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Association of dexamethasone-induced apoptosis of G|1-arrest of human leukemic CEM cells with polyamine deficit

Choi SH, Lee JA, Chae YS, Min BH, Chun YS, Chun BG

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):457-466.
The effects of DFMO or/and putrescine on the dexamethasone-induced apoptosis of CEM cells were studied to investigate the role of polyamines in anti-leukemic glucocorticoid action. Dexamethasone-induced apoptosis was preceded by significant decreases of cellular...
Effects of ginsenosides on the mechanism of histamine release in the guinea pig lung mast cells activated by specific antigen-antibody reactions

Ro JY, Ahn YS, Kim KH

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):445-456.
We previously reported that some components of ginsenosides decreased mediator releases evoked by the activation of mast cells with specific antigen-antibody reactions. This study aimed to assess the effects of ginsenosides (Rb2, Re)...
Effects of arachidonic acid on the calcium channel current (I|B|a) and on the osmotic stretch-induced increase of I|B|a in guinea-pig gastric myocytes

Xu WX, Kim SJ, So I, Suh SH, Kim KW

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):435-443.
We employed the whole-cell patch clamp technique to investigate the effects of arachidonic acid (AA) on barium inward current through the L-type calcium channels (IBa) and on osmotic stretch-induced increase of IBa in...
Regulatory mechanisms of angiotensin II on the Na+/H+ antiport system in rabbit renal proximal tubule cells. II. Inhibitory effects of ANG II on Na+ uptake

Han HJ, Park SH, Koh HJ

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):425-434.
Many reports represent that angiotensin II (ANG II) caused a dose dependent biphasic effects on fluid transport in the proximal tubule. However, respective roles of different signaling pathways in mediating these effects remain...
Regulatory mechanisms of angiotensin II on the Na+/H+ antiport system in rabbit renal proximal tubule cells. I. Stimulatory effects of ANG II on Na+ uptake

Han HJ, Koh HJ, Park SH

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):413-423.
The importance of the kidney in the development of hypertension was first demonstrated by Goldblatt and his colleagues more than fifty years ago. Many hormones and other regulatory factors have been proposed to...
Changes in renal brush-border sodium-dependent transport systems in gentamicin-treated rats

Suhl SY, Ahn DW, Kim KR, Kim JY, Park YS

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):403-411.
To elucidate the mechanism of gentamicin induced renal dysfunction, renal functions and activities of various proximal tubular transport systems were studied in gentamicin-treated rats (Fisher 344). Gentamicin nephrotoxicity was induced by injecting gentamicin...
Mechanisms underlying relaxations caused by angiotensin II and its analogs in isolated rabbit mesenteric artery

Hong KW, Park JY, Kim CD, Lee WS, Rhim BY, Yoo SE

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):393-402.
In the present study, we characterized the angiotensin II (AII)-induced relaxations in the phenylephrineprecontracted rabbit mesenteric arteries with endothelium. 1) AII-induced relaxation was consistently observed in the rabbit mesenteric arteries with and without endothelium,...
Distributional patterns of phospholipase C isozymes in heart and brain of spontaneously hypertensive and normotensive rats

Choi JW, Cho YJ, Cha SH, Lee KH, Lee SB

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):385-392.
The phospholipase C (PLC)-mediated intracellular signal transduction pathway is considered to be involved in the regulation of blood pressure. However, little information is available concerning the distributional and functional significance of PLC in...
(3H)Ryanodine binding sites of SR vesicles of the chicken pectoral muscle

Yun HY, Jeon JR, Hong JH, Hur GM, Lee JH, Seok JH

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):377-384.
To investigate the properties of ryanodine binding sites of the bird skeletal SR vesicles, SDS PAGE, purification of RyR, and (3H)ryanodine binding study were carried out in the SR vesicles prepared from...
Effect of t-butylhydroperoxide on Na+/-dependent glutamate uptake in rabbit brain synaptosome

Lee HJ, Kim YK

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):367-376.
The effect of an organic peroxide, t-butylhydroperoxide (t-BHP), on glutamate uptake was studied in synaptosomes prepared from cerebral cortex. t-BHP inhibited the Na+/-dependent glutamate uptake with no change in the Na+/-independent uptake. This...
Spontaneous electrical activity in cerebellar Purkinje neurons of postnatal rats

Nam SC

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):355-366.
Although cerebellar Purkinje cells display spontaneous electrical activity in vivo and in slice experiments, the mechanism of the spontaneous activity generation has not been clearly understood. The aim of this study was to...
Effect of Panax ginseng on latency of passive avoidance response and neuronal damage of hippocampus

Cho SH, Choi SH, Choi JW, Kim DH, Shin KH, Chun YS, Chun BG

  • Korean J Physiol Pharmacol.
  • 1997 Aug;1(4):345-353.
The effects of crude saponin (SAP) and alkaloid (ALK) fractions of Panax ginseng C.A. Meyer on the detrimental effects of electroconvulsive shock (ECS) and scopolamine on passive avoidance response (PAR) were studied...

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