+ clearing through altered sarcoplasmic reticulum (SR) function. In the present study, we attempted to elucidate the effects of pyruvate and...
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Protein Kinase C Activates ATP-sensitive Potassium Channels in Rabbit Ventricular Myocytes

Kim N, Youm JB, Joo H, Kim H, Kim E, Han J

  • KMID: 1600067
  • Korean J Physiol Pharmacol.
  • 2005 Aug;9(4):187-193.
Several signal transduction pathways have been implicated in ischemic preconditioning induced by the activation of ATP-sensitive K+ (KATP) channels. We examined whether protein kinase C (PKC) modulated the activity of...
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