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Diclofenac inhibits IFN-gamma plus lipopolysaccharide-induced iNOS gene expression via suppression of NF-kappaB activation in RAW 264.7 macrophages

Bae SH, Ryu YS, Hong JH, Park JC, Kim YM, Seok JH, Lee JH, Hur GM

  • Korean J Physiol Pharmacol.
  • 2001 Dec;5(6):521-527.
Diclofenac, a phenylacetic acid derivative, is a widely used non-steroidal anti-inflammatory drug (NSAID) to provide effective relief of inflammation and pain. Nitric oxide (NO) synthesized by inducible nitric oxide synthase...
Nimodipine as a potential pharmacological tool for characterizing R-type calcium currents

Oh SB

  • Korean J Physiol Pharmacol.
  • 2001 Dec;5(6):511-519.
Nimopidine, one of dihydropyridine derivatives, has been widely used to pharmacologically identify L-type Ca currents. In this study, it was tested if nimodipine is a selective blocker for L-type Ca...
Effect of staurosporine on the long-term secretion of catecholamines induced by various secretagogues in cultured bovine adrenal medullary chromaffin cells

Choi SS, Suh HW

  • Korean J Physiol Pharmacol.
  • 2001 Dec;5(6):503-510.
Long-term treatment of cultured bovine adrenal medullary chromaffin (BAMC) cells with arachidonic acid (100 muM), angiotesnin II (100 nM), prostaglandin E2 (PGE2; 10 muM), veratridine (2 muM) or KCl (55...
Expression of neurotensin/neuromedin N precursor in murine mast cells

Ahn HJ, Cho JJ

  • Korean J Physiol Pharmacol.
  • 2001 Dec;5(6):495-501.
We have cloned the mouse neurotensin/neuromedin N (NT/N) gene from the murine mast cell line C1.MC/C57.1 for the first time. The murine NT/N cDNA clone consisted of 765 nucleotides and...
Forward-mode Na+ - Ca2+ exchange during depolarization in the rat ventricular myocytes with high EGTA

Kim EG, Ko CM

  • Korean J Physiol Pharmacol.
  • 2001 Dec;5(6):487-494.
During depolarization, extrusion of Ca2+ from sarcoplasmic reticulum through forward-mode Na+ - Ca2+ exchange was studied in the rat ventricular myocytes patch-clamped in whole-cell configuration. In order to confine the...
Mediation of N-methyl-D-aspartate on neuropeptide Y expression induced by morphine in mouse cerebellum

Kwon GY, Kim SK

  • Korean J Physiol Pharmacol.
  • 2001 Dec;5(6):479-485.
The existence of opioid receptors in mammalian cerebellum except human, has not been clearly understood. In the present study, we found that NPY was inducible by morphine in the mouse...
Regional heterogeneity of morphological changes in cultured rat astrocytes

Won CK, Oh YS

  • Korean J Physiol Pharmacol.
  • 2001 Dec;5(6):467-477.
We examined astrocyte regional heterogeneity in their morphological changes in response to various stimuli. Astrocytes were cultured from six different neonatal rat brain regions including cerebral cortex, hippocampus, cerebellum, mid...
Responsiveness of dendrites to the glutamate applied focally with pressure ejector and iontophoresis into hippocampal slices

Kim JH, Shin HK, Chang HJ, Kim HY

  • Korean J Physiol Pharmacol.
  • 2001 Dec;5(6):457-466.
Glutamate is the most common excitatory amino acid in the brain. Responsiveness of dendrites to the glutamate greatly varies depending on the application sites. Especially, a point of the maximal...
Effect of kainic acid on the phosphorylation of mitogen activated protein kinases in rat hippocampus

Won JS, Lee JK, Choi SS, Song DK, Huh SO, Kim YH, Suh HW

  • Korean J Physiol Pharmacol.
  • 2001 Dec;5(6):451-456.
In rat hippocampus, kainic acid (KA; 10 mg/kg; i.p.) increased the phosphorylated forms of ERK1/2 (p-ERK1/2) and Jun kinase1 (p-JNK1), but not p-JNK2 and p38 (p-p38). The preadministration with cycloheximide...

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