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12 results

Melatonin enhances hepatic glutathione-peroxidase activity in Sprague-Dawley rats

Kim CY, Yun CS, Park DH, Choi WS, Kim JS

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):221-224.
Effects of melatonin on hepatic glutathione-peroxidase (GSH-Px) and glutathione-reductase (GSH-reductase) activities were studied in Sprague-Dawley (SD) rats administered i.p. (10 mg/kg body weight) with melatonin during 15 days. The activity of cytosolic GSH-reductase...
Reduction of TNF alpha-induced oxidative DNA damage product, 8-hydroxy-2'-deoxyguanosine, in L929 cells stably transfected with small heat shock protein

Park YM, Choi EM

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):209-219.
Previous studies have demonstrated that oxidative stress involving generation of reactive oxygen species (ROS) is responsible for the cytotoxic action of TNF alpha. Protective effect of small heat shock proteins (small HSP) against...
Platelet-activating factor enhances interleukin-1 activity by alveolar macrophages: Inhibition by PAF specific receptor antagonists

Lee J

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):201-208.
It is becoming increasingly clear that the inflammatory reaction can be ascribed to a complex array of mediators generated and released from activated phagocytes. In this study, the effect of PAF on interleukin-1(IL-1)...
Cloning of mouse AQP-CD gene

Jung JS, Kim JI, Oh SO, Park MY, Bae HR, Lee SH

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):195-200.
Water transport in highly-permeable membranes is facilitated by some specialized pathways, which are called aquaporins (AQP). AQP1 (AQP-CHIP) is the first recognized aquaporin identified from red cells and renal proximal tubules. Up until...
Functional characteristics of neutral amino acid transporter in opossum kidney (OK) cells

Woo JS, Park MH, Oh SO, Jung JS, Kim YK, Lee SH

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):185-193.
The characteristics of Na+/-dependent cycloleucine uptake was investigated in OK cells with regard to substrate specificity and regulation by protein kinase C (PKC). Inhibition studies with different synthetic and natural amino acids showed...
Two types of voltage-dependent outward potassium currents in smooth muscle cells of rabbit basilar artery

Kang TM, So I, Uhm DY, Kim KW

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):169-183.
We have investigated the two types of voltage-dependent outward potassium (K) currents, i.e. delayed rectifier K current (I-K(V)) and 'A-like' transient outward K current (I-to) with patch-clamp technique in single smooth muscle cells...
Neural adaptation of beta adrenergic receptor subtypes after chronic imipramine treatment: A quantitative autoradiographic study

Park HY, Hong YS, Park CW

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):161-167.
This study compares the subtypes of central beta adrenergic receptors (ARs) of brains of untreated rats with those of imipramine-treated rats. Beta adrenergic receptors were measured by quantitative autoradiography of the binding of...
Effect of hemorrhage on mRNA expressions of renin, angiotensinogen and AT-1 receptors in rat central and peripheral tissues

Lee MK, Jo H, Kim KS, Yang EK, Lee WJ

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):151-159.
In an attempt to investigate whether hemorrhage affects the gene expression of the renin-angiotensin system (RAS) components in the brain and peripheral angiotensin-generating tissues, changes in mRNA levels of the RAS components in...
Study on ginseng protopanaxadiol and protopanaxatriol saponins-induced antinociception

Shin YH, Kim SC, Han JW, Kim DH, Han SS, Shin DH, Nah SY

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):143-149.
We studied the effects of ginseng protopanaxadiol (PD) and protopanaxatriol (PT) saponins on the analgesia using several pain tests such as writhing, formalin, and tail-flick test. Using mouse, pretreatment of PD or PT...
The influence of N-6-cyclopentyladenosine and magnesium on norepinephrine release in the rat hippocampus

Park YB, Park SD, Choi BK

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):135-142.
As it has been reported that the depolarization-induced norepinephrine (NE) release is modulated by activation of presynaptic A-1-adenosine heteroreceptor and various lines of evidence indicate that A-2-adenosine receptor also presents in hippocampus, and...
Lithium-induced increase of synaptosomal uptake of norepinephrine in rat brain

Cho YW, Han SH, Kim CJ, Min BI

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):127-133.
Lithium remains the most widely used therapeutic agent for bipolar affective disorder, particularly mania. Although many investigators have studied the effects of lithium on abnormalities in monoamine neurotransmitter as a pathophysiological basis of...
(3H)MK-801 binding to the synaptic membranes of rat forebrains: Age-related regulation by glutamate, glycine and spermine

Cho J, Kong JY

  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):117-125.
The N-methyl-D-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission is involved in synaptic plasticity, developmental processes, learning and memory and many neuropathological disorders including age-related diseases. In the present study, regulation of the NMDA receptor properties by...

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