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In vitro cytotoxicity of novel platinum(II) coordination complexes containing diaminocyclohexane and diphenylphosphines

Jung JC, Kim YK, Park SJ, Chung JH, Chang SG, Lee KT, Baek MS, Park JJ, Rho YS

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):395-401.
We have synthesized new platinum(H) analogs containing 1,2-diaminocyclohexane (dach) as a carrier ligand, 1,3-bis(diphenylphosphino) propane (DPPP) /1,2-bis(diphenylphosphino)ethane (DPPE) as a leaving group and nitrates to improve solubility. In the present study, the cytotoxicity of (Pt(trans-l-dach)(DPPP))cntdot2NO3...
Molecular pharmacological interaction of phenylbutazone to human neutrophil elastase

Kang K

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):385-393.
Human neutrophil elastase (HNElastase, EC 3.4.21.37), a causative factor of inflammatory diseases, was purified by Ultrogel AcA54 gel filtration and CM-Sephadex ion exchange chromatography. HNElastase was inhibited by phenylbutazone in a concentration dependent...
Tetrachloroauric acide depresses the activation processes of phagocytic cells

Lee CS

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):377-384.
Gold compounds depress phagocytic cell responses, including chemotaxis, and respiratory burst. However, the effects of gold compounds on the function of phagocytic cells are variable according to the preparation of medicine. In this...
Hydroxyl radical-mediated commitment of HL-60 cells to differentiation: Modulation of differentiation process by phosphodiesterase inhibitors

Cho JY, Ahn WS, Cha SH, Lee KH, Kim WI, Chung MH

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):369-376.
Ms report shows that hydroxyl radical, generated by a Fenton reaction involving adenosine 5'-diphosphate/Fe2+ complex (5-15 micrometer) and H2O2 (2 micrometer), induced differentiation of HL-60 cells in a dose- and time-dependent manner. This...
Effects of prostaglandin E2 on the spontaneous contractions and electrical activities of the antral circular muscle in guinea-pig stomach

Kim JY, Kim SJ, Kang TM, Lee SJ, Jun JY, So I, Kim KW

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):361-368.
The spontaneous contractions of gastric smooth muscles are regulated by slow waves, which are modulated by both nervous system and humoral agents. This study was designed to examine the effects of Prostaglandin E2...
Inhibitory effect of caffeine on carbachol-induced nonselective cationic current in guinea-pig gastric myocytes

Kim SJ, Min KW, Kim YC, Lee SJ, So I, Kim KW

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):353-359.
In gastrointestinal smooth muscle, muscarinic stimulation by carbachol (CCh) activates nonselective cation channel current (ICCh) which is facilitated by intracellular (Ca2+) increase. Caffeine is widely used in experiments to mobilize Ca2+ from intracellular...
Nitric oxide impairs the recovery from hemorrhagic hypotension in conscious rats

Park YY, Lee YM

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):345-351.
The role of nitric oxide (NO) in the hemorrhagic hypotension was examined using a NO synthase inhibitor, Nomega-nitro-L-arginine methyl ester (L-NAME), in conscious rats, The rats were bled at a constant rate (2...
Cardioprotective effects of low dose bacterial lipopolysaccharide may not be directly associated with prostacyclin production

Moon CH, Kim JY, Lee SH, Baik EJ

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):331-343.
Sublethal dose of bacterial lipopolysaccharide (LPS) would induce protection against cardiac ischemic/ reperfusion (I/R) injury. This study examines the following areas: 1) the temporal induction of the cardioprotection produced by LPS; and 2)...
Comparison of inodilator effect of higenamine, YS49, YS51, tetra-hydroisoquinoline analogs, and dobutamine in the rat

Chong WS, Lee YS, Kang YJ, Lee DH, Ryu JC, Yun-Choi H, Chang KC

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):323-330.
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines. Many of them, especially with 6,7-disubstitution, demonstrate a relatively high affinity for catecholamines. Present study examines the pharmacological action of limited series...
Characteristics of Ca2+ stores in rabbit cerebral artery myocytes

Kim SJ, Kim JK, So I, Suh SH, Lee SJ, Kim KW

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):313-322.
In a myocyte freshly isolated from rabbit cerebral artery, the characteristics of Ca2+ release by histamine or caffeine were studied by microspectrofluorimetry using a Ca2+-binding fluorescent dye, fura-2. Histamine (5 micrometer) or caffeine...
Intracisternal antidepressants suppressed the nociceptive jaw opening reflex in freely moving rats

Ahn DK, Kim YS

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):307-312.
This study was performed to investigate the mechanism of central analgesic effects of antidepressants. Thirty four male rats were anesthetized with pentobarbital sodium (40 mg/kg, ip). A stainless steel guide cannula and a...
Characteristic intracellular response to lidocaine and MK-801 of hippocampal neurons: An in vivo intracellular neuron recording study

Choi BJ, Cho JH

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):297-305.
This study used in vivo intracellular recording in rat hippocampus to evaluate the effect of lidocaine and MK-801 on the membrane properties and the synaptic responses of individual neurons to electrical stimulation of...
Influence of the central benzodiazepinergic system on peripheral cardiovascular regulation

Koh JT, Ju JM, Shin DH, Cho HH, Choi BK, Kim JH

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):287-295.
Diazepam is known to have cardiovascular depressive effects through a combined action on benzodiazepinergic receptor and the GABA receptor-chloride ion channel complex. Moreover, it is known that barbiturates also have some cardiovascular regulatory...
Effects of glutamate receptor antagonists and protein synthesis inhibitor on delayed neuronal death induced by transient global ischemia in rat brain

Ko JS, Bae CS, Kim JK

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):279-286.
It has been well documented that transient forebrain global ischemia causes selective neuronal degeneration in hippocampal CA1 pyramidal neurons with a delay of a few days. The mechanism of this delayed hippocampal CA1...
Aquaporins in the kidney

Sasaki S

  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):271-277.
No abstract available.

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