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10 results

Pharmacokinetics of Dehydroevodiamine Following Intravenous Administration in Rats

Kim SY, Moon CS, Choi YS, Lee SB

  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):65-67.
Dehydroevodiamine (DHED) is one of the bioactive components of the Chinese herbal medicine Wu-chu-yu-tang that has been shown to produce various pharmacological effects. In the present study, we investigated the...
Efffects of Fluoxetine on ATP-induced Calcium Signaling in PC12 Cells

Lee YM, Kim HJ, Hong SH, Kim MJ, Min DS, Rhie DJ, Kim MS, Jo YH, Hahn SJ, Yoon SH

  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):57-63.
Fluoxetine, a widely used anti-depressant compound, has several additional effects, including blockade of voltage-gated ion channels. We examined whether fluoxetine affects ATP-induced calcium signaling in PC12 cells by using fura-2-based...
Anti-Apoptotic Effect of Rheum undulatum Water Extract in Pancreatic beta-cell Line, HIT-T15

Yoon SH, Hong MS, Chung JH, Chung SH

  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):51-55.
Sopungsungi-won has been used as a traditional medicine for diabetes and it has been proved to be a potential remedy for type 2 diabetes mellitus. We previously reported that water...
Effect of Amrinone, a Selective Inhibitor of Phosphodiesterase III, on PMNs-induced Cardiac Dysfunction in Ischemia/reperfusion

Oh BK, Kim HK, Choi SR, Song JH, Park ES, Choi BS, Park JD, Shin YK

  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):43-50.
Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in a marked cardiac contractile dysfunction. Amrinone, a specific inhibitor of phosphodiesterase 3, has an antioxidant activity against...
Role of Stretch-Activated Channels in Stretch-Induced Changes of Electrical Activity in Rat Atrial Myocytes

Youm JB, Jo SH, Leem CH, Ho WK, Earm YE

  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):33-41.
We developed a cardiac cell model to explain the phenomenon of mechano-electric feedback (MEF), based on the experimental data with rat atrial myocytes. It incorporated the activity of ion channels,...
Role of STAT3-Interacting Protein (STIP1) in delta12-Prostaglandin J2-Induced Cell Death

Kim SM, Lee S, Kwak HJ, Kim BE, Kim DJ, Kim IK, Jeong SW

  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):27-31.
delta12-Prostaglandin J2 (delta12-PGJ2) is one of cyclopentenone prostaglandins. The delta12-PGJ2 is known to induce apoptosis of tumor cells, however, it's action mechanism is not clear. It has recently been reported...
Economical Sweating Function in Africans: Quantitative Sudomotor Axon Reflex Test

Lee JB, Bae JS, Choi JH, Ham JH, Min YK, Yang HM, Kazuhiro S, Matsumoto

  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):21-25.
People in tropics have the ability to tolerate heat by residential permanence in the tropics. Previously, we have shown that African and Thai subjects who lived for whole their lives...
Decreased Expression of PTEN in Olfactory Bulb of Rat Pub after Naris Closure

Cho J, Lee SH, Lee GH, Chun W, Park YT, Lim SY, Kim SS

  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):17-20.
PTEN (phosphatase and tensin homolog) is a dual specific phosphatase antagonizing phosphoinositide 3-kinase activity, and has first been cloned as a tumor suppressor for glioma. Although the role of PTEN...
Nitric Oxide (NO) Inhibites the Neuronal Activities in the Rat Nucleus Tractus Solitarius

Kim MW, Park MS, Ryu SY, Jung JY, Jeong YJ, Kim SH, Kim MS, Kim WJ

  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):7-15.
Nitric oxide (NO) system has been implicated in a wide range of physiological functions in the nervous system. However, the roleof NO in regulating the neural activity in the gustatory...
Postischemic Treatment with Aminoguanidine Inhibits Peroxynitrite Production in the Rat Hippocampus Following Transient Forebrain Ischemia

Choi YS, Yoon YH, Lee JE, Cho KO, Kim SY, Lee SB

  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):1-5.
Transient forebrain ischemia results in the delayed neuronal death in the CA1 area of the hippocampus. The present study was performed to determine effects of aminoguanidine, a selective iNOS inhibitor,...

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