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13 results

A Possible Role of Kainate Receptors in C2C12 Skeletal Myogenic Cells

Park JY, Han J, Hong SG

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):375-379.
Ca2+ influx appears to be important for triggering myoblast fusion. It remains, however, unclear how Ca2+ influx rises prior to myoblast fusion. Recently, several studies suggested that NMDA receptors may...
Carrageenan-Induced Hyperalgesia Is Partially Alleviated by Endomorphin-1 Locally Delivered into Inflamed Paws In Rat

Lee SE, Shin HK

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):369-373.
This study was performed to test whether endomorphin-1 has analgesic effect, when locally administrated into inflamed peripheral tissue. Carrageenan suspension (0.5%) was injected intraplantarly into the right paw of Sprague-Dawley...
Caffeic Acid Phenethyl Ester Inhibits the PKC-Induced IL-6 Gene Expression in the Synoviocytes of Rheumatoid Arthritis Patients

Hur GM, Hwang YB, Lee JH, Bae SH, Park JS, Lee CJ, Seok JH

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):363-368.
To gain insight on the role of pro-inflammatory cytokines in the pathogenesis and treatment of rheumatoid arthritis (RA), the phorbol 12-myristate 13-acetate (PMA) -induced IL-6 gene expression and the effect...
The Effect of Carbon Monoxide on L-type Calcium Channel Currents in Human Intestinal Smooth Muscle Cells

Lim I

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):357-362.
Carbon monoxide (CO) is low molecular weight oxide gas that is endogenously produced under physiological conditions and interacts with another gas, nitric oxide (NO), to act as a gastrointestinal messenger....
Cooperation of Gbeta and Galphaq Protein in Contractile Response of Cat Lower Esophageal Sphincter (LES)

Sohn UD, Lee TS

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):349-355.
We previously shown that LES contraction depends on M3 receptors linked to PTX insensitive Gq protein and activation of PLC. This results in production of IP3, which mediates calcium release,...
Stretch-activated K+ Channels in Rat Atrial Myocytes

Youm JB

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):341-348.
Mechanical stimuli to the cardiac myocytes initiate many biochemical and physiological events. Stretch-activated cation channels have been suggested to mediate these events. In this study, cell-attached and inside-out excised-patch clamp...
Reduction of Muscarinic K+ Channel Activity by Transferrin in Ischemic Rat Atrial Myocytes

Park KT, Kang D, Han J, Park JY, Hur CG, Hong SG

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):333-339.
It has been demonstrated that an unidentified cytosolic factor (s) reduces K (ACh) channel function. Therefore, this study attempted to elucidate the cytosolic factor. Fresh cytosol isolated from normal heart...
Involvement of Oxidative Stress and Poly (ADP-ribose) Polymerase Activation in 3-Nitropropionic Acid-induced Cytotoxicity in Human Neuroblastoma Cells

Nam E, Lee YJ, Oh YA, Jung JA, Im HI, Koh SE, Maeng S, Joo WS, Kim YS

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):325-331.
3-Nitropropionic acid (3-NP) inhibits electron transport in mitochondria, leading to a metabolic failure. In order to elucidate the mechanism underlying this toxicity, we examined a few biochemical changes possibly involved...
Electrophysiological and Morphological Classification of Inhibitory Interneurons in Layer II/III of the Rat Visual Cortex

Rhie DJ, Kang HY, Ryu GR, Kim MJ, Yoon SH, Hahn SJ, Min DS, Jo YH, Kim MS

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):317-323.
Interneuron diversity is one of the key factors to hinder understanding the mechanism of cortical neural network functions even with their important roles. We characterized inhibitory interneurons in layer II/III...
SM709, Ingredient of Antimelanogenic Bamboo Extract, Blocks Endothelin-1-induced [Ca2+]i Increase in Human Melanocytes

Kim SH, Lee KM, Kim HS, Lee GS, Jeon BH, Kim KJ, Park JB

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):311-316.
Endothelins secreted from keratinocytes are intrinsic mitogens and melanogens of human melanocytes in UVB-induced hyperpigmentation. To elucidate the cellular mechanism of antimelanogenic activity of bamboo extract, the effects of three...
Curcumin Attenuates Glial Cell Activation But Cannot Suppress Hippocampal CA3 Neuronal Cell Death in i.c.v. Kanic Acid Injection Model

Cho J, Kong PJ, Chun W, Moon YO, Park YT, Lim SY, Kim SS

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):307-310.
Kainic acid (KA) is a structural analogue of glutamate that interacts with specific presynaptic and postsynaptic receptors to potentiate the release and excitatory actions of glutamate. Systemic or intracerebroventricular (i.c.v.)...
Modulation of Amygdala Synaptic Transmission by Metabotropic Glutamate Receptors

Kim JH, Park EJ, Chang DJ, Choi S

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):303-306.
Metabotropic glutamate receptors (mGluRs), classified into three groups (group I, II, III), play a critical role in modulation of synaptic transmission at central and peripheral synapses. In the present study,...
Inhibitory Modulation of 5-Hydroxytryptamine on Corticostriatal Synaptic Transmission in Rat Brain Slice

Choi SJ, Chung WS, Kim KJ, Sung KW

  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):295-301.
Striatum plays a crucial role in the movement control and habitual learning. It receives an information from wide area of cerebral cortex as well as an extensive serotonergic (5-hydroxytryptamine, 5-HT)...

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