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10 results

Effect of propofol on ion channels in acutely dissociated dorsal raphe neuron of Sprague-Dawley rats

Lee BJ, Kwon MI, Shin MC, Kim YJ, Kim CJ, Kim SA, Kim EH, Chung JH

  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):189-197.
To investigate propofol's effects on ionic currents induced by gamma-aminobutyric acid (GABA) and glycine as well as on those produced by the nicotinic acetylcholine- and glutamate-responsive channels, rat dorsal raphe neurons were acutely...
Antidiabetic activity and mechanisms of acarbose in KKAy mice

Kim YL, Chung SH

  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):183-188.
To elucidate antidiabetic effect and mechanism(s) of acarbose in a polygenic spontaneous hyperglycemic and hyperinsulinemic diabetic animal model, KKAy mice, acarbose was administered orally for 4 weeks and effects on body weight, plasma...
Indomethacin induces apoptosis in NCI-H1299 human lung carcinoma cells

Kim BS, Kim SA, Kim MJ, Lee HJ, Park SJ, Jung JC, Kim CJ, Yim SV, Chung JH

  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):177-181.
Recently, nonsteroidal anti-inflammatory drugs (NSAIDs) have been found to be useful in the chemoprevention of colon cancer. To investigate whether indomethacin, an NSAIDs, induces apoptosis and thus assess the possibility of its application...
Activation of ATP-sensitive potassium channels by the predominant metabolite of isoflurane in rabbit ventricular myocytes

Han J, Kim NR, Kim EY, Kim SJ, Cho KH

  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):165-175.
Background: Recent in vivo experimental evidence suggests that isoflurane-induced cardioprotection may involve KATP channel activation. However, it was demonstrated that isofluran inhibited KATP channel activities in the inside-out patch mode. To explain this discrepancy,...
Block of ATP-sensitive K+ channels expressed in Xenopus oocytes by dimethyl sulfoxide

Park JB, Chae SW

  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):157-163.
The effects of dimethyl sulfoxide (DMSO) were studied in two groups of Xenopus oocytes, one expressing ATP sensitive K+ (KATP) channel comprised of sulfonylurea receptor SUR1 and inwardly rectifying K+ channel subunit Kir6.2,...
The alteration of Ca2+-activated K+ channels in coronary arterial smooth muscle cells isolated from isoproterenol-induced cardiac hypertrophy in rabbit

Kim N, Han J, Kim EY

  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):147-156.
It has been proposed that Ca2+-activated K+ (KCa) channels play an essential role in vascular tone. The alterations of the properties of coronary KCa channels have not been studied as a possible...
Modulation of L-type Ca2+ channel currents by various protein kinase activators and inhibitors in rat clonal pituitary GH3 cell line

Bae YM, Baek HJ, Cho HN, Earm YE, Ho WK

  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):139-146.
L-type Ca2+ channels play an important role in regulating cytosolic Ca2+ and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated...
Effects of pretreatment of serotonin synthesis inhibitor p-chlorophenylalanine on lipopolysaccharide-induced anorexia in rats

Park SY, Kim BS, Back SS

  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):133-138.
In the present study, we investigated the effect of pretreatment of p-chlorophenylalanine (PCPA), inhibitor of serotonin synthesis, on lipopolysaccharide (LPS)-induced anorexia in rats. First of all, effects of PCPA injection on food intake...
Electrical stimulation can facilitate vestibular compensation following unilateral labyrinthectomy in rats

Park BR, Kim JO, Kim MS, Lee MY, Kim JH, Jin YZ, Choi MA

  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):123-131.
To investigate the effects of electrical stimulation on vestibular compensation, which is the recovery of vestibular symptoms following unilateral labyrinthectomy (UL), intermittent electrical stimulation was applied to the injured vestibular portion in Sprague-Dawley...
Molecular aspects of organic ion transporters in the kidney

Cha SH, Hitoshi E

  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):107-122.
A function of the kidney is elimination of a variety of xenobiotics ingested and wasted endogenous compounds from the body. Organic anion and cation transport systems play important roles to protect the...

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