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Enhancement of cyclosporine-induced oxidative damage of kidney mitochondria by iron

Jang YY, Han ES, Lee CS, Kim YK, Song JH, Shin YK

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):631-640.
The present study investigated the stimulatory effects of iron (or ascorbate) on cyclosporine-induced kidney mitochondrial damage. Damaging effect of 50 muM cyclosporine plus 20 muM Fe2+ on mitochondrial lipids and proteins of rat...
Depression of L-type Ca2+ and transient outward K+ currents in endotoxin-treated rat cardiac myocytes

Park KS, Lee BS, Kong ID, Lee JW

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):623-630.
Decreased cardiac contractility occurs in endotoxicosis, but little is known about the ionic mechanism responsible for myocardial dysfunction. In this study, we examined the changes in Ca2+ and K+ currents in cardiac myocytes...
Effects of bradykinin on intracellular calcium transients in cardiac myocytes

Park CO, Kim YM, Han JH, Allen DG, Hong SG

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):615-621.
In spite many evidences has supported the cardioprotective effect of bradykinin, its direct effects at the cell level are still under question. We investigated the both effects of bradykinin (BK) on Ca2+-related ionic...
Spectral analysis of heart rate variability during passive standing after ethanol ingestion

Kim HJ, Han CD, Yang EK, Lee WJ

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):605-613.
The purpose of the present study was to evaluate cardiovascular regulation during passive standing (PS) after ethanol ingestion by spectral analysis of heart rate variability (HRV) in flushed and nonflushed subjects. Of 24...
The transfection of caldesmon DNA into primary cultured rat aortic vascular smooth muscle

Choi W, Ahn HY

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):597-603.
Caldesmon (CaD), one of microfilament-associated proteins, plays a key role in microfilament assembly in mitosis. We have investigated the effects of overexpression of the high molecular weight isoform of CaD (h-CaD) on the...
Effects of calcium channel blockers on porcine cardiac and coronary arterial function in ischemia-reperfusion

Baik YH, Kook H, Park SH, Jeong SJ, Lim DY

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):587-595.
This study was designed to investigate effects of calcium antagonists on endothelial and neuronal dysfunction of right coronary artery (RCA) induced by ischemia- reperfusion in anesthetized, open-chest pigs. After reperfusion, pigs were sacrificed...
Effect of C1 esterase inhibitor on the cardiac dysfunction following ischemia and reperfusion in the isolated perfused rat heart

Lee GY, Shin YK, Jang YY, Song JH, Kim DJ

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):579-586.
Complement-mediated neutrophil activation has been hypothesized to be an important mechanism of reperfusion injury. It has been proposed that C1 esterase inhibitor (C1 INH) may prevent the complement-dependent activation of polymorphonuclear leukocytes (PMNs)...
Effects of protein kinase C modulation on hepatic hemodynamics and glucoregulation

Lee JW, Kong ID, Park KS, Chung HS, Filkins JP

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):571-578.
This study evaluated the effects of PKC activation using phorbol 12-myristate 13-acetate (PMA) and PKC inhibition using the isoquinoline sulfomide derivative H-7 on hemodynamics and glucoregulation in the isolated perfused rat liver. Livers...
Glycochenodeoxycholic acid induces cell death in primary cultured rat hepatocyte: Apoptosis and necrosis

Chu SH, Park WM, Lee KE, Pae YS

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):565-570.
Intracellular accumulation of bile acids in the hepatocytes during cholestasis is thought to be pathogenic in cholestatic liver injury. Due to the detergent-like effect of the hydrophobic bile acids, hepatocellular injury has been...
Hemorrhage- and restraint-induced analgesia in male and female conscious rats

Oh SY, Han HS, Ahn DK, Park JS

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):555-563.
It is well known that stress induces analgesia. This study was designed to demonstrate the stress-induced analgesia by employing hemorrhage and restraint and to investigate its mechanism and sex difference. The degree of...
Role of K+ channels to resting membrane potential of rabbit middle cerebral arterial smooth muscle cells

Kim N, Han J, Kim E, Kim YH, Sim JH, Kim SC

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):547-554.
The aim of the present study is to investigate the contribution of Ca2+-activated K+ (KCa) channels and delayed rectifier K+ (KV) channels to the resting membrane potential (RMP) in rabbit middle cerebral arterial...
Effect of cytokines and bFGF on the osteoclast differentiation induced by 1 alpha,25-(OH)2D3 in primary murine bone marrow cultures

Chae HJ, Kang JS, Bang BG, Cho SB, Han JI, Choi JY, Kim HM, Chae SW, Kim HR

  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):539-546.
Bone is a complex tissue in which resorption and formation continue throughout life. The bone tissue contains various types of cells, of which the bone forming osteoblasts and bone resorbing osteoclasts are mainly...

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