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Effects of Dopamine on Intracellular pH in Opossum Kidney Cells

Kang KW, Kim YK

  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):187-191.
Na+/H+ exchanger (NHE) has a critical role in regulation of intracellular pH (pHi) in the renal proximal tubular cells. It has recently been shown that dopamine inhibits NHE in the...
Sympathetic Regulation of Aquaporin Water Channels in Rat Kidney

Lee J, Yoo K, Oh Y, Lim DY

  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):181-185.
Whether there exists a sympathetic neural regulation on the aquaporin (AQP) channels in the kidney was examined. Male Sprague-Dawley rats were used. They were renal nerve denervated by stripping the...
Neurotrophic and Neuritogenic Effects of Water Extracts of Rhizoma of Coptis chinensis Franch in PC12 Cells

Kwon GY, Choe BK, Kim SK

  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):175-179.
Coptis chinensis (CC) is one of the traditional herbs used in Oriental medicine for the treatment of gastrointestinal disorders, anxiety, and insomnia. In this study, neurotrophic and neuritogenic effects of...
Effects of gamma-Aminobutyric Acid on Intrinsic Cholinergic Action in Exocrine Secretion of Isolated, Perfused Rat Pancreas

Park YD, Park HS, Cui ZY, Park HJ

  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):169-174.
gamma-Aminobutyric acid (GABA) has been reported to enhance exocrine secretion evoked not only by secretagogues but also by intrinsic neuronal excitation in the pancreas. The pancreas contains cholinergic neurons abundantly...
Transduction of Tat-Superoxide Dismutase into Insulin-producing MIN6N Cells Reduces Streptozotocin-induced Cytotoxicity

Choung IS, Eum WS, Li MZ, Sin GS, Kang JH, Park J, Choi SY, Kwon HY

  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):163-168.
The reactive oxygen species (ROS) are considered to be an important mediator in pancreatic beta cell destruction, thereby triggering the development of insulin-dependent diabetes mellitus. In the present study, HIV-1...
Alteration of Substrate Specificity by Common Variants, E158K/E308G and V257M, in Human Hepatic Drug-metabolizing Enzyme, Flavin-containing Monooxygenase 3

Lee JK, Kang JH, Cha YN, Chung WG, Park CS

  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):157-162.
Our earlier studies found a significant correlation between the activities of ranitidine N-oxidation catalyzed by hepatic flavin-containing monooxygenase (FMO) and the presence of mutations in exon 4 (E158K) and exon...
Comparison of Vasodilator Effects of Platycodin D and D3 in Rats

Lim DY, Kim BC, Lee EB

  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):149-155.
The aim of the present study was to examine the effects of platycodin D and D3, which are active components derived from the roots of Platycodon grandiflorum A. DC., on...
Consistent and Specific Suppression of Mucin Release from Cultured Hamster Tracheal Surface Epithelial Cells by Poly-L-Lysine

Lee CJ, Lee JH, Seok JH, Hur GM, Park JS, Bae S, Jang HS, Park SC

  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):143-147.
Poly-L-lysine (PLL) was reported to suppress mucin release from airway goblet cells during 30 min treatment period. In this study, we investigated whether PLL consistently suppresses mucin release from cultured...
Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis

So I, Ashmole I, Soh H, Park C, Spencer P, Leyland M, Stanfield

  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):131-142.
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or...
Effects of Chlorhexidine Digluconate on Rotational Rate of n- (9-Anthroyloxy) stearic Acid in Porphyromonas ginginvalis Outer Membranes

Jang HO, Cha SK, Lee C, Choi MG, Huh SR, Shin SH, Chung IK, Yun I

  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):125-130.
The aim of this study was to provide a basis for studying the molecular mechanism of pharmacological action of chlorhexidine digluconate. Fluorescence polarization of n- (9-anthroyloxy) stearic acid was used...
Effects of Local Anesthetics on Rotational Mobility of n- (9-Anthroyloxy) stearic Acid in Neuronal Membranes

Jang HO, Lee C, Choi MG, Shin SH, Chung IK, Yun I

  • Korean J Physiol Pharmacol.
  • 2003 Jun;7(3):119-124.
To elucidate the molecular mechanism of pharmacological action of local anesthetics, we studied membrane actions of tetracaine, bupivacaine, lidocaine, prilocaine and procaine. Fluorescence polarization of n- (9-anthroyloxy) stearic acid (n-AS)...

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