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15 results

Simultaneous HPLC analysis of arachidonic acid metabolites in biological samples with simple solid phase extraction

Kim HG, Huh YN, Park KS

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):779-786.
A reversed-phase high-performance liquid chromatography (RP-HPLC) has been developed to analyze the metabolites of arachidonic acid based on the specificities of ultraviolet absorption of these various metabolites and is sensitive to the nanogram...
Effects of angiotensin converting enzyme inhibition on gene expression of the renin-angiotensin system in rats

Lee YR, Lee MY, Kim WJ, Lee WJ

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):771-778.
To investigate interaction of angiotensin converting enzyme (ACE) inhibitor with local tissue renin-angiotensin system (RAS), changes in gene expression of the RAS components in various tissues in response to chronic administration of an...
Effect of endothelin-1 on proliferation and differentiation of rat tracheal epithelial cells

Kim CS, Oh SO, Woo JS, Jung JS, Kim YK, Lee SH

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):763-770.
A number of substances involved in the proliferation and differentiation of the tracheobronchial epithelium have been identified. The defects in the control of the proliferation and differentiation of tracheobronchial epithelial cells appear to constitute...
Involvement of adenosine in cardioprotective effect of catecholamine preconditioning in ischemia-reperfused heart of rat

Kim YH, Kim CH, Kim GT, Kim IK, Park JW, Kim MS

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):753-761.
Preconditioning of a heart with small doses of catecholamines induces a tolerance against the subsequent lethal ischemia. The present study was performed to find a specific receptor pathway involved with the catecholamine preconditioning...
Modulation of ATP-induced activation of the muscarinic K+ channel activity by protein kinase C

Kim YM, Park HK, Han JH, Park CO, Hong SG

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):743-753.
The atrial acetylcholine-activated K+ (KACh) channel is gated by the pertussis toxin-sensitive inhibitory G (GK) protein. Earlier studies revealed that ATP alone can activate the KACh channel via transphosphorylation mediated by nucleoside-diphosphate kinase...
Increase of L-type calcium current by cGMP-dependent protein kinase regulates in rabbit ventricular myocytes

Han J, Kim N, Kim E, Ho W, Earm YE, Kim H

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):733-742.
BACKGROUND: We have previously reported that not only cGMP but also 8-Br-cGMP or 8-pCPT-cGMP, specific and potent stimulators of cGMP-dependent protein kinase (cGMP-PK), increased basal L-type calcium current (ICa) in rabbit ventricular myocytes....
Decrease in Ca2+ storage in the cardiac sarcoplasmic reticulum of diabetic rat

Kim WT, Kim HW, Kim YK

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):725-732.
In order to elucidate the molecular mechanism of the intracellular Ca2+ overload frequently reported from diabetic heart, diabetic rats were induced by the administration of streptozotocin, the membrane vesicles of junctional SR (heavy...
Roles of Na+-Ca2+ exchange in the negative force-frequency relationship

Ko CM, Kim SJ

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):715-724.
Frequency-force relationships (FFR) were studied in electrically field stimulated rat left atria (LA) by reducing the stimulation frequency from resting 3 Hz to test frequencies (0.1-1 Hz) for 5 minutes. The twitch amplitudes...
Moderate elevation of extracellular K+ concentration induces vasorelaxation in isolated rat, rabbit and human cerebral arteries: Role of Na pump and Ba-sensitive process

Kim DH, Kim SJ, Lee SJ, Park SJ, Kim KW

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):705-714.
Cerebral blood vessels relax when extracellular K+ concentrations ((K+))e are elevated moderately (2~15 mM, K+-induced vasorelaxation). We have therefore studied the underlying mechanism for this K+-induced vasorelaxation in the isolated middle cerebral arteries (MCAs)....
Sensitivity of rabbit cerebral artery to serotonin is increased with the moderate increase of extracellular K+

Suh SH, Park SJ, Choi JY, Sim JH, Kim YC, Kim SJ, So I, Kim KW

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):695-703.
(K+)O can be increased under a variety of conditions including subarachnoid hemorrhage. The increase of (K+)O in the range of 5~15 mM may affect tensions of blood vessels and can change their sensitivity...
Microinjection of glutamate into the amygdala modulates nociceptive and cardiovascular response in freely moving rats

Ahn DK, Kim YS, Park JS

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):687-693.
This study was performed to examine the mean arterial pressure and nociceptive jaw opening reflex after microinjection of glutamate into the amygdala in freely moving rats, and to investigate the mechanisms of antinociceptive...
Effects of neonatal footshock stress on glucocorticoid and 5-HT2A/2C receptor bindings and exploratory behavior

Kim DG, Lee S, Kang DW, Lim JS

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):677-685.
To investigate the effects of neonatal stress on behavior and neurochemistry, rats were exposed to the footshock stress on postnatal day (PND) 14 or PNDs 14 and 21. Rats were exposed to...
Effects of dopamine and haloperidol on morphine-induced CREB and AP-1 DNA binding activities in differentiated SH-SY5Y human neuroblastoma cells

Kim SK, Kwon GY

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):671-676.
In the present study, we first examined whether the changes in the DNA binding activities of the transcription factors, cAMP response element binding protein (CREB) and activator protein-1 (AP-1) mediate the long-term effects...
Dopaminergic inhibition of dorsal horn cell activity in the cat

Kim KC, Shin HK, Kim KS

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):661-670.
Dopamine has been generally known to exert antinociceptive action in behavioral pain test, such as tail flick and hot plate test, but there appears to be a great variance in the reports...
Impairing effects of acute glucose overload on calcium homeostasis in vascular endothelial cells

Oike M, Kimura C

  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):653-659.
SUMMARY AND PERSPECTIVE We demonstrated two kinds of impairing effect of glucose overload on endothelial Ca2+ mobilization; i.e., 02- mediated and protein kinase C-mediated ones. As already mentioned in the...

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