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Chronic Myelogenous Leukemia with a Variant Philadelphia Translocation: t(11;22)(q25;q11.2)

Kim HS, Cho HC, Kim SH, Moon Y, Nahm CH, Choi JW, Kim JJ

We report a case of chronic myelogenous leukemia displaying a variant Philadelphia translocation t(11;22)(q25;q11.2). Breakpoint 11q25 has not previously been reported. Reverse transcriptase polymerase chain reaction and fluorescence in-situ hybridization...
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Networking Experience of Point-of-Care Test Glucometer

Park AJ, Kim HR, Lee MK

BACKGROUND: Clinical laboratories are selecting total solutions to point-of-care test (POCT) by handling all aspects of information management ranging from the ordering of the test to the reporting of verified...
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Comparison of 3 Automated Immunoassays for Hepatitis B Surface Antigen

Yoo SJ, Oh HJ, Shin BM

BACKGROUND: Hepatitis B surface antigen (HBsAg) is one of the most important serological markers used to diagnose hepatitis B virus (HBV) infection. Automated immunoassays have been developed, meeting the current...
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In Vitro Susceptibilities to Caspofungin and Micafungin of Clinical Isolates of Candida Species

Choi HW, Shin JH, Lee JS, Cho D, Shin MG, Suh SP, Ryang DW

BACKGROUND: Caspofungin and micafungin are echinochandins with potent activities against Candida species. However, in vitro susceptibility to these agents of clinical Candida isolates in Korea has not been fully surveyed....
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Diagnostic Usefulness of SD Malaria Antigen and Antibody Kits for Differential Diagnosis of vivax Malaria in Patients with Fever of Unknown Origin

Park TS, Kim JH, Kang CI, Lee BH, Jeon BR, Lee SM, Chang CL, Lee EY, Son HC, Kim HH

BACKGROUND: Examination of peripheral blood smear (PBS) is the gold standard for the diagnosis of malaria; however, its diagnostic utility will be dependent on the examiner's microscopic experience, the quality...
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Distribution of T types and emm Genotypes of Streptococcus pyogenes in Jinju, 2004

Koh EH, Kim S

BACKGROUND: T antigens and emm genotypes are useful markers for epidemiologic investigation of Streptococcus pyogenes infections. Epidemiologic studies of S. pyogenes were performed on a large scale in Jinju. This...
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Evaluation of Plasma Homocysteine Assay by ADVIA Centaur Analyzer

Choi JS, Kim IS, Lee SY, Kim JW

BACKGROUND: Hyperhomocysteinemia is a risk factor for the cardiovascular diseases that can be usually reversed with vitamin supplements. Quantitative analysis of homocysteine helps to identify patients who might get benefits...
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Biphenotypic Acute Leukemia with BCR-ABL mRNA Transcript b3a2 Type: A Case Report with Review of the Literature

Choi HW, Shin MG, Kim HJ, Lee IK, Yun JH, Kim HR, Kim YK, Yun HK, Cho D, Kee SJ, Shin JH, Suh SP, Ryang DW

Biphenotypic acute leukemia (BAL) is a subtype of leukemia of ambiguous lineage in the World Health Organization classification system. About one third of the cases have the Philadelphia chromosome, and...
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Modulation of Telomerase Activity and Human Telomerase Reverse Transcriptase Expression by Caspases and Bcl-2 Family Proteins in Cisplatin-Induced Cell Death

Park YP, Choi SC, Cho MY, Song EY, Kim JW, Paik SG, Kim YK, Kim JW, Lee HG

BACKGROUND: Human telomerase is a ribonucleoprotein polymerase, which synthesizes telomeric repeat sequences, and human telomerase reverse transcriptase (hTERT) has been identified as the catalytic subunit, as well as the rate-limiting...
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Quality Evaluation of the Performance Study of Diagnostic Tests Using STARD Checklist and Meta-Analysis for the Pooled Sensitivity and Specificity of Third Generation Anti-HCV EIA Tests

Kim S, Oh HB, Cha CH, Choi SE, An HY, Lee KJ

BACKGROUND: The third generation anti-hepatitis C virus (HCV) enzyme immunoassay (EIA) is now in use for screening HCV infection. The aim of this study was to pool the data on...
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Development of a Web-based Program to Calculate Sample Size for Evaluating the Performance of In Vitro Diagnostic Kits

Hwang SH, Oh HB, Chae JM, Seo MK, Jung SY, Choi SE, Lee KJ

BACKGROUND: Many studies evaluating the performance of in vitro diagnostic kits have been criticized for the lack of reliability. To attain reliability those evaluation studies should be preceded by sample...
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FLT3 Gene Mutations as a Prognostic Factor for Acute Myeloid Leukemia

Chang SH, Lee NY, Kim DH, Sohn SK, Suh JS

BACKGROUND: Two distinct types of fms-like tyrosine kinase 3 (FLT3) gene mutations have been identified in acute myeloid leukemia (AML): D835 and internal tandem duplication (ITD) mutations. These mutations are...
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Erythroleukemic Blast Crisis of Chronic Myeloid Leukemia

Chung HJ, Chi HS, Seo EJ, Jang S, Park CJ, Lee KH

Erythroleukemic blast crisis of chronic myeloid leukemia (CML) is very rare. We report two cases of erythroleukemic blast crisis of CML resistant to imatinib treatment. Both patients made a rapid...
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