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The enhancement of endotoxin-induced nitric oxide production by elevation of glucose concentration in macrophage

Woo HG, Jung YS, Baik EJ, Moon CH, Lee SH

  • Korean J Physiol Pharmacol.
  • 1999 Aug;3(4):447-454.
The production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS) are known to be modulated by a variety of factors. Recent study showed that endotoxin-induced NO synthesis...
Effect of imipramine on calcium utilization of single cells isolated from canine detruso

Shim HS, Choi HC, Jeong YS, Kim JH, Lee KY, Sohn UD, Ha JH, Kim WJ

  • Korean J Physiol Pharmacol.
  • 1999 Aug;3(4):439-445.
This study is to investigate the mechanism of inhibitory effect of imipramine on the calcium utilization in single cells isolated from canine detrusor. 2 mm thick smooth muscle chops were incubated in...
Effects of acarbose on the expression of obese and neuropeptide Y (NPY) genes in mice on high-carbohydrate diet

Kim J, Chung S

  • Korean J Physiol Pharmacol.
  • 1999 Aug;3(4):433-438.
Two components of the neuroendocrine-hormonal response to long-term treatment of acarbose, adipose tissue-derived leptin and central neuropeptide Y (NPY), were investigated in the ICR mice on a high-carbohydrate diet. Acarbose, administered 5 or...
Distribution, content and molecular heterogeneity of gastrin-releasing peptide in rat pancreas

Park HS, Park HJ

  • Korean J Physiol Pharmacol.
  • 1999 Aug;3(4):427-432.
Although importance of intrapancreatic neurons containing gastrin-releasing peptide (GRP) in control of exocrine secretion has been raised, the nature of GRP in the pancreas is unclear Thus, the present study was undertaken to...
Different mechanisms for K+-induced relaxation in various arteries

Suh SH, Park SJ, Choi JY, Sim JH, Kim YC, Kim KW

  • Korean J Physiol Pharmacol.
  • 1999 Aug;3(4):415-425.
(K+)o can be increased under a variety of conditions including subarachnoid hemorrhage. The increase of (K+)o in the range of 5 ~ 15 mM may affect tensions of blood vessels and cause...
PAF contributes to intestinal ischemia/reperfusion-induced acute lung injury through neutrophilic oxidative stress

Lee YM, Park YY

  • Korean J Physiol Pharmacol.
  • 1999 Aug;3(4):405-414.
The role of platelet-activating factor (PAF) was investigated in intestinal ischemia/reperfusion (I/R) induced acute lung injury associated with oxidative stress. To induce acute lung injury following intestinal I/R, superior mesenteric arteries were clamped...
Reoxygenation stimulates EDRF(s) release from endothelial cells of rabbit aorta

Suh SH, Han JJ, Park SJ, Choi JY, Sim JH, Kim YC, Kim KW

  • Korean J Physiol Pharmacol.
  • 1999 Aug;3(4):393-404.
We have reported that hypoxia stimulates EDRF(s) release from endothelial cells and the release may be augmented by previous hypoxia. As a mechanism, it was hypothesized that reoxygenation can stimulate EDRF(s) release from...
Influence of mild hypothermia on clonidine-induced cardiovascular responses in the pentobarbital-anesthetized rat

Kim EJ, Kim SY, Lee SB

  • Korean J Physiol Pharmacol.
  • 1999 Aug;3(4):383-391.
This study was carried out to determine whether the effects of an alpha2-adrenoceptor agonist, clonidine, on mean arterial pressure (MAP) and heart rate (HR) are influenced by mild hypothermia. Experiments were performed in...
Enhanced expression of inducible nitric oxide synthase may be responsible for altered vascular reactivity in streptozotocin-induced diabetic rats

Jang JK, Kang YJ, Seo HG, Seo SJ, Chang KC

  • Korean J Physiol Pharmacol.
  • 1999 Aug;3(4):375-382.
Growing evidence indicates that enhanced generation or actions of nitric oxide (NO) are implicated in the pathogenesis of hypertension in spontaneously hypertensive rats and diabetic nephropathy in streptozotocin (STZ)-induced diabetic rats. We investigated...
The role of somatostatin in nociceptive processing of the spinal cord in anesthetized cats

Jung SJ, Park JM, Lee JH, Lee J, Kim SJ, Jun K

  • Korean J Physiol Pharmacol.
  • 1999 Aug;3(4):365-373.
Somatostatin (SOM) is one of the major neuropeptides in dorsal root ganglion cells, but its role in spinal nociceptive process has not been well known. In present study we aimed to investigate...

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