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The effect of indomethacin on the production of eicosanoids and edema during ischemia-reperfusion injury in skeletal muscle

Chung YJ, Sohn BK, Hyun KS, Yoo SH, Ryu HK, Kim HG

  • KMID: 1581031
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):525-530.
During reperfusion of skeletal muscle after ischemia, lipid mediators, mainly eicosanoids, are released and may have a role in the pathogenesis of reperfusion injury. To validate the role of eicosanoids in the ischemia-reperfusion...
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Myocardial protection by recombinant soluble P-selectin glycoprotein ligand-1: Suppression of neutrophil and platelet interaction following ischemia and reperfusion

Ham SS, Jang YY, Song JH, Lee HM, Kim KJ, Hong JS, Shin YK

  • KMID: 1581030
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):515-523.
Polymorphonuclear leukocytes (PMNs) play an important role in myocardial ischemia/reperfusion (MI/R) injury. Moreover, platelets are also important blood cells that can aggravate myocardial ischemic injury. This study was designed to test the effects...
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Role of Shc and phosphoinositide 3-kinase in heregulin-induced mitogenic signaling via ErbB3

Kim MS, Koland JG

  • KMID: 1581029
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):507-513.
ErbB3/HER3 is a cell surface receptor which belongs to the ErbB/HER subfamily of receptor protein tyrosine kinases. When expressed in NIH/3T3 cells, ErbB3 can form heterodimeric coreceptor with endogenous ErbB2. Among known intracellular...
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GLUT phosphorylation may be required to GLUT translocation mechanism

Hah JS

  • KMID: 1581028
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):497-506.
In this work, GLUTs phosphorylations by a downstream effector of PI3-kinase, PKC- zeta, were studied, and GLUT4 phosphorylation was compared with GLUT2 phosphorylation in relation to the translocation mechanism. Prior to phosphorylation experiment,...
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Comparative effects of PKB- alpha and PKC- zeta on the phosphorylation of GLUT4-containing vesicles in rat adipocytes

Hah JS

  • KMID: 1581027
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):487-496.
Insulin stimulates glucose transport in muscle and fat cells by promoting the translocation of glucose transporter (GLUT4) to the cell surface. Phosphatidylinositide 3-kinase (PI3-kinase) has been implicated in this process. However, the involvement...
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The effect of carbon monoxide on contraction, cytosolic Ca2+ level and ionic currents in guinea pig ileal smooth muscle

Kwon SC, Chung SS, Kim YS, Nam TS

  • KMID: 1581026
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):479-486.
The aim of this study was to clarify the mechanism of the inhibitory action of carbon monoxide (CO) on contraction, by measuring cytosolic Ca2+ level ((Ca2+)i) and ionic currents in guinea-pig ileum....
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Mechanism of L-NAME-resistant endothelium-dependent relaxation induced by acetylcholine in rabbit renal artery

Yeon DS, Ahn DS, Lee YH, Kwon SC

  • KMID: 1581025
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):471-477.
In the rabbit renal artery, acetylcholine (ACh, 1 nM ~ 10 micrometer) induced endothelium-dependent relaxation of arterial rings precontracted with norepinephrine (NE, 1 micrometer) in a dose-dependent manner. NG-nitro-L-arginine (L-NAME, 0.1 mM), an...
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Relaxant effect of 4-aminopyridine on the mesenteric artery of rat

Kim SH, Lee TI

  • KMID: 1581024
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):463-469.
It has been well known that 4-aminopyridine (4-AP) has an excitatory effect on vascular smooth muscle due to causing membrane depolarization by blocking K+-channel. However, we observed that 4-AP had an inhibitory effect...
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Zn2+ modulates the responses of rat dorsal horn neuron to C-fiber stimulation and excitatory amino acids

Ahn CH, Shin HK, Kim JH

  • KMID: 1581023
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):455-461.
Zinc contained in the neurons of central nervous system is activity-dependently released and then attenuates NMDA (N-methyl-D-aspartate)-induced neurotoxicity while augmenting non-NMDA-induced neurodegeneration. Zinc also has been reported to produce antinociceptive action on the inflammation-...
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Modulation of Ca2+ activated potassium channels by cGMP-dependent signal transduction mechanism in cerebral arterial smooth muscle cells of the rabbit

Han J, Kim N, Lee K, Kim E

  • KMID: 1581022
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):445-453.
The present investigation tested the hypothesis that the activation of protein kinase G (PKG) leads to a phosphorylation of Ca2+-activated potassium channel (KCa channel) and is involved in the activation of KCa channel...
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Effect of serotonin uptake inhibitors on serotonin metabolism in the hypothalamus of freely moving rats

Song YS, Yoon SN, Jung DS, Yoo SH, Ryu HK, Kim HG

  • KMID: 1581021
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):439-444.
Tricyclic antidepressant clomipramine or selective serotonin reuptake inhibitors (SSRIs) have been commonly used for the treatment of premature ejaculation. In the present study, we analyzed the concentrations of serotonin and 5-hydroxyindoleacetic acid (5-HIAA)...
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N-type calcium channels

Elmslie KS

  • KMID: 1581020
  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):427-437.
The early studies of cardiac and smooth muscle cells provided evidence for two different calcium channels, the L-type (also called high-voltage activated (HVA)) and the T-type (low-voltage activated (LVA)). These calcium channels provided...
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