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11 results

Comparison of the determinants in the differences in force-frequency relationships between rat and rabbit left atria

Ko CM, Kim SJ

  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):417-425.
The underlying mechanism commonly applicable for both the positive and negative force-frequency relationships (FFR) was pursued in left atria (LA) of rat and rabbit. The species differences in the roles of Na+/Ca2+ exchanger...
Different effects of dopamine on differential rotational mobility between inner and outer monolayer of synaptosomal plasma membrane vesicles isolated from bovine brain

Kim HG, Choi CH, Kim IS, Chung IK, Cho GJ, Jang HO, Yun I

  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):409-415.
Fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene (DPH) was used to evaluate the effects of dopamine cntdot HCl on the range of the rotatioanl mobility of bulk bilayer structure of the synaptosomal plasma membrane vesicles (SPMV)...
Stationary outward and transient Ca2+-dependent currents in hamster oocytes

Kim YM, Han JH, Kim JS, Hong SG

  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):403-408.
The outward currents elicited in hamster eggs by depolarizing pulses were studied. The currents appeared to comprise at least two components, a transient outward component (Ito) and a steady-state outward component (Iinfin). Ito...
Postnatal changes in atrial compliance and stretch-induced ANP secretion in rabbits

Kim SH, Lee KS, Kim SZ, Seul KH, Cho KW

  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):393-401.
To define the postnatal changes in ANP secretion in response to mechanical stretch and atrial compliance, experiments have been done in perfused nonbeating rabbit atria with different ages: 1-day, 1-, 2-, 3-, 4-,...
Alteration of 4-aminopyridine-sensitive, voltage-dependent K+-channel in arterial smooth muscle cells of one-kidney, one-clip Goldblatt hypertensive rats

Kim HS, Kim SH, Jeon BH, Chang SJ

  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):385-391.
Using the patch-clamp technique, we investigated the alteration of 4-aminopyridine(4-AP)-sensitive, voltage-dependent K+ channel (KV) in the mesenteric arterial smooth muscle cell (MASMC) of renovascular hypertensive model, one-kidney one-clip Goldblatt hypertensive rat (GBH). To isolate...
Diminished vascular guanylyl cyclase activity in deoxycorticosterone acetate-salt hypertension

Lee JU, Hong JH

  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):379-383.
Pathophysiological implications of the vascular nitric oxide (NO)/cGMP pathway in hypertension were investigated. Sprague-Dawley rats were made deoxycorticosterone acetate (DOCA)-salt hypertensive for six weeks. The protein expression of endothelial constitutive NO synthase (ecNOS) and...
Nitroxergic nerve relaxes rat gastric smooth muscle by NO-cGMP pathway

Yoon YS, Choi HC, Jung YS, Kim JH, Lee KY, Sohn UD, Ha JH, Kim WJ

  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):369-378.
This study was undertaken to investigate an involvement of nitroxergic innervation in gastric smooth muscle of rat. Isometric tension study, the measurement of single cell length, NADPH diaphorase stain of smooth muscle layers...
Amperozide decreases cocaine-induced increase in behavior and immediate early gene expression in the dorsal striatum

Choe ES, Kim JY

  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):361-367.
Cocaine functions as indirect dopamine and serotonin (5-hydroxytryptamine, 5HT) agonists and induces genomic and behavioral alterations in the striatum. Previously we demonstrated that ritanserin, a 5HT2/1C receptor antagonist, is not responsible for cocaine-induced behavioral...
Ritanserin, a 5HT2/1C receptor antagonist, does not block cocaine-induced behavioral alterations and zif268 mRNA expression in the striatum of the rats

Choe ES, Kim JY

  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):355-359.
Cocaine induces immediate early gene expression and behavioral changes by blocking dopamine transporters in the terminals of nigrostriatal neurons in the striatum. The pharmacological role of serotonin 2/1C (5HT2/1C) receptors in cocaine-induced expression...
Glucose/oxygen deprivation induces release of (3H)5-hydroxytryptamine associated with synapsin 1 expression in rat hippocampal slices

Park EM, Chu SH, Lee KE

  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):347-353.
It has been well documented that a massive release of not only glutamate but also other neurotransmitters may modulate the final responses of nerve cells to the ischemic neuronal injury. But there...
p38 MAPK and NF-kappaB are required for LPS-induced RANTES production in immortalized murine microglia (BV-2)

Jang SB, Lee KH

  • Korean J Physiol Pharmacol.
  • 2000 Oct;4(5):339-346.
Using murine immortalized microglial cells (BV-2), we examined the regulation of RANTES production stimulated by lipopolysaccharide (LPS), focusing on the role of mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB. The result showed...

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