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11 results

Impaired endothelium-dependent relaxation is mediated by reduced production of nitric oxide in the streptozotocin-induced diabetic rats

Park KS, Kim CS, Kang SW, Park JB, Kim KJ, Chang SJ, Jeon BH

  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):263-270.
To evaluate the involvement of nitric oxide production on the endothelium-dependent relaxation in diabetes, we have measured vascular and endothelial function and nitric oxide concentration, and the expression level of...
Cardiac response to head-out water immersion in man

Choi JK, Park WK

  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):253-261.
Head-out water immersion induces marked increase in the cardiac stroke volume. The present study was undertaken to characterize the stroke volume change by analyzing the aortic blood flow and left ventricular systolic time...
Effect of lidocaine cntdot HCl on microviscosity of phosphatidylcholine model membrane.

Chung IK, Kim IS, Choi CH, Cho GJ, Kim JB, Son WS, Jang HO, Yun I

  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):243-251.
In order to provide a basis for studying the molecular mechanism of pharmacological action of local anesthetics and to develop a fluorescence spectroscopic method which can detect the microviscosity of native and model...
Expression of natriuretic peptide mRNAs in isoproterenol-induced cardiac hypertrophy in rats.

Kim SK, Kwon GY, Chang ES

  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):235-241.
We examined the expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) mRNAs upon isoproterenol (Iso)-induced cardiac hypertrophy in rats. Then, we tried to investigate the effects of sympatholytics to see...
Neurotensin enhances gastric motility in antral circular muscle strip of guinea-pig.

Koh TY, Kim SJ, Lee SJ, Kang TM, Yeoul JJ, Sim JH, So I, Kim KW

  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):227-234.
Many reports suggest that neurotensin (NT) in the gastrointestinal tract may play a possible role as a neurotransmitter, a circulating hormone, or a modulator of motor activity. NT exerts various actions in the...
Endotoxin-induced acute lung injury is mediated by PAF produced via remodelling of lyso PAF in the lungs

Lee YM, Kim T

  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):219-226.
In order to elucidate the role of platelet activating factor (PAF) in the acute lung injury induced by endotoxin (ETX), activities of phospholipase A2, lyso PAF acetyltransferase and oxidative stress by neutrophilic respiratory...
Tyrosine phosphorylation of paxillin may be involved in vascular smooth muscle contraction

Fang LH, Cho KS, Lee SJ, Ahn HY

  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):211-217.
Paxillin is a regulatory component of the complex of cytoskeletal proteins that link the actin cytoskeleton to the plasma membrane. However, the role of paxillin during smooth muscle contraction is unclear. We investigated...
Relationship between sarcoplasmic reticular calcium release and Na+-Ca2+ exchange in the rat myocardial contraction

Kim EG, Kim SJ, Ko CM

  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):197-210.
Suppressive role of Na+-Ca2+ exchange in myocardial tension generation was examined in the negative frequency-force relationship (FFR) of electric field stimulated left atria (LA) from postnatal developing rat heart and in the whole-cell...
Changes in the endothelin-1-induced contraction of aorta in streptozotocin-induced diabetic rats.

Cheong HJ, Kim EJ, Kim SJ, Lee SH, Rhim BY

  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):185-195.
Vascular diseases are significant complications of diabetes mellitus (DM), and the endothelial cells may play a pivotal role in the development of vascular disease in DM. Endothelin-1 (ET-1) released from endothelium is a...
Comparison of neurotoxicity induced by some glutathione depletors in mouse cortical cell cultures

Lee GW, Lee KS, Park SH, Bae CS, Kim JK

  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):177-183.
We examined the neurotoxic effects of 3 glutathione (GSH) depletors, buthionine sulfoximine (BSO), diethyl maleate (DEM) and phorone, under the presence of trolox, cycloheximide (CHX), pyrrolidine dithiocarbamate (PDTC) or MK-801 in primary mouse...
Developmental changes of gustatory neurons in nucleus of solitary tract in rats

Kim M, Kim W, Mistretta

  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):169-175.
To learn the developmental changes in intrinsic electrophysiological properties of the second order taste neurons, whole cell recordings from the developing nucleus of the solitary tract neurons were done in...

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