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Blockade of p38 Mitogen-activated Protein Kinase Pathway Inhibits Interleukin-6 Release and Expression in Primary Neonatal Cardiomyocytes

Chae HJ, Kim HK, Lee WK, Chae SW

  • Korean J Physiol Pharmacol.
  • 2002 Dec;6(6):319-325.
The induction of interleukin-6 (IL-6) using combined proinflammatory agents (LPS/IFN-gamma or TNF-alpha/IFN-gamma) was studied in relation to p38 mitogen-activated protein kinase (MAPK) and NF-kappaB transcriptional factor in primary neonatal cardiomyocytes....
Altered Secretory Pattern of Pancreatic Enzymes and Gastrointestinal Hormones in Streptozotocin-induced Diabetic Rats

Kim MJ, Ryu GR, Yi SY, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH

  • Korean J Physiol Pharmacol.
  • 2002 Dec;6(6):311-317.
This study was performed to investigate the pancreatic exocrine dysfunction in streptozotocin- induced diabetic rats. Changes in pancreatic enzymes secretion and in pancreatic enzymes content were observed. The output and...
Characterization of Intermediate Conductance K+ Channels in Submandibular Gland Acinar Cells

Cho SM, Piao ZG, Kim YB, Kim JS, Park K

  • Korean J Physiol Pharmacol.
  • 2002 Dec;6(6):305-309.
There are some evidences that K+ efflux evoked by muscarinic stimulation is not mainly mediated by large conductance K+ (BK) channels in salivary gland. In this experiment, we therefore characterised...
Normal Anxiety, Fear and Depression-related Behaviors in Mice Lacking alpha-Calcitonin Gene-Related Peptide

Lee J

  • Korean J Physiol Pharmacol.
  • 2002 Dec;6(6):299-304.
Calcitonin gene-related peptide (CGRP) expressing neurons are distributed widely throughout the central and peripheral nervous systems. Due to its distribution and pharmacological studies, CGRP has been implicated to be involved...
Neuroprotective Effect of 8-OH-DPAT on Long-term Sequelae from Prenatal Ischemia in Rats

Lee S, Zhang TY, Kim GT, Kim HS, Lee JD, Jahng JW, Kim DG

  • Korean J Physiol Pharmacol.
  • 2002 Dec;6(6):293-297.
The role of 5-hydroxytryptamine (5-HT)1A receptor activity in prenatal ischemia was studied, by injecting 8-hydroxy-dipropylaminotetraline (8-OH-DPAT; 50 microgram/kg, s.c.), a 5-HT1A agonist on gestation day 17, and 30 min later...
Changes in Excitability of Neurons in Rat Medial Vestibular Nucleus Following Vestibular Neurectomy

Chun SW, Choi JH, Lee SH, Park BR

  • Korean J Physiol Pharmacol.
  • 2002 Dec;6(6):287-291.
Intrinsic excitabilities of acutely isolated medial vestibular nucleus (MVN) neurons of rats with normal labyrinth and with undergoing vestibular compensation from 30 min to 24 h after unilateral vestibular deafferentation...
Ceramide is Involved in MPP+ -induced Cytotoxicity in Human Neuroblastoma Cells

Nam EJ, Lee HS, Lee YJ, Joo WS, Maeng S, Im HI, Park CW, Kim YS

  • Korean J Physiol Pharmacol.
  • 2002 Dec;6(6):281-286.
To understand the cytotoxic mechanism of MPP+, we examined the involvement of ceramide in MPP+ -induced cytotoxicity to human neuroblastoma SH-SY5Y cells. When SH-SY5Y cells were exposed to MPP+, MPP+...

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