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Reversal of Marrow Fibrosis Following Imatinib Mesylate Therapy in a Patient with Chronic Myelogenous Leukemia Who Was Refractory to Interferon-alpha

Kim YS, Kim TH, Kim WC, Jeon YJ, Kil UH, Lee HK, Kim YS, Rho SY, Cho SG

No abstract available.
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A Case of Promyelocytic Leukemia with Basophil-like Granules

Jun KR, Chi HS, Park CJ, Jang SS, Lee KH

According to the FAB (French-American-British) classification, two main cytological subtypes are recognized: the classical hypergranular and the microgranular variant. However, other morphological variants have been reported in the literature. Therefore,...
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A Case of Lymphomatoid Papulosis after Allogenic Bone Marrow Transplatation

Choi JM, Lee HW, Kang SY, Jang JH, Park JS, Choi JH, Lim HY, Kim HC, Lee ES

A twenty-year-old man developed pruritic papules on his right forearm on the 25th day after an allogeneic bone marrow transplantation from an HLA-matched related donor. The skin lesion turned out...
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Arsenic Trioxide Induces Erythroid Differentiation and Apoptosis of K562 Human Leukemia Cells through the Down-Regulation of Bcl-2

You YK, Cheong HJ, Won JH, Kim SJ, Bae SB, Kim CK, Lee NS, Lee KT, Park SK, Hong DS, Park HS

BACKGROUND: Arsenic trioxide (As2O3) has been identified as an effective drug for the treatment of acute promyelocytic leukemia (APL). However, the role of As2O3 during the erythroid differentiation of human...
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A Case of Systemic Sclerosis Developed after Autologous Hematopoietic Stem Cell Transplantation in the Patient with Multiple Sclerosis

Kim WS, Min CK, Yang DW, Park YK, Choi SO, Kim JS, Lee H, Cho CS

Herein, the case of a 43-year-old woman, with a relapsing-remitting variant of multiple sclerosis (MS), which began when she was 34 years of age, and gave rise to severe neurological...
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A Case of Autoimmune Hemolytic Anemia after Fludarabine Treatment in Waldenstrom Macroglobulinemia

Moon SH, Chung SH, Jung DS, Lee CJ, Seo BG, Kim SH, Kwon HC, Kim JS, Kim HJ

Waldenstrom macroglobulinemia, which is characterized by elevation of serum monoclonal IgM paraprotein, has recently been responsible for the treatment of purine analogues. Fludarabine, one of purine analogues, has been associated...
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Aggressive Systemic Mastocytosis Following Ovarian Germ Cell Tumor

Huh EJ, Park SY, Choi SR, Chung SY, Kang JH, Kim KM, Lee JH, Jeong DC

A 4 years-old girl was diagnosed with aggressive systemic mastocytosis at 2 months after the end of chemotherapy including cisplatin, bleomycin and etoposide for an ovarian germ cell tumor (GCT)....
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Eugenol Induces a Reactive Oxygen Species-mediated Apoptosis in HL-60 Human Promyelocytic Leukemia Cells

Kil UH, Lee KH, Lee KT, Jin JY

BACKGROUND: Eugenol is a major component of the essential oil isolated from Eugenia caryophyllata (Myrtaceae), and has been widely used as a traditional medicine. In this study, the effects of...
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The Long Term Remission Effect of Rituximab in Two Patients with Autoimmune-associated Cytopenias that were Refractory to Standard Treatments

Park SJ, Han CW

Rituximab, anti-CD20 chimeric monoclonal antibody directed against the CD20 antigen on B lymphocytes, induces a targeted B lymphocytes depletion in the aim of eradicating autoreactive clones in various autoimmune disorders....
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Clinical Resistance to the Tyrosine Kinase Inhibitor Imatinib (STI571) and Detection of BCR-ABL Gene Mutations in Korean Patients with Chronic Myeloid Leukemia

Sohn YH, Chi HS, Park CJ, Lee KH, Seo EJ

BACKGROUND: Imatinib mesylate, the tyrosine kinase activity of the BCR-ABL fusion gene, induces a remarkable remission in chronic myeloid leukemia (CML) patients. However, resistance to imatinib has been observed in...
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Apoptosis Induction by Curcumin in Human Myelogenous Leukemia Cell Lines

Cho YH, Kim YJ, Park JW, Ahn KS, Kim IH, Bae EK, Park SY, Kim BK, Yoon SS

BACKGROUND: Curcumin, a naturally occurring biologically active compound extracted from rhizomes of Curcuma species, has been shown to possess potent anti-inflammatory, anti-tumor and anti-oxidative properties. The effects and possible mechanism...
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