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Recurrent Pneumomediastinum and Subcutaneous Emphysema Complicating Chronic Graft versus Host Disease after Allogeneic Bone Marrow Transplantation

Lee NR, Lee TH, Song EK, Kwak JY, Yim CY

Several noninfectious pulmonary complications can be associated with chronic graft versus host disease (GVHD). Obstructive airway disease can be a clinical feature of chronic GVHD and the histopathology reveals characteristic...
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Triplication of 1q in a Patient with Myelodysplastic Syndrome

Cho HS, Kim MK, Hyun MS

Triplication of 1q is a very rare chromosomal abnormality in hematologic malignancies, and it has been related to Fanconi anemia. The clinical significance of this abnormality is unknown. We report...
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Regression of Extensive Colonic Extranodal Marginal Zone B Cell Lymphoma after Treatment with Rituximab

Song EK, Lee NR, Yim CY

We report here on a case of colonic extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) in a 17-year-old male with a history of selective IgA deficiency....
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A Patient with IgA Monoclonal Gammopathy Presenting as Myelomatous Pleural Effusion with Axillary Node Involvement

Park SJ, Sung HJ, Kim JH, Song JW, Song KS

Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin, and the neoplastic plasma cells typically accumulate in the bone marrow with occasional involvement of other organs. Pleural...
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A Case of Acute Lymphoblastic Leukemia with Maturation

Kim JH, Lee WI, Park SY, Yoon HJ, Kang SY, Suh JT

Acute lymphoblastic leukemia with maturation (ALLm) has different disease characteristics that does typical ALL. ALLm is characterized by an increased number of mature appearing leukemic cells (>20% of ANCs in...
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Overexpression of the Fanconi Anemia A Gene in Hela and MCF10A Cells

Park WH

BACKGROUND: Fanconi Anemia (FA) is an autosomal recessive inherited disease, which is characterized by developmental abnormalities, progressive bone marrow failure and a predisposition to cancer. The phenotypes of FA cells...
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A Case of Steroid Refractory Acute GVHD Treated with IL-2 & TNF-alpha Blocker in a Myelodysplastic Syndrome Patient who Underwent Unrelated Allogeneic Stem Cell Transplantation

Lee HH, Ahn MJ, Choi CU, Park SR, Baek YH, Sohn W, Lee DJ, Chang MH, Choi JH, Lee YY, Kim IS, Park CK

Hematopoietic stem cell transplantation has evolved as a central treatment modality for the management of various hematologic malignancies. Despite adequate posttransplantation immunosuppressive therapy, acute GVHD remains a major cause of...
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Pre-transplant Disease Status is Important for an Improved Outcome of the Second Stem Cell Transplantation in the Myeloma Patients Receiving the First Autologous Stem Cell Transplantation

Eom KS, Min CK, Lee S, Kim YJ, Kim SY, Cho SG, Lee JW, Min WS, Kim CC

BACKGROUND: Double autologous stem cell transplantation (ASCT) seems to be superior to a single ASCT, at least in the patients who did not achieve a 90% response after the first...
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Selective Expansion of Natural Killer Cells from Peripheral Blood Mononuclear Cells by K562 Cell Line and IL-2

Cho D, Shin SW, Park JS, Kang HK, Kim SK, Pham TN, Zhu XW, Shin MG, Suh SP, Ryang DW, Nam JH, Kim YJ, Lee JJ

BACKGROUND: Several attempts have been made to expand human NK cells from peripheral blood mononuclear cells (PBMCs). This study examined the selective expansion of NK cells using interleukin 2 (IL-2)...
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T-Cell Chimerism Analysis by Mutiplex STR PCR after Non-Myeloablative Allogeneic Stem Cell Transplantation

Goh RY, Han JY, Han H, Kim JS, Kwon HC, Kim SH, Kim HJ

BACKGROUND: The ability of non-myeloablative allogeneic stem cell transplants to eradicate host neoplastic cells is based on the accumulating evidence of a graft-versus-malignancy (GVM) effect. Stable mixed chimerism (MC) is...
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Clinical Characteristics of Autosomal Dominant Giant Platelet Syndromes and Mutation Analysis of MYH9

Kook H, Nam HS, Baek HJ, Kim YO, Eom GH, Kee HJ, Cho D, Shin MG, Lee JJ, Kim HJ, Kook H, Hwang TJ

BACKGROUND: The autosomal dominant giant platelet syndromes (GPS), characterized by triads of giant platelets, thrombocytopenia, and Dohle-like leukocyte inclusions are caused by MYH9 mutation, a gene encoding the nonmuscle myosin...
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