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Cytochrome P450 2E1 activity in a Korean population

Muhn DH, Chae JM, Bahn JY, Song HJ, Kim HK, Kwon JT, Sohn DR

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):597-602.
Cytochrome P450 2E1 (CYP2E1) is involved in the toxicity and carcinogenicity of a number of solvents and xenobiotics. Like the various types of oxidation pharmacogenetics, the activity of the enzyme shows a discernible...
Thiobenzamide S-oxidation in perfused rat liver: Ex vivo determination of hepatic flavin-containing monooxygenase activity

Chung WG, Roh HK, Cha YN

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):591-595.
An ex vivo assay determining the flavin-containing monooxygenase (FMO) activity in perfused rat liver has been developed by assessing the rate of thiobenzamide S-oxide (TBSO) formation from the infused thiobenzamide (TB). The hepatotoxicity...
Effect of UV irradiation and rebamipide on the blood flow and viability of rabbit skin flap

Suh EJ, Choi HC, Sohn UD, Ha JH, Lee KY, Kim WJ

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):581-589.
This study was undertaken to examine the effects of ultraviolet light (UVL) and rebamipide on the cutaneous blood flow and tissue survival on rabbit skin flap. In a random bipedicle flap, Laser...
The inhibitory effect of eupatilin on Helicobacter pylori-induced release of leukotriene D4 in the human neutrophils and gastric mucosal cells

Lee JJ, Han BG, Kim MN, Chung MH

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):573-580.
In this report, the inhibitory action of eupatilin was investigated by using leukotriene D4 in the human neutrophils and Kato III cells (Gastric adenoma cells as a substitute for gastric mucosal cells) stimulated...
Endothelin increases intracellular free calcium in isolated rat nephron

Cha SH, Cho YJ, Lee KH, Endou H

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):565-572.
In the freshly isolated rat nephron, the effect of endothelin-1, -2 and -3 (ET-1, -2 and -3) on cytosolic free calcium concentration ((Ca2+)i) was determined using the fluorescent indicator Fura-2/AM. (Ca2+)i increase was...
Effect of pH on the ATP-sensitive K+ channel in aortic smooth muscle cells from rats

Kim SH, Kim IS, Kim HS, Jeon BH, Chang SJ

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):555-563.
The effects of pH on K+ currents were investigated in single smooth muscle cells isolated from the thoracic aorta of Wistar-Kyoto rats. Whole-cell K+ currents were recorded in the conventional configuration of the...
Role of tyrosine kinases in vascular contraction in deoxycorticosterone acetate-salt hypertensive rats

Yeum CH, Jun JY, Choi HS

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):547-553.
It has been known that activation of tyrosine kinases is involved in signal transduction. Role of the tyrosine kinase in vascular smooth muscle contraction was examined in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Male...
Role of intracellular taurine in monensin-induced Na+, Ca++ accumulation and mechanical dysfunction in isolated rat hearts

Kim YH, Park JW, Kim MS

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):537-546.
It has been postulated that the intracellular taurine is co-transported with Na+ down a concentration gradient and prevents the intracellular accumulation of sodium. It is therefore, expected that an elevated level of intracellular...
Altered vascular calcium regulation in hypertension

Kim WJ, Lee JU, Park YH, Nam SC

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):529-535.
The present study was aimed at investigating whether the vascular calcium regulation is altered in hypertension. Two-kidney, one clip (2K1C) and deoxycorticosterone acetate (DOCA)-salt hypertension were made in rats, and their thoracic aortae...
Changes of renal peripheral benzodiazepine receptor in the stress/anxiety response

Ha JH, Lee KH, Cheung SD, Park HB, Lee MG, Choi HC, Sohn UD, Lee KY, Kim WJ

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):523-528.
Peripheral benzodiazepine receptor(PBR) has been identified in various peripheral tissues including kidney. The physiological and pharmacological functions of PBR are still uncertain, although it has been suggested that these are associated with the...
Nitric oxide prevents the bovine cerebral endothelial cell death induced by serum-deprivation

Kim CH, Ahn YS

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):515-521.
Endothelial cells play a central role in the inflammatory processes, and activation of nuclear factor kappa B (NF-kappaB) is a key component in that inflammatory processes. Previously, we reported that tumor necrosis factor...
Correlation between electrical activity of type I neuron and c-Fos expression in the medial vestibular nuclei following unilateral labyrinthectomy in rats

Park BR, Doh NY, Kim MS, Chun SW, Lee MY, Lee SH

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):505-513.
To search the correlations between electrical activity and c-Fos expression in the process of vestibular compensation, we examined the changes of those two parameters in the medial vestibular nuclei (MVN) of unilaterally labyrinthectomized...
Regulation of AQP-4 water channel expression in the brain during development and by ischemia

Jung JS, Kim HG, Bae HR, Suh DJ, Tae PH, Lee SH

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):495-504.
Water transport is mediated by two distinct pathways, diffusional and channel-mediated water transport. The first molecular water channel was identified from human erythrocytes in 1992. Genetically-related proteins from other mammalian tissues have subsequently...
alpha-Adrenergic and cholinergic receptor agonists modulate voltage-gated Ca2+ channels

Nah SY, Kim JH, Kim CH

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):485-493.
We investigated the effect of alpha-adrenergic and cholinergic receptor agonists on Ca2+ current in adult rat trigeminal ganglion neurons using whole-cell patch clamp methods. The application of acetylcholine, carbachol, and oxotremorine (50 muM...
Blockade of intrinsic oscillatory activity of cerebellar Purkinje cells by apamin and nickel

Seo W, Strahlendorf JC, Strahlendorf HK

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):477-484.
Intracellular recordings of oscillatory firing (bursting activity) were obtained from Purkinje cells (PCs) in rat cerebellar slices. Apamin inhibited post-burst hyperpolarizations (PBHs) progressively and finally terminated oscillatory firing activity of PCs. Apamin did...
Differential inhibitory action of taurine between electrically evoked response and low Mg++/-induced spontaneous activity in the CA1 area of the rat hippocampal slices

Baek SY, Yang SG, Lee CJ

  • Korean J Physiol Pharmacol.
  • 1997 Oct;1(5):467-475.
Although one of the major physiological functions of taurine (2-aminoethanesulfonic acid) is the inhibitory action on the central nervous system (CNS), the mechanism of taurine in controlling the neuronal excitation in the CNS...

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