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10 results

Effect of sedative dose of propofol on neuronal damage after transient forebrain ischemia in Mongolian gerbils

Lee SR

  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):73-79.
This study investigated whether propofol, an intravenous, non-barbiturate anesthetic, could reduce brain damage following global forebrain ischemia. Transient global ischemia was induced in gerbils by occlusion of bilateral carotid arteries for 3 min....
Cadmium inhibition of renal endosomal acidification

Kim MS, Kim KR, Ahn DW, Park YS

  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):63-72.
Chronic exposure to cadmium (Cd) results in an inhibition of protein endocytosis in the renal proximal tubule, leading to proteinuria. In order to gain insight into the mechanism by which Cd impairs...
Effects of norepinephrine and neuropeptide Y on the contractility of small mesenteric artery from 2K1C and DOCA-salt hypertensive rats

Nam SC, Kang S, Kim W, Lee J

  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):55-61.
The present study was conducted to investigate the possible role of the sympathetic nervous system in two-kidney, one clip (2K1C) and deoxycorticosterone acetate (DOCA)-salt hypertension. 2K1C and DOCA-salt hypertension were made in Sprague-Dawley...
Transition metal induces apoptosis in MC3T3E1 osteoblast: Evidence of free radical release

Chae HJ, Chae SW, Kang JS, Yun DH, Bang BG, Kang MR, Kim HM, Kim HR

  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):47-54.
Transition metal ions including Se2+, Cd2+, Hg2+ or Mn2+ have been thought to disturb the bone metabolism directly. However, the mechanism for the bone lesion is unknown. In this study, we demonstrated...
Differential effects of local anesthetics on rate of rotational mobility between hydrocarbon interior and surface region of model membrane outer monolayer

Chung IK, Cha SK, Chung YZ, Kim BS, Choi CH, Cho GJ, Jang HO, Yun I

  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):41-46.
Using fluorescence polarization of 12-(9-anthroyloxy)stearic acid (12-AS) and 2-(9-anthroyloxy)stearic acid (2-AS), we evaluated the differential effects of local anesthetics on differential rotational rate between the surface (in carbon number 2 and its surroundings including...
The effect of NO donor on contraction, cytosolic Ca2+ level and ionic currents in guinea-pig ileal smooth muscle

Kwon SC, Park KY, Ahn DS, Lee YH, Kang BS

  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):33-40.
This study was designed to clarify the mechanism of the inhibitory action of a nitric oxide (NO) donor, 3-morpholino-sydnonimine (SIN-1), on contraction, cytosolic Ca2+ level ((Ca2+)i), and ionic currents in guinea-pig ileum. SIN-1...
Effect of propofol, an intravenous anesthetic agent, on KATP channels of pancreatic beta-cells in rats

Park EJ, Song DK, Cheun JK, Bae JI, Ho WK, Earm YE

  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):25-31.
ATP-sensitive potassium channels (KATP channels) play an important role in insulin secretion from pancreatic beta cells. We have investigated the effect of propofol on KATP channels in cultured single pancreatic beta cells of...
Responses of dorsal horn neurons to peripheral chemical stimulation in the spinal cord of anesthetized cats

Jung SJ, Park JM, Lee JH, Lee JH, Eun SY, Kim SJ, Lim WI, Cho SH, Kim J

  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):15-24.
Although nociceptive informations are thought to be processed via different neural mechanisms depending on the types of stimuli, sufficient data have not been accumulated yet. We performed a series of experiments to elucidate...
Effect of capsaicin on delayed rectifier K+ current in adult rat dorsal root ganglion neurons

Hahn J, Chung S, Bang H

  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):9-14.
K+ currents play multiple roles in the excitability of dorsal root ganglion (DRG) neurons. Influences on these currents change the shape of the action potential, its firing threshold and the resting membrane potential....
Roles of Ca2+ activated K+ conductances on spontaneous firing patterns of isolated rat medial vestibular nucleus neurons

Chun SW, Jun JW, Park BR

  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):1-8.
To investigate the contributions of intrinsic membrane properties to the spontaneous activity of medial vestibular nucleus (MVN) neurons, we assessed the effects of blocking large and small calcium-activated potassium channels by means of...

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