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A Clinical Study on the Diabetic Foot Wound

Kim JY, Lee KT, Young KW, Hwang SK

PURPOSE: To make protocol on diabetic foot ulcer, with making use of this protocol, investigate hospitalized patients who have had diabetic foot wound and define pattern, characteristics and problems of...
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Pedometer-Determined Physical Activity in Type 2 Diabetes in Korea

Chang SA, Lee JM, Sohn TS, Son HS, Park SW, Baik SH, Yu JM, Sung YA, Ahn CW, Min KW, Han KA

BACKGROUND: Walking is a popular, convenient and relatively safe form of exercise. However, there is few objective data for walking exercise. The aim of this study was to evaluate pedometer-determined...
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Activin A and Glucose Derived Human Pancreatic Ductal Cells into Insulin-producing Cells

Hong SH, Han C, Kim HS, Park MK, Lee YJ, Jeong JH, Min YK, Lee MS, Kim KW, Lee MK

BACKGROUND: Cellular replacement therapy holds promise for the treatment of diabetes mellitus but donor tissue is severely limited. Human postnatal pancreatic ductal cells are a potential source of new beta...
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Oxidative Stress Causes Vascular Insulin Resistance in OLETF Rat Through Increased IRS-1 Degradation

Park JL, Lee YS, Kim BH, Kang YH, Kim IJ, Kim YK, Son SM

BACKGROUND: Insulin resistance and oxidative stress have been reported to play essential pathophysiological roles in diabetic cardiovascular complication. The relationship between insulin resistance and oxidative stress in vasculature remains unclear....
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Blood Leptin, Anthropometric and Biochemical Parameters in Type 2 Diabetics

Moon SS, Jeon JH, Lee JE, Park SH, Kim HK, Doh JY, Jung YD, Lee IK, Kim BW, Kim JG

BACKGROUND: Leptin is a hormone which is produced in adipose tissue and regulates food intake and body weight. Leptin is known to correlate with body adiposity such as body mass...
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The Roles of Clusterin on Morphogenesis of Beta Cells During Pancreas Regeneration

Hong SW, Ranjan K, Lee S, Shin YJ, Min BH, Park IS

Clusterin is a highly glycosylated heterodimeric glycoprotein that plays diverse biological roles in various organs. The secreted clusterin has been established as a major form of the protein that exerts...
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Prevention of Diabetes by Fenofibrate in OLETF Rats: Hepatic Mechanism for Reducing Visceral Adiposity

Lee HJ, Park MK, Lee KI, An YJ, Kim JM, Park JY, Han Y, Hong SH, Choi SS, Yoo YH, Suh JD, Kim DK

BACKGROUND: The aim of this study is to evaluate the hepatic mechanism of fenofibrate that has the diabetes protective action in rats. METHODS: We chose OLETF rats and divided them...
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Thiazolidinediones on Insulin Resistance and Insulin Secretion in Obese Diabetic OLETF Rats

Noh JH, Hong SH, Lee KH, Min KM, Yang TY, Lee MS, Kim KW, Lee MK

BACKGROUND: Thiazolidinediones are synthetic peroxisome proliferator-activated receptor-gamma agonists that decrease insulin resistance but, as in vitro and in vivo studies suggest, may have direct beneficial effects on pancreatic beta cells....
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PDX-1/VP16 Overexpression Induce the Transdifferentiation of Canine Adult Pancreatic Cells into Beta-cells

You YH, Park SC, Lee SH, Park HS, Ham DS, Rhee M, Kim JW, Song KH, Yoon KH

BACKGROUND: A major obstacle of islet transplantation is an inadequate supply of insulin-producing tissue. Ad-PDX-1/VP16 overexpression and Exendin-4 treatment have been proved the effects on differentiation and proliferation of pancreatic...
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Glucose-dependent Insulin Secretion from Genetically Engineered K-cells Using EBV-based Episomal Vector

Kim JH, Moon SD, Ko SH, Ahn YB, Song KH, Lim HS, Lee SK, Yoo SJ, Son HS, Yoon KH, Cha BY, Son HY, Kim SJ, Han JH

BACKGROUND: Type 1 diabetes mellitus is an autoimmune disease resulting in destruction of the pancreatic beta cells. Insulin gene therapy for these patients has been vigorously researched. The strategy for...
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