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14 results

Role of Ca2+ in the stimulation of glucose transport by insulin in adipocytes

Chang SH, Jang YJ, Park KK, Kim GS, Ryu HJ, Park CS

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):357-364.
We investigated the role of Ca2+ and protein kinases/phosphatases in the stimulatory effect of insulin on glucose transport. In isolated rat adipocytes, the simple omission of CaCl2 from the incubation medium significantly reduced,...
Altered Calcium Current of the Vascular Smooth Muscle in Renal Hypertension

Nam SC, Jeong HJ, Kim W, Lee J

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):351-356.
The present study was aimed at investigating whether the calcium current in the vascular smooth muscle (VSM) cells is altered in renal hypertension. Two-kidney, one clip (2K1C) and deoxycorticosterone acetate (DOCA)-salt hypertension were...
Mechanism of pituitary adenylate cyclase-activating polypeptide-induced inhibition on catecholamine secretion evoked by cholinergic stimulation and membrane depolarization in the rat adrenal gland

Lim DY, Kang JW, Kim YJ

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):339-350.
The present study was attempted to examine the effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on catecholamine (CA) secretion evoked by cholinergic stimulation, membrane depolarization and calcium mobilization from the isolated perfused rat...
Thyroid hormone-induced alterations of ryanodine and dihydropyridine receptor protein expression in rat hear

Kim HW, Park M, Lee EH, Cho HJ, Lee HR

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):329-337.
Thyroid hormone-induced cellular dysfunctions may be associated with changes in the intracellular Ca2+ concentration. The ryanodine receptor, a Ca2+ release channel of the SR, is responsible for the rapid release of Ca2+ that...
Characteristics of hypoxic pulmonary vasoconstriction of the rat: Study by the vessel size and location in the lung

Lee SJ, Kim KW

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):321-328.
Pulmonary blood vessels with diameters of 200 ~ 400 micrometer produce considerably more force in response to vasoconstrictor drugs than those which are either smaller or larger. We have therefore investigated whether or...
Tissue-specific regulation of angiotensinogen and angiotensin II receptor gene expression in deoxycorticosterone acetate-salt hypertensive rats

Lee JU, An MR

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):315-320.
Molecular regulation of the renin-angiotensin system (RAS) was investigated in deoxycorticosterone acetate (DOCA)-salt hypertension. The expression of renin, angiotensinogen and angiotensin II receptor genes in the kidney and liver was determined by Northern...
Effects of Cl- channel blockers on the cardiac ATP-sensitive K+ channel

Kwak YG

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):305-313.
To explore whether Cl- channel blockers interact with the ATP-sensitive K+ (KATP) channel, I have examined the effect of two common Cl- channel blockers on the KATP channel activity in isolated rat...
Opening of ATP-sensitive K+ channel by pinacidil requires serine/threonine phosphorylation in rat ventricular myocytes

Kwak YG, Chae SW

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):293-303.
The influences of specific protein phosphatase and protein kinase inhibitors on the ATP-sensitive K+ (KATP) channel-opening effect of pinacidil were investigated in single rat ventricular myocytes using patch clamp technique. In cell-attached patches,...
Selective cytotoxicity of a novel platinum (II) coordination complex on human gastric cancer cell lines and normal kidney cells

Jung JC, Kim YK, Yim SV, Park SJ, Chung JH, Chang SG, Lee KT, Rho YS

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):283-291.
We have synthesized novel platinum (II) coordination complex containing cis-1,2-diaminocyclohexane (DACH) as a carrier ligand and 1,2-bis(diphenylphosphino)ethane (DPPE) as leaving group. Furthermore, nitrate was added to improve the water-solubility. A new series of (Pt(cis-DACH)(DPPE))...
Involvement of Spontaneously Formed Cyclic Nucleotides in Cat Gastric Muscle Relaxation

Sim SS, Baek HJ, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):275-282.
Muscle strips and muscle cells from cat stomach were used to investigate whether spontaneously formed cyclic nucleotides were involved in the inhibition of gastric smooth muscle contraction. A phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (IBMX), increased the...
Effect of the inhibition of phospholipase A2 in generation of free radicals in intestinal ischemia/reperfusion induced acute lung injury

Lee YM, Park YY, Kim T, Cho HG, Lee YJ, Repine JE

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):263-273.
The role of phospholipase A2 (PLA2) in acute lung leak induced by intestinal ischemia was investigated in association with neutrophilic respiratory burst. To induce lung leak, we generated intestinal ischemia for 60 min...
Effects of carnosine and related compounds on monosaccharide autoxidation and H2O2 formation

Lee BJ, Kang KS, Nam SY, Park JH, Lee YS, Yun YW, Cho MH

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):251-261.
The effects of carnosine and related compounds (CRCs) including anserine, homocarnosine, histidine, and beta-alanine on monosaccharide autoxidation and H2O2 formation were investigated. The incubation of CRCs with D-glucose, D-glucosamine, and D, L-glyceraldehyde at 37degreeC...
Electroencephalographic effects of chlorpromazine in rats

Yun JE, Lee MG

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):245-250.
The effects of an antipsychotic, chlorpromazine, on the electroencephalogram (EEG) were observed while rats were awake but immobile. The time course and the dose-dependency of the EEG changes were examined. The method of...
Magnesium suppresses the responses of dorsal horn cell to noxious stimuli in the rat

Shin HK, Kim JH, Kim KS

  • Korean J Physiol Pharmacol.
  • 1999 Jun;3(3):237-244.
Magnesium ion is known to selectively block the N-methyl-D-aspartate (NMDA)-induced responses and to have anticonvulsive action, neuroprotective effect and antinociceptive action in the behavioral test. In this study, we investigated the effect of...

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