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The inhibitory mechanism of aloe glycoprotein (NY945) on the mediator release in the guinea pig lung mast cell activated with antigen-antibody complexes

Ro JY, Lee BC, Chung MH, Lee SK, Sung CK, Kim KH, Park YI

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):119-131.
It has been reported that the glycoprotein extracted from Aloe has strong anti-inflammatory response. However, there has been no research report yet about the effect of Aloe on allergic hypersensitivity reactivity. By using...
Depression of Ca2+ influx in complement C5a-stimulated neutrophils by calmodulin inhibitors

Ham DS, Kim HH, Han ES, Lee CS

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):109-117.
Role of Ca2+/calmodulin complex in intracellular Ca2+ mobilization in neutrophils has not been clearly elucidated. In this study, effects of chlorpromazine, trifluoperazine and imipramine on the intracellular Ca2+ mobilization, including Ca2+ influx, in...
Discrepancy between in vitro and in vivo effect of Galphas gene mutation on the mRNA expression of TRH receptor

Park S, Yang I, Yim S, Chung J, Jung J, Ko K, Kim Y, Choi Y

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):101-108.
We investigated the effect of alpha-subunit of the stimulatory GTP-binding protein (Galphas) gene mutation on the expression of the thyrotropin-releasing hormone (TRH) receptor (TRH-R) gene in GH3 cells and in growth hormone (GH)-secreting...
The characterization of the increase of membrane conductance after depolarization in single rat adrenal chromaffin cells

Lim W, Kim SJ, Kim J

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):95-100.
The conductance change evoked by step depolarization was studied in primarily cultured rat adrenal chromaffin cells using patch-clamp and capacitance measurement techniques. When we applied a depolarizing pulse to a chromaffin cell, the...
ATP-sensitive K+ currents in gastric myocytes isolated from guinea-pig

Jun JY, Yeum CH, Yun PJ, Park JS, Kim SJ, So I, Kim KW

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):85-93.
ATP-sensitive K+ channels (KATP) were not identified in gastric smooth muscle cells. However, in tension recording of intact gastric circular muscle, lemakalim of KATP channels opener in other tissues suppressed mechanical contractions and...
Prostaglandin in regulations of renal blood flow during partial ureteral obstruction in dogs

Song HB, Yang HM, Min YG

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):77-84.
Ureteral obstruction causes increase in renal blood flow (RBF) and partial impairment of the autoregulation of RBF. Although increased renal prostaglandin production is responsible for the former, it is not clear whether or...
Effect of cisplatin on Na+/H+ antiport in the OK renal epithelial cell line

Kim JY, Park YS

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):69-76.
Cis-diamminedichloroplatinum II (cisplatin), an effective antitumor agent, induces acute renal failure by unknown mechanisms. To investigate direct toxic effects of cisplatin in the renal proximal tubular transport system, OK cell line was selected...
Changes in cytosolic Ca2+ but not in cGMP contents may be more important to nitric oxide-mediated relaxation in depolarized vascular smooth muscle

Lee HS, Chang KC

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):63-68.
Nitric oxide (NO)-mediated relaxation in vascular smooth muscle involves not only activation of guanylate cyclase but also hyperpolarization of the membrane. It has been shown that depolarization decreases the (Ca2+) sensitivity of myosin...
Effects of alpha-, beta-adrenergic, and calcium channel blockers on renin- angiotensin system in perfused rat heart

Park CG

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):55-62.
alpha-,beta-Adrenergics, and calcium channels were known to be related to inducing cardiac hypertrophy. Recently, it was reported that the cardiac renin-angiotensin system (RAS) was an important factor in ventricular hypertrophy. The present study...
Effects of histamine H|2-receptor stimulation on Mg2+ efflux in perfused guinea pig heart

Kang HS, Chang SE, Kang CW, Chae SW, Kim JS

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):49-54.
Mg2+ is an important regulator of many cardiac functions. However, regulation of intracellular Mg2+ activity in the heart is not well characterized. To assess the effect of histamine H2-receptor stimulation on intracellular Mg2+...
Differential effect of homocysteic acid and cysteic acid on changes of inositol phosphates and (Ca2+)i in rat cerebellar granule cells

Kim WK, Pae YS

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):41-48.
The present study was undertaken to characterize homocysteic acid (HCA)-and cysteic acid (CA)mediated formation of inositol phosphates (InsP) in primary culture of rat cerebellar granule cells. HCA and CA stimulated InsP formation in...
Characteristics of A|1 and A|2 adenosine receptors upon the acetylcholine release in the rat hippocampus

Kim DK, Lee YS, Choi BK

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):31-39.
As it has been reported that the depolarization induced acetylcholine (ACh) release is modulated by activation of presynaptic A1 adenosine heteroreceptor and various lines of evidence suggest the A2 adenosine receptor is present...
Chemical coupling between horizontal cells in the catfish retina

Lee SJ, Jung CS, Bai SH

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):21-30.
The effects of GABA and glutamate on the horizontal cells were explored by an intracellular recording method to discern the mechanisms of receptive field formation by chemical coupling in the catfish outer retina....
Sensory inputs to upper cervical spinal neurons projecting to midbrain in cats

Kim JH, Jeong HS, Park JS, Kim JK, Park SH

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):9-19.
The present study was primarily carried out to characterize the properties of the spinomesencephalic tract (SMT) neurons that project from the upper cervical spinal segments to the midbrain. It was also investigated whether...
Ca2+-dependent exocytosis in endocine, exocrine, and nonsecretory cells

Haruo K

  • Korean J Physiol Pharmacol.
  • 1998 Feb;2(1):1-7.
Exocytosis in various secretory cells is regulated by Ca2+ signaling. In this minireview, I will introduce our recent approach, which we have termed comparative biology of exocytosis, to the study...

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