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9 results

Modulation of Large Conductance Ca2+-activated K+ Channel of Skin Fibroblast (CRL-1474) by Cyclic Nucleotides

Yun J, Kim S, Bang H

  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):131-135.
Potassium channels in human skin fibroblast have been studied as a possible site of Alzheimer disease pathogenesis. Fibroblasts in Alzheimer disease show alterations in signal transduction pathway such as changes...
Insulin Resistance of Skeletal Muscle was Recovered by Leptin Injection in vivo, but not in vitro, in High-fat Diet Fed Rats

Doh KO, Park JO, Jeon JR, Kim JY

  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):125-130.
We examined the effect of leptin on the insulin resistance in skeletal muscles by measuring the glucose transport. Male Wistar rats were fed with chow or high-fat diets for 30...
Inhibition of Angiotensin II-Induced Vascular Smooth Muscle Cell Hypertrophy by Different Catechins

Zheng Y, Song HJ, Yun SH, Chae YJ, Jia H, Kim CH, Ha TS, Sachinidis A, Ahn HY, Davidge ST

  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):117-123.
A cumulative evidence indicates that consumption of tea catechin, flavan-3-ol derived from green tea leaves, lowers the risk of cardiovascular diseases. However, a precise mechanism for this cardiovascular action has...
Enhanced Expression of Cell Adhesion Molecules in the Aorta of Diabetic Mice is Mediated by gp91phox-derived Superoxide

Yun MR, Kim JJ, Lee SM, Heo HJ, Bae SS, Kim CD

  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):109-115.
Endothelial activation and subsequent recruitment of inflammatory cells are important steps in atherogenesis. The increased levels of cell adhesion molecules (CAM) have been identified in diabetic vasculatures, but the underlying...
Regulation of L-type Calcium Channel Current by Somatostatin in Guinea-Pig Gastric Myocytes

Kim YC, Sim JH, Lee SJ, Kang TM, Kim SJ, Kim SR, Youn SJ, Lee SJ, Xu WX, So I, Kim KW

  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):103-108.
To study the direct effect of somatostatin (SS) on calcium channel current (IBa) in guinea-pig gastric myocytes, IBa was recorded by using whole-cell patch clamp technique in single smooth muscle...
Na+-Ca2+ Exchange Curtails Ca2+ before Its Diffusion to Global Ca2+i in the Rat Ventricular Myocyte

Ahn SW, Ko CM

  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):95-101.
In the heart, Na+-Ca2+ exchange (NCX) is the major Ca2+ extrusion mechanism. NCX has been considered as a relaxation mechanism, as it reduces global [Ca2+]i raised during activation. However, if...
Ca2+-induced Ca2+ Release from Sarcoplasmic Reticulum Negatively Regulates Myocytic ANP Release in Beating Rabbit Atria

Li D, Quan HX, Wen JF, Jin JY, Park SH, Kim SY, Kim SZ, Cho KW

  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):87-94.
It is not clear whether Ca2+-induced Ca2+ release from the sarcoplasmic reticulum (SR) is involved in the regulation of atrial natriuretic peptide (ANP) release. Previously, we have shown that nifedipine...
Morphine-induced Modulation of Nociceptive Spinal Dorsal Horn Neuronal Activities after Formalin-induced Inflammatory Pain

Park JM, Li KW, Jung SJ, Kim J, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):77-86.
In this study, we examined the morphine-induced modulation of the nociceptive spinal dorsal horn neuronal activities before and after formalin-induced inflammatory pain. Intradermal injection of formalin induced time-dependent changes in...
Higher Expression of TRPM7 Channels in Murine Mature B Lymphocytes than Immature Cells

Kim JK, Ko JH, Nam JH, Woo JE, Min KM, Earm YE, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):69-75.
TRPM7, a cation channel protein permeable to various metal ions such as Mg2+, is ubiquitously expressed in variety of cells including lymphocytes. The activity of TRPM7 is tightly regulated by...

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