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A Case of Ketosis-Prone Type 2 Diabetes Mellitus

Kim DL, Kim SK, Song KH

Ketosis-prone type 2 diabetes (KPD) has been characterized as diabetes with severe insulin deficiency at diagnosis associated with ketosis or ketoacidosis without a precipitating cause. Improvement in beta-cell function and...
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The Association of Aldose Reductase Gene Polymorphisms with Neuropathy in Patients with Type 2 Diabetes

Jeong IK, Park KS, Moon MK, Kim JH, Shin CS, Kim SY, Lee HK

BACKGROUND: Previous studies have suggested that polymorphisms in and around the aldose reductase (AR) gene are associated with the development of diabetic microvascular disease. This study explored the hypothesis that...
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Mitochondrial Gene Therapy

Ko KS

Mitochondrial dysfunction contributes to a large variety of human disorders, ranging from neurodegenerative and neuromuscular diseases, obesity, and diabetes to ischemia-reperfusion injury and cancer. Increasing pharmacological efforts toward therapeutic interventions...
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The Differences of Circulating Adiponectin Levels and Multimerization According to Obesity in Type 2 Diabetes Mellitus of Men

Chang SA, Son HY, Lee JM, Sohn TS, Kwon HS, Son HS, Yoon KH, Kim HS, Cha BY, Lee KW

BACKGROUND: Adiponectin is adipose tissue derived hormone, which has been shown to play an important role in the regulation of glucose and lipid metabolism. Low adiponectin levels are associated with...
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Changes in the Prevalence of Metabolic Syndrome in a Rural Area of Korea Defined by Two Criteria, Revised National Cholesterol Education Program and International Diabetes Federation

Won JC, Park JY, Song KH, Lee WJ, Koh EH, Nam-Goong , Han SM, Lee MS, Kim MS, Lee KU

BACKGROUND: The prevalence of obesity is increasing in Korea, including rural areas. We examined the changes in the prevalence of metabolic syndrome (MetS), defined by revised National Cholesterol Education Program...
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Effects of Lovastatin on Free Fatty Acid Oxidation in Cultured L6 Rat Skeletal Muscle Cells

Kim DL, Song KH, Kim HR, Kim SK

BACKGROUND: Recent clinical studies suggest that statins improve insulin resistance and glucose metabolism in patients with metabolic syndrome and type 2 diabetes. To evaluate the possible mechanism of this action,...
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Alcohol Consumption, Liver Enzymes, and Prevalence of Metabolic Syndrome in Korean Adult Men

Nam SM, Yu HY, Lee MY, Koh JH, Shin JY, Shin YG, Chung CH

BACKGROUND: Metabolic syndrome is associated with an increasing incidence of diabetes and cardiovascular disease. The relationship between the amount of alcohol consumption and the prevalence of metabolic syndrome is controversial....
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Differentiation of Pancreatic beta Cells from Human Pancreatic Duct Cells Derived from a Partial Pancreas Tissue

Song KH, Kim MM, Lee MK, Ryu GR, Ko SH, Moon SD, Ahn YB, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK, Chin HM

BACKGROUND: Despite a recent breakthrough in human islet transplantation for treating diabetes mellitus, the limited availability of insulin-producing tissue is still a major obstacle. This has led to a search...
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Effects of Troglitazone on the Expression of VEGF and TGF-beta in Cultured Rat Mesangial Cells

Kim DL, Kim NH, Choi DS

BACKGROUND: Clinical study reported that troglitazone ameliorated microalbuminuria in diabetic nephropathy. However, the mechanism of action is not fully understood. Vascular endothelial growth factor (VEGF) is known as vascular permeability...
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Proliferation and Differentiation of Pancreatic beta Cells in L-type Calcium Channel alpha(1D) Subunit (Ca(v)1.3) Heterozygous Knock Out Mice After Partial Pancreatectomy

Choi YH, Yun IH, Suh SH, Lim DJ, Cho JH, Kwon HS, Cha BY, Son HY, Park CG, Yoon KH

BACKGROUNDS: L-type voltage-dependent calcium channel (LTCC) plays a crucial role in insulin secretion from pancreatic beta cells through Ca2+ influx. In the recent report, LTCC Ca(v)1.3 subtype homozygous knock out...
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The Effect of Alpha-lipoic Acid on the Cell Cycle Arrest and Apoptosis in Rat Vascular Smooth Muscle Cells

Kim HJ, Lee IK, Kim YH, Shin SY, Lee YH, Kim JG, Kim BW, Kim HS, Kim MK, Park KG, Ryu SY

BACKGROUND: The proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of atheroscelrosis and post-angioplasty restenosis. We previously showed that alpha-lipoic acid (ALA) inhibited neointimal hyperplasia and has potential...
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Microarray Analysis of Short Heterodimer Partner (SHP)-induced Changes in Gene Expression in INS-1 Cells

Jung ED, Lee JH, Jang WG, Kim JG, Kim BW, Lee IK

BACKGROUND: Nuclear receptors are involved in the cell growth, development, differentiation, and metabolism. The orphan nuclear receptor SHP which lacks a DNA-binding domain is a negative regulator of nuclear receptor...
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Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy

Nam J, Cho MH, Park JS, Lee GT, Kim HJ, Kang ES, Lee YM, Ahn CW, Cha BS, Lee EJ, Lim SK, Kim KR, Ha HJ, Lee HC

BACKGROUND: We evaluated the role of oxidative stress in diabetic nephropathy by measuring intracellular reactive oxygen species (ROS) and redox-sensitive transcription factors in isolated peripheral mononuclear cells (PBMC). METHODS: From...
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