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10 results

Selective Cytotoxicity of Novel Platinum (II) Coordination Complexes on Human Bladder Cancer Cell-Lines and Normal Kidney Cells

Kim JT, Rho YS, Jung JC

  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):111-117.
Cisplatin is often effective in cancer treatment, but its clinical use is limited because of its nephrotoxicity. We have synthesized new platinum (II) coordination complexes (PC-1 & PC-2) containing trans-l...
Involvement of NAD (P) H Oxidase in a Potential Link between Diabetes and Vascular Smooth Muscle Cell Proliferation

Jeong HY, Yun MR, Kim CD

  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):103-110.
The cellular mechanisms that contribute to the acceleration of atherosclerosis in diabetes are poorly understood. Therefore, the potential mechanisms involved in the diabetes-dependent increase in vascular smooth muscle cell (VSMC)...
Altered Expression of Aquaporins in Rat Submandibular Glands after Parasympathetic Denervation

Jung JY, Byun KO, Kim WJ

  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):97-102.
The salivary glands produce 1.5L of fluid per day. As in other exocrine organs, the general mechanism in the salivary glands is that water movement occurs secondary to osmotic driving...
Promoting Effect of a Mixture of 8 Herbal Extracts (SPELA 707) on Hair Growth

Choi EY, Park SN, Park SU, Choi S, Ro BI, Chung MH

  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):91-96.
In Korean folk medicine, several herbs, Glycyrrhizae Radix, Persicae Semen, Salviae Radix, Angelicae Gigantis Radix, Zanthoxyli Fructus, Ginseng Radix Alba, Cnidii Rhizoma, and Carthami Flos, are known to enhance blood...
Changes in Vestibular Nerve Activity Following Acute Hypotension in Rats

Park BR, Kim MS, Yee GH, Moon MJ, Kim JH, Jin YZ, Kim YS

  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):85-90.
The basic mechanism for the excitation of the peripheral vestibular receptors following acute hypotension induced by sodium nitroprusside (SNP) or hemorrhage was investigated in anesthetized rats. Electrical activity of the...
Modulation of Pituitary Somatostatin Receptor Subtype (sst1-5) mRNA Levels by Growth Hormone (GH) -Releasing Hormone in Purified Somatotropes

Park S, Park H, Lee M, Sohn S, Kim E, Jung J, Frohman LA, Kineman RD

  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):79-84.
We have previously reported that expression of the somatostatin receptor subtypes, sst1-5, is differentially regulated by growth hormone (GH) -releasing hormone (GHRH) and forskolin (FSK), in vitro. GHRH binds to...
Roles of Nitric Oxide in Vestibular Compensation

Jeong HS, Jun JY, Park JS

  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):73-78.
The effects of nitric oxide on the vestibular function recovery following unilateral labyrinthectomy (UL) were studied. Sprague-Dawley male rats, treated with nitric oxide liberating agent sodium nitroprusside (SNP) and NOS...
Inhibition of NF-kappaB Activation Increases Oxygen-Glucose Deprivation-Induced Cerebral Endothelial Cell Death

Lee J, Kim CH, Shim KD, Ahn YS

  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):65-72.
Increasing evidences suggest that ischemia-induced vascular damage is an integral step in the cascade of the cellular and molecular events initiated by cerebral ischemia. In the present study, employing a...
Inhibitory and Excitatory Postsynaptic Currents of Medial Vestibular Nucleus Neurons of Rats

Chun SW, Choi JH, Park BR

  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):59-64.
The medial vestibular nucleus (MVN) neurons are controlled by excitatory synaptic transmission from the vestibular afferent and commissural projections, and by inhibitory transmission from interneurons. Spontaneous synaptic currents of MVN...
Mechanism of Glutamate-induced[Ca2+]i Increase in Substantia Gelatinosa Neurons of Juvenile Rats

Jung SJ, Choi JS, Kwak J, Kim J, Kim JW, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2003 Apr;7(2):53-58.
The glutamate receptors (GluRs) are key receptors for modulatory synaptic events in the central nervous system. It has been reported that glutamate increases the intracellularCa (2+) concentration ([Ca2+]i) and induces...

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