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13 results

The effects of sera from amyotrophic lateral sclerosis patients on neuromuscular transmission and calcium channels in mice

Yan HD, Kim J, Jung SJ, Kim J

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):101-117.
Amyotrophic lateral sclerosis (ALS) is a degenerative neuromuscular disease of unknown etiology in which the upper and lower motor neurons are progressively destroyed. Recent evidences support the role of autoimmune mechanisms in the...
Role of phospholipase A2 in hypoxia-induced renal cell injury

Choi WR, Ko SH, Cho SI, Woo JS, Jung JS, Lee SH, Kim YK

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):93-100.
The present study was designed to assess the roles of PLA2 activation and arachidonic acid (AA) metabolites in hypoxia-induced renal cell injury. Hypoxia increased LDH release in a dose-dependent manner in rabbit renal...
The roles of arachidonic acid and calcium in the angiotensin II-induced inhibition of Na+ uptake in renal proximal tubule cells

Park SH, Koh HJ, Lee YH, Son CH, Park MK, Lee YJ, Han HJ

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):83-91.
Angiotensin II (ANG II) has a biphasic effect on Na+ transport in proximal tubule: low doses of ANG II increase the Na+ transport, whereas high doses of ANG II inhibit it. However,...
Activation of SAPK and increase in Bak levels during ceramide and indomethacin-induced apoptosis in HT29 cells

Kim JH, Oh SO, Jun SS, Jung JS, Woo JS, Kim YK, Lee SH

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):75-82.
It has been reported that activation of sphingomyelin pathway and nonsteroidal anti-inflammatory drugs (NSAIDS) inhibit the promotion of colon carcinoma. Ceramide, a metabolite of sphingomyelin, and indomethacin were shown to induce apoptosis in...
Systemic injection of lidocaine induce expression of c-fos mRNA and protein in adult rat brain

Chae HJ, Kang JS, Cho SB, Jin BG, Won SJ, Gwan BJ, Kim HR

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):69-74.
Both direct and indirect environmental stress to brain were increase the expression of transcription factor c-fos in various populations of neurons. In this study, we examined whether the intraperitoneal injections of lidocaine at...
Regulation of magnesium release by cAMP during chemical hypoxia in the rat heart and isolated ventricular myocytes

Kim JS, Scarpa A

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):59-68.
Chemically induced hypoxia has been shown to induce a depletion of ATP. Since intracellular free Mg2+ ((Mg2+)i) appears to be tightly regulated following cellular energy depletion, we hypothesized that the increase in (Mg2+)i...
Role of Adenosine in the Activation of Myocardial Catalase Induced by Brief Regional Ischemia

Kim YH, Kim CH, Kim GT, Choi H, Park JW, Kim MS

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):53-57.
The activities of myocardial antioxidant enzymes are known to increase in the hearts preconditioned with the brief episodes of ischemia. This study was undertaken to elucidate the possible involvement of adenosine in the...
Gradual reperfusion lowers the incidence of reperfusion-induced ventricular fibrillation in a cat model of regional ischemia

Kim YH, Na HS, Nam HJ, Hur GY, Lee SW, Park SS, Hong SK

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):47-52.
Blood flow restoration to ischemic zone of the heart is essential to salvage of ischemic tissue. However, there is a large body of evidence documenting that the reperfusion can induce reperfusion injury...
Calcium modulates excitatory amino acid (EAA)- and substance P-induced rat dorsal horn cell responses

Shin HK, Kang SH, Chung ID, Kim KS

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):35-45.
Excitatory amino acid (EAA) and substance P (SP) have been known to be primary candidates for nociceptive neurotransmitter in the spinal cord, and calcium ions are implicated in processing of the sensory informations...
Cholinergic activity related to cardiovascular regulation in rostral ventrolateral medulla of spontaneously hypertensive rats

Lee SY, Lee SB

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):29-34.
The hyperactivity of cholinergic system in the RVLM of spontaneously hypertensive rats (SHR) may contribute to the sustained elevation of blood pressure. However, the hyperactivity mechanisms of cholinergic system are controversial. Thus, to...
The mechanism of t-butylhydroperoxide-induced apoptosis in IMR-32 human neuroblastoma cells

Kim JA, Lee YS, Huh K

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):19-28.
Apoptosis has been implicated in the pathophysiological mechanisms of various neurodegenerative diseases. In a variety of cell types, oxidative stress has been demonstrated to play an important role in the apoptotic cell death....
Role of protein kinases on NF- kappaB activation and cell death in bovine cerebral endothelial cells

Ahn YS, Kim CH, Kim JH

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):11-18.
Nuclear factor kappaB (NF- kappaB) activation is modulated by various protein kinases. Activation of NF- kappaB is known to be important in the regulation of cell viability. The present study investigated the effect...
Mechanism of membrane hyperpolarization by extracellular K+ in resistance-sized cerebral arterial muscle cell of rabbit

Kim SH, Choi KM, Kim HS, Jeon BH, Chang SJ

  • Korean J Physiol Pharmacol.
  • 1999 Feb;3(1):1-10.
We sought to find out the mechanism of vascular relaxation by extracellular K+ concentration ((K+)o) in the cerebral resistant arteriole from rabbit. Single cells were isolated from the cerebral resistant arteriole, and using...

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