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12 results

The effect of indomethacin on the production of eicosanoids and edema during ischemia-reperfusion injury in skeletal muscle

Chung YJ, Sohn BK, Hyun KS, Yoo SH, Ryu HK, Kim HG

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):525-530.
During reperfusion of skeletal muscle after ischemia, lipid mediators, mainly eicosanoids, are released and may have a role in the pathogenesis of reperfusion injury. To validate the role of eicosanoids in the ischemia-reperfusion...
Myocardial protection by recombinant soluble P-selectin glycoprotein ligand-1: Suppression of neutrophil and platelet interaction following ischemia and reperfusion

Ham SS, Jang YY, Song JH, Lee HM, Kim KJ, Hong JS, Shin YK

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):515-523.
Polymorphonuclear leukocytes (PMNs) play an important role in myocardial ischemia/reperfusion (MI/R) injury. Moreover, platelets are also important blood cells that can aggravate myocardial ischemic injury. This study was designed to test the effects...
Role of Shc and phosphoinositide 3-kinase in heregulin-induced mitogenic signaling via ErbB3

Kim MS, Koland JG

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):507-513.
ErbB3/HER3 is a cell surface receptor which belongs to the ErbB/HER subfamily of receptor protein tyrosine kinases. When expressed in NIH/3T3 cells, ErbB3 can form heterodimeric coreceptor with endogenous ErbB2. Among known intracellular...
GLUT phosphorylation may be required to GLUT translocation mechanism

Hah JS

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):497-506.
In this work, GLUTs phosphorylations by a downstream effector of PI3-kinase, PKC- zeta, were studied, and GLUT4 phosphorylation was compared with GLUT2 phosphorylation in relation to the translocation mechanism. Prior to phosphorylation experiment,...
Comparative effects of PKB- alpha and PKC- zeta on the phosphorylation of GLUT4-containing vesicles in rat adipocytes

Hah JS

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):487-496.
Insulin stimulates glucose transport in muscle and fat cells by promoting the translocation of glucose transporter (GLUT4) to the cell surface. Phosphatidylinositide 3-kinase (PI3-kinase) has been implicated in this process. However, the involvement...
The effect of carbon monoxide on contraction, cytosolic Ca2+ level and ionic currents in guinea pig ileal smooth muscle

Kwon SC, Chung SS, Kim YS, Nam TS

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):479-486.
The aim of this study was to clarify the mechanism of the inhibitory action of carbon monoxide (CO) on contraction, by measuring cytosolic Ca2+ level ((Ca2+)i) and ionic currents in guinea-pig ileum....
Mechanism of L-NAME-resistant endothelium-dependent relaxation induced by acetylcholine in rabbit renal artery

Yeon DS, Ahn DS, Lee YH, Kwon SC

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):471-477.
In the rabbit renal artery, acetylcholine (ACh, 1 nM ~ 10 micrometer) induced endothelium-dependent relaxation of arterial rings precontracted with norepinephrine (NE, 1 micrometer) in a dose-dependent manner. NG-nitro-L-arginine (L-NAME, 0.1 mM), an...
Relaxant effect of 4-aminopyridine on the mesenteric artery of rat

Kim SH, Lee TI

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):463-469.
It has been well known that 4-aminopyridine (4-AP) has an excitatory effect on vascular smooth muscle due to causing membrane depolarization by blocking K+-channel. However, we observed that 4-AP had an inhibitory effect...
Zn2+ modulates the responses of rat dorsal horn neuron to C-fiber stimulation and excitatory amino acids

Ahn CH, Shin HK, Kim JH

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):455-461.
Zinc contained in the neurons of central nervous system is activity-dependently released and then attenuates NMDA (N-methyl-D-aspartate)-induced neurotoxicity while augmenting non-NMDA-induced neurodegeneration. Zinc also has been reported to produce antinociceptive action on the inflammation-...
Modulation of Ca2+ activated potassium channels by cGMP-dependent signal transduction mechanism in cerebral arterial smooth muscle cells of the rabbit

Han J, Kim N, Lee K, Kim E

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):445-453.
The present investigation tested the hypothesis that the activation of protein kinase G (PKG) leads to a phosphorylation of Ca2+-activated potassium channel (KCa channel) and is involved in the activation of KCa channel...
Effect of serotonin uptake inhibitors on serotonin metabolism in the hypothalamus of freely moving rats

Song YS, Yoon SN, Jung DS, Yoo SH, Ryu HK, Kim HG

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):439-444.
Tricyclic antidepressant clomipramine or selective serotonin reuptake inhibitors (SSRIs) have been commonly used for the treatment of premature ejaculation. In the present study, we analyzed the concentrations of serotonin and 5-hydroxyindoleacetic acid (5-HIAA)...
N-type calcium channels

Elmslie KS

  • Korean J Physiol Pharmacol.
  • 2000 Dec;4(6):427-437.
The early studies of cardiac and smooth muscle cells provided evidence for two different calcium channels, the L-type (also called high-voltage activated (HVA)) and the T-type (low-voltage activated (LVA)). These calcium channels provided...

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