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Increased activity of large conductance Ca2+-activated K+ channels in negatively-charged lipid membranes

Park JB, Ryu PD

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):529-539.
The effects of membrane surface charge originated from lipid head groups on ion channels were tested by analyzing the activity of single large conductance Ca2+-activated K+ (maxi K) channel from rat skeletal muscle....
cAMP-dependent signalling is involved in adenosine-stimulated Cl- secretion in rabbit colon mucosa

Oh SO, Kim EY, Jung JS, Woo JS, Kim YK, Lee SH

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):521-527.
An important property of the intestine is the ability to secrete fluid. The intestinal secretion is regulated by a number of substances including vasoactive intestinal peptide (VIP), ATP and different inflammatory mediators. One...
Protective mechanism of nitric oxide and mucus against ischemia/reperfusion-induced gastric mucosal injury

Kim H, Nam K, Kim KH

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):511-519.
This study investigated the role of nitric oxide on the oxidative damage in gastric mucosa of rats which received ischemia/reperfusion and its relation to mucus. Nitric oxide synthesis modulators such as L-arginine and...
Renal handling of sodium and potassium in cadmium exposed rats

Kim YK, Park YS

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):503-510.
Effects of cadmium exposure on renal Na+ and K+ transports were studied in rats. During the course of cadmium treatment (2 mg Cd/kg/day, s.c. injections for 3 weeks) renal tubular transports of...
Interaction of 17beta-estradiol with EGF and IGF-I on proliferation and Pi uptake in primary cultured rabbit renal proximal tubular cells

Han HJ, Lee YH

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):493-501.
The most significant direct role of estrogen in vivo is its ability to elicit receptor-mediated cellular proliferation in mammalian target tissues. However, the mechanism by which exogenously added estrogen causes the neoplastic transformation...
Effect of the inhibition of platelet activating factor on oxidative lung injury induced by interleukin-1 alpha

Lee YM, Park YY

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):479-491.
In order to know the pathogenesis of adult respiratory distress syndrome (ARDS) in association with the oxidative stress by neutrophils, the role of platelet activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine, PAF) was investigated during acute lung injury...
Acute cyclosporin A-treatment impairs the cytosolic guanylate cyclase-mediated vasodilatation in rat thoracic aorta

Kook H

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):471-477.
Cyclosporin A (CsA), a widely used immunosuppressant, is well known to cause nephrotoxicity and hypertension as major side effects. The present study was aimed at investigating the effects of CsA-pretreatment on the activities...
Pharmacological characterization of synthetic tetrahydroisoquinoline alkaloids, YS 51 and YS 55, on the cardiovascular system

Chang KC, Kang YJ, Lee YS, Chong WS, Yun-Choi H, Lee DH, Ryu JC

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):461-469.
Tetrahydroisoquinoline (THI) alkaloids can be considered as cyclized derivatives of simple phenylethylamines, and many of them, especially with 6,7-disubstitution, demonstrate relatively high affinity for catecholamines. Two -OH groups at 6 and 7 positions...
Altered renal nitric oxide system in experimental hypertensive rats

Yang ES, Kang J, Lee DG

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):455-460.
The present study was aimed at investigating whether the development of hypertension is related with an altered expression of nitric oxide synthases (NOS) in the kidney. By Western blot analysis, the expression of...
Mechanism of vasoactive intestinal polypeptide-induced catecholamine secretion from the rat adrenal medulla

Lim DY, Heo JB, Choi CH, Lim GH, Lee YG, Oh SH, Kim IS, Kim JI

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):443-454.
The present study was attempted to investigate the effect of vasoactive intestinal polypeptide (VIP) on secretion of catecholamines (CA) and to establish whether there is the existence of a noncholinergic mechanism in adrenomedullary...
Rapid induction of mRNA for prostaglandin H synthase in ovine meningeal fibroblasts

Nam MJ, Thore C, Busija D

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):435-441.
We examined effects of interleukin 1 alpha (IL1 alpha) and phorbol 12, 13 dibutyrate (PDB), an activator of protein kinase C, on mRNA for Prostaglandin H synthase (PGHS) and prostanoid production in...
Cytoprotective effects of dihydrolipoic acid and lipoic acid on the oxidative stress in cultured rat cortical neurons

Kim WK

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):427-433.
In brain hypoxic-ischemia, an excess release of glutamate and a marked production of reactive oxygen species (ROS) occur in neuronal and non-neuronal cells. The present study investigated the effect of the biological antioxidants...
Effects of exogenous ATP on calcium mobilization and cell proliferation in C6 glioma cell

Lee EJ, Cha SH, Lee WK, Lee KH, Lee SB

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):419-425.
To clarify the effect of extracellular ATP in cultured C6 glioma cells, ATP-induced cytosolic free calcium ((Ca2+)i) mobilization and cell proliferation were investigated. ATP-induced (Ca2+)i increased in a dose-dependent manner (10-7 M apprx...
Mediation of intracellular Ca2+ in the phospholipase A2-induced cell proliferation in human neuroblastoma cells

Kim JA, Lee YS

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):411-417.
The role of phospholipase A2 (PLA2) in tumor cell growth was investigated using SK-N-MC human neuroblastoma cells. 4-Bromophenacyl bromide (BPB) and mepacrine (Mep), known PLA2 inhibitors, suppressed growth of the tumor cells in...
The K+ channels of colonic crypts and their regulation

Greger R, Hamm K, Warth R, Nielsen M, Weyand B, Ecke D, Riedemann , Gerlach U, Busch AE, Englert HC, Hropot M, Lang HJ, Bleich M

  • Korean J Physiol Pharmacol.
  • 1998 Aug;2(4):403-409.
No abstract available.

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