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9 results

Effects of Noradrenaline on the Membrane Potential of Prostatic Neuroendocrine Cells of Rat

Kim JH, Shin SY, Uhm DY, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2003 Feb;7(1):47-52.
The prostate gland contains numerous neuroendocrine cells that are believed to influence the function of the prostate gland. Our recent study demonstrated the expression of both alpha 1- and alpha...
Dietary Ascorbate Supplementation Reduces Oxidative Tissue Damage and Expression of iNOS in the Kidney of Streptozotocin Induced Diabetic Rats

Choi MS, Jang YY, Lee WS, Song JH, Shin YK

  • Korean J Physiol Pharmacol.
  • 2003 Feb;7(1):39-45.
Reactive oxygen species (ROS) have been suggested to be contributory factors in complications of diabetes mellitus. In the present study, we investigated the generation of superoxide, the lipid peroxide level...
Overexpressed Mitochondrial Thioredoxin Protects PC12 Cells from Hydrogen Peroxide and Serum-deprivation

Lee YS, Yu SA

  • Korean J Physiol Pharmacol.
  • 2003 Feb;7(1):33-37.
Oxidative damage to mitochondria is a critical mechanism in necrotic or apoptotic cell death induced by many kinds of toxic chemicals. Thioredoxin (Trx) family proteins are known to play protective...
Apo-1/Fas (CD95) Gene Polymorphism in Korean Hepatocellular Carcinoma Patients

Kim SS, Hong SJ, Ahn YG, Kim BS, Yuh YJ, Han KY, Lee HJ, Chung JH, Yim SV, Cho J, Park YH

  • Korean J Physiol Pharmacol.
  • 2003 Feb;7(1):29-31.
It is well known that different expression of Apo-1/Fas (CD95) plays important roles in various tumors and hepatocellular carcinoma (HCC) pathogenesis. Apo-1/Fas mediated apoptosis is one of the important pathways...
4-Aminopyridine Inhibits the Large-conductance Ca2+ -activated K+ Channel (BKCa) Currents in Rabbit Pulmonary Arterial Smooth Muscle Cells

Bae YM, Kim A, Kim B, Cho SI, Kim J, Earm YE

  • Korean J Physiol Pharmacol.
  • 2003 Feb;7(1):25-28.
Ion channel inhibitors are widely used for pharmacological discrimination between the different channel types as well as for determination of their functional role. In the present study, we tested the...
Thiol-dependent Redox Mechanisms in the Modification of ATP-Sensitive Potassium Channels in Rabbit Ventricular Myocytes

Han J, Kim N, Cuong DV, Kim C, Kim E

  • Korean J Physiol Pharmacol.
  • 2003 Feb;7(1):15-23.
Cellular redox state is known to be perturbed during ischemia and that Ca2+ and K+ channels have been shown to have functional thiol groups. In this study, the properties of...
Inhibition of DNA-dependent Protein Kinase by Blocking Interaction between Ku Complex and Catalytic Subunit of DNA-dependent Protein Kinase

Kim CH, Cuong DV, Kim JS, Kim N, Kim E, Han J

  • Korean J Physiol Pharmacol.
  • 2003 Feb;7(1):9-14.
Recent studies indicated that cancer cells become resistant to ionizing radiation (IR) and chemotherapy drugs by enhanced DNA repair of the lesions. Therefore, it is expected to increase the killing...
Acute Effect of Alcohol and Nicotine on 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal and Median Raphe of Rats

Jang MH, Shin MC, Chang HK, Lee TH, Kim KH, Kim YJ, Kim CJ

  • Korean J Physiol Pharmacol.
  • 2003 Feb;7(1):5-8.
Alcohol abuse and cigarette smoking have been on the rise worldwide and it has been reported that alcohol and nicotine influence serotonergic neuronal activity in the dorsal raphe. Serotonin (5-hydroxytryptamine,...
Regulation of [3H]Norepinephrine Release by Opioids in Human Cerebral Cortex

Woo RS, Shin BS, Kim CJ, Shin MS, Jeong MS, Zhao RJ, Kim KW

  • Korean J Physiol Pharmacol.
  • 2003 Feb;7(1):1-3.
To investigate the receptors mediating the regulation of norepinephrine (NE) release in human cerebral cortex slices, we examined the effects of opioid agonists for mu-, delta-, and kappa -receptors on...

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