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Bile acid modulation of gastroinstinal smooth muscle contraction and ionic currents

Lee HK, Lee KH

  • Korean J Physiol Pharmacol.
  • 2000 Aug;4(4):333-338.
We have examined whether bile acids can affect the electrical and mechanical activities of circular smooth muscle of canine colon and ileum, using isometric tension measurement or patch clamp technique. It was found...
Inhibition of tumor necrosis factor-alpha mRNA expression by a limited series of tetrahydroisoquinolines in mouse peritoneal macrophages

Jung TH, Lee YS, Kang YJ, Lee BK, Ko YS, Seo HG, Chung SY, Lee DH, Yun-Choi H, Chang KC

  • Korean J Physiol Pharmacol.
  • 2000 Aug;4(4):325-331.
Tumor necrosis factor-alpha (TNF-alpha) plays important roles in inflammatory responses. Some of tetrahydroisoquinoline (THI) compounds exhibited to inhibit iNOS expression in animal studies and RAW 264.7 cells, but the action of THI on...
Effect of heat shock protein 72 on the generation of reperfusion arrhythmias

Chang MJ, Na HS, Nam HJ, Pyun KS, Hong SK

  • Korean J Physiol Pharmacol.
  • 2000 Aug;4(4):319-324.
The causal relationship between heat shock protein (HSP) and second window of cardioprotective effect is still undetermined. In the present study, we assessed whether HSP-producing substances, amphetamine and ketamine, afforded protection against reperfusion-induced...
Asymmetrical distribution of P2Y nucleotide receptors in rabbit inner medullary collecting duct cells

Woo JS, Jung JS, Kim YK

  • Korean J Physiol Pharmacol.
  • 2000 Aug;4(4):311-318.
We cultured the rabbit inner medullary collecting duct (IMCD) cells as monolayers on collagen-coated membrane filters, and investigated distribution of the P2Y receptors by analyzing nucleotide-induced short circuit current (Isc) responses. Exposure to...
Effects of prostaglandin F2alpha on membrane potentials and K+ currents in rabbit middle cerebral arterial cells

Kim N, Han J, Kim WG, Kim E

  • Korean J Physiol Pharmacol.
  • 2000 Aug;4(4):301-309.
The purpose of our investigation was to examine the effects of prostaglandin F2alpha (PGF2alpha) on membrane potentials, Ca2+-activated K+ (KCa) channels, and delayed rectifier K+ (KV) channels using the patch-clamp technique in single...
Changes of the level of G protein alpha-subunit mRNA by withdrawal from morphine and butorphanol

Oh S

  • Korean J Physiol Pharmacol.
  • 2000 Aug;4(4):291-299.
Morphine or butorphanol was continuously infused into cerebroventricle (i.c.v.) with the rate of 26 nmol/microliter/h for 3 days, and the withdrawal from opioid was rendered 7 hrs after the stopping of infusion....
Effect of atrial natriuretic peptide on the proliferation and activity of osteoblastic cells

Lee JR, Ko SY, Kim JK, Kim SW

  • Korean J Physiol Pharmacol.
  • 2000 Aug;4(4):283-289.
Natriuretic peptides comprise a family of three structurally related peptides; atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). The present study was performed to investigate the effect of...
Effects of cholecystokinin octapeptide on neuronal activities in the rat nucleus tractus solitarius

Rhim H, Park CW

  • Korean J Physiol Pharmacol.
  • 2000 Aug;4(4):275-281.
Cholecystokinin (CCK) is a gastrointestinal hormone which plays an important role in satiety and gastric motility. It is also widely distributed throughout the central nervous system, where it appears to be involved in...
ATP-sensitive K+ channels: Structure, function, and physiological roles

Seino S

  • Korean J Physiol Pharmacol.
  • 2000 Aug;4(4):271-274.
No abstract available.

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