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10 results

THI 52 inhibits inducible nitric oxide synthase gene expression in RAW 264.7 cells and rat lung tissue by lipopolysaccharide

Lee BK, Park MK, Seo HG, Yun-Choi H, Lee DH, Chang KC

  • Korean J Physiol Pharmacol.
  • 2001 Oct;5(5):443-449.
Previously we reported that THI 52 inhibits tumor necrosis factor (TNF)-alpha mRNA expression in mouse peritoneal macrophages exposed to LPS plus IFN-gamma. In the present study, the effects of THI...
Expression of ATP-sensitive potassium channel and sulfonylurea receptor in neonate and adult rat tissues

Lee SY, Lee H, Lee MH, Ryu PD

  • Korean J Physiol Pharmacol.
  • 2001 Oct;5(5):433-441.
The ATP-sensitive potassium (KATP) channel is a member of inward rectifier potassium channel (Kir) that is inhibited by intracellular ATP and functions in close relation to sulfonylurea receptors (SUR). Although the molecular mechanism...
Differential modulation of exogenous and endogenous adenosine-induced coronary vasodilation by dipyridamole

Kim YH, Kim CH, Kim MS

  • Korean J Physiol Pharmacol.
  • 2001 Oct;5(5):423-431.
Some recent investigations revealed that vasodilatory action of adenosine is mainly not mediated by surface A2 receptor and suggested the existence of an intracellular action site. In the present study, we tried to...
Altered electrophysiological properties of coronary artery in isoprenaline-induced cardiac hypertrophy

Kim N, Han J, Kim E

  • Korean J Physiol Pharmacol.
  • 2001 Oct;5(5):413-421.
An impaired smooth muscle cell (SMC) relaxation of coronary artery by alteration of K+ channels would be the most potential explanation for reduced coronary reserve in left ventricular hypertrophy (LVH), however, this possibility...
Constitutive expression and changes of cytochrome P450 isozymes mRNAs by vehicles (petrolatum, DMSO, ethanol) in rat skin using semi-quantitative RT-PCR

Lee AY, Lee KH, Ko DS, Chey WY

  • Korean J Physiol Pharmacol.
  • 2001 Oct;5(5):407-412.
Many drugs are primarily metabolized by the cytochrome P450s (CYPs). Drug metabolites would be important allergens for adverse drug reactions such as drug eruptions. Skin tests with a suspected drug have conducted to...
Unchanged protein level of ryanodine receptor but reduced (3H) ryanodine binding of cardiac sarcoplasmic reticulum from diabetic cardiomyopathy rats

Lee EH, Seo YJ, Kim YH, Kim HW

  • Korean J Physiol Pharmacol.
  • 2001 Oct;5(5):397-405.
The ryanodine receptor, a Ca2+ release channel of the sarcoplasmic reticulum (SR), is responsible for the rapid release of Ca2+ that activates cardiac muscle contraction. In the excitation-contraction coupling cascade, activation of SR...
Neuroprotection of lithium is associated with inhibition of Bax expression and caspase 8 activation

Kwon GY, Kim SK

  • Korean J Physiol Pharmacol.
  • 2001 Oct;5(5):389-396.
Neuroprotective properties of lithium were investigated by using in vivo NMDA excitotoxicity model. The appearance of TUNEL positive cells was prominent within 24 h of NMDA (70 mg/kg, i.p.) injection in the regions...
KR 31378, a potent antioxidant, inhibits apoptotic death of A7r5 cells

Kim KY, Kim BG, Kim SO, Yoo SE, Hong KW

  • Korean J Physiol Pharmacol.
  • 2001 Oct;5(5):381-388.
This work describes the pharmacological inhibition by KR 31378 and its acetyl metabolite, KR 31612, of the apoptotic cell death induced by H2O2 in the A7r5 cells. Exposure of A7r5 cells to...
The inhibitory effect of opioid on the hyperpolarization-activated cation currents in rat substantia gelatinosa neurons

Seol GH, Kim J, Cho SH, Kim WK, Kim JW, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2001 Oct;5(5):373-380.
The action of opioid on the hyperpolarization-activated cation current (Ih) in substantia gelatinosa neurons were investigated by using whole-cell voltage-clamp recording in rat spinal brain slices. Hyperpolarizing voltage steps revealed slowly activating currents...
Functional abnormalities of HERG mutations in long QT syndrome 2 (LQT2)

Hiraoka M

  • Korean J Physiol Pharmacol.
  • 2001 Oct;5(5):367-371.
The chromosome 7-linked long QT syndrome (LQT2) is caused by mutations in the human ether-a-go-go-related gene (HERG) that encodes the rapidly activating delayed rectifier K+ current, IKr, in cardiac myocytes. Different types of...

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