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Induction of apoptosis by bile acids in HepG2 human hepatocellular carcinoma cells

Baek JH, Kim JA, Kang CM, Lee YS, Kim KW

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):107-115.
We studied the effects of bile acids on the induction of apoptosis in HepG2 human hepatocellular carcinoma cells. Treatment with either ursodeoxycholic acid (UDCA) or lithocholic acid (LCA) resulted in a dose- and...
Comparison of regulatory action of cAMP and cGMP on the activation of neutrophil responses

Han CH, Yoon YC, Shin YK, Han ES, Lee CS

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):97-105.
The regulatory role of cyclic nucleotides in the expression of neutrophil responses has been examined. fMLP-stimulated superoxide production in neutrophils was inhibited by dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP), histamine, adenosine + theophylline, cAMP elevating...
Lipocortin 1 mediates the suppressive effects of dexamethasone on CoNinduced proliferative response and nitric oxide production in rat splenic leukocytes

Jang YJ, Park H, Kang SA, Yan SJ, Na DS

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):91-96.
Lipocortin 1 has been proposed as a putative mediator of anti-inflammatory actions of glucocorticoids. We investigated the role of lipocortin 1 in the effect of dexamethasone using rat splenic leukocytes. Concanavalin A(ConA; 1-microgram/ml)...
Mechanism of action of pancreatic polypeptide (PP) on pancreatic exocrine secretion in isolated rat pancreas

Lee YL, Kwon HY, Park HS, Park HJ

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):83-90.
Aim of this study was to investigate if pancreatic polypeptide (PP) reduced the insulin action via the intra-pancreatic cholinergic nerves in the isolated rat pancreas. The pancreas was isolated from rats and perfused...
Regulatory role of nitric oxide on atrial natriuretic peptide system in normotensive and hypertensive rats

Choi EH, Kim M, Lee JU

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):79-82.
The present study was aimed to explore an interaction between endothelium-derived nitric oxide (NO) and atrial natriuretic peptide (ANP) systems in normotensive and hypertensive states. Rats were made two-kidney, one clip (2K1C) hypertensive...
Inhibition of phospholipase A-2 diminishes the acute alveolar injury induced by interleukin-1-alpha

Lee YM

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):71-78.
In an attempt to investigate the role of phospholipase A-2(PLA-2) in interleukin-1 (IL-1) induced acute lung injury, mepacrine was tried to inhibit PLA-2 in IL-1 induced ARDS rats. For confirmation of acute...
ANP inhibits surfactant secretion from isoproterenol stimulated alveolar type II cells

Lee YM

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):65-70.
In order to investigate the effect of ANP on surfactant secretion from alveolar type II cell(AT II cell) during circulatory derangement in adult respiratory distress syndrome (ARDS), the secretion of surfactant from AT...
Renal mRNA expression of renin, AT-1 receptor, TGF-beta-1 and fibronectin in obstructive nephropathy

Yang EK, Kim IK

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):55-63.
The present study was designed to quantify the alterations of renal renin, angiotensin type I receptor (AT-1), TGF-beta-1, and fibronectin gene expression in rats with unilateral ureteral obstruction (UUO). We also investigated the...
Gene expression of intrarenal renin-angiotensin system in streptozotocin-induced diabetic rats

Yang EK, Kim IK

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):45-53.
In humans and many animal models with chronic progressive renal diseases, angiotensin-converting enzyme (ACE) inhibitor markedly attenuates the progression of nephropathy. Several studies have reported augmented gene expression and redistribution of renal renin...
Effect of cisplatin on sodium-dependent hexose transport in LLC-PK-1 renal epithelial cells

Lee SK, Kim JY, Yu TH, Kim KR, Kim KH, Park YS

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):35-43.
Cis-dichlorodiammine platinum II (Cisplatin), an effective chemotherapeutic agent, induces acute renal failure by unknown mechanisms. To investigate direct toxic effects of cisplatin on the renal proximal tubular transport system, LLC-PK-1 cell line was selected...
Pharmacological evidence that cromakalim inhibits Ca2+ release from intracellular stores in porcine coronary artery

Rhim BY, Hong SH, Kim CD, Lee WS, Hong KW

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):27-34.
In the present study, it was aimed to further identify the intracellular action mechanism of cromakalim and levcromakaliin in the porcine coronary artery. In intact porcine coronary arterial strips loaded with fura-2/AM, acetylcholine...
Enhanced coupling of M-1 muscarinic receptors to activation of phospholipase C upon mutation of a transposed amino acid triplet repeat

Lee SY, Sung KW, Kim ON, Lee SB

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):19-25.
The C-terminus ends of the second putative transmembrane domains of both M-1 and M-2 Muscarinic receptors contain a triplet of amino acid residues consisting of leucine (L), tyrosine (Y) and threonine (T). This...
Regulation of adenosine receptors in rat brain following chronic carbamazepine treatment

Park KS, Yang WS, Kim KH

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):13-17.
Carbamazepine (CBZ), an anticonvulsant, has been reported to displace ligands at adenosine receptors. Several studies have demonstrated that as far as A-2 adenosine receptors is concerned, CBZ acts as an antagonist. However, the...
The role of adenosine receptors on acetylcholine release in the rat striatum

Kim DK, Kim HA, Choi BK

  • Korean J Physiol Pharmacol.
  • 1997 Feb;1(1):1-12.
As it has been reported that the depolarization induced acetylcholine (ACh) release is modulated by activation of presynaptic A-1 adenosine heteroreceptor and various evidence suggest that indicate the A-2 adenosine receptor is present...

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