- Intravenous Immunoglobulin Controls Th17 Cell-Mediated Osteoclastogenesis
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Kim KW, Kim HR, Kim BM, Won JY, Lee KA, Lee SH
- KMID: 2455937
- Immune Netw.
- 2019 Aug;19(4):e27.
- doi: 10.4110/in.2019.19.e27
The purpose of this study was to determine the regulatory role of intravenous Ig (IVIg) in Th17 cytokine–induced RANK ligand (RANKL) expression and osteoclast (OC) differentiation from OC precursors (pre-OC).... -
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- Optimization of Cytokine Milieu to Reproduce Atopic Dermatitis-related Gene Expression in HaCaT Keratinocyte Cell Line
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Kim HJ, Baek J, Lee JR, Roh JY, Jung Y
- KMID: 2410159
- Immune Netw.
- 2018 Apr;18(2):e9.
- doi: 10.4110/in.2018.18.e9
Although atopic dermatitis (AD) is characterized by cytokine production predominantly mediated by T helper (Th) 2 cells, AD pathogenesis also involves innate immune and Th1 cells. To optimize the cytokine... -
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- T-Helper Type 2 Cells Direct Antigen-Induced Eosinophilic Skin Inflammation in Mice
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Kaminuma O, Nishimura , Kitamura N, Saeki M, Hiroi T, Mori A
- KMID: 2428852
- Allergy Asthma Immunol Res.
- 2018 Jan;10(1):77-82.
- doi: 10.4168/aair.2018.10.1.77
Eosinophilic inflammation in combination with immunoglobulin E (IgE) production is a characteristic feature of atopic dermatitis. Although activated T-helper type (Th) 2 cells play critical roles in the local accumulation... -
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- Serosal Cavities Contain Two Populations of Innate-like integrin α4highCD4+ T Cells, Integrin α4β1+α6β1+α4β7− and α4β1+α6β1−α4β7+ Cells
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Yang JI, Park C, Kho I, Lee S, Suh KS, Kim TJ
- KMID: 2400625
- Immune Netw.
- 2017 Dec;17(6):392-401.
- doi: 10.4110/in.2017.17.6.392
We previously reported peritoneal innate-like integrin α4 (CD49d)highCD4+ T cells that provided help for B-1a cells. Here we analyzed the expression of various integrin chains on the peritoneal and pleural... -
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- Mycobacterium vaccae induces a strong Th1 response that subsequently declines in C57BL/6 mice
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Zhang L, Jiang Y, Cui Z, Yang W, Yue L, Ma Y, Shi S, Wang C, Wang C, Qian A
- KMID: 2412606
- J Vet Sci.
- 2016 Dec;17(4):505-513.
- doi: 10.4142/jvs.2016.17.4.505
Mycobacterium (M.) vaccae is a fast-growing species of saprophytic bacteria that is widely distributed. To understand the host immune responses induced by M. vaccae isolated from bovine submaxillary lymph nodes,... -
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- CpG Oligodeoxynucleotide Inhibits Cockroach-Induced Asthma via Induction of IFN-gamma+ Th1 Cells or Foxp3+ Regulatory T Cells in the Lung
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Kim DH, Sohn JH, Park HJ, Lee JH, Park JW, Choi JM
- KMID: 2391047
- Allergy Asthma Immunol Res.
- 2016 May;8(3):264-275.
- doi: 10.4168/aair.2016.8.3.264
PURPOSE: CpG oligodeoxynucleotide (CpG-ODN), a TLR9 agonist, activates innate immunity and induces Th1 response. Although the immune modulatory effect of CpG-ODN has been extensively studied, its function in cockroach extract-induced... -
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- Regulation of Th2 Cell Immunity by Dendritic Cells
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Na H, Cho M, Chung Y
- KMID: 2154806
- Immune Netw.
- 2016 Feb;16(1):1-12.
- doi: 10.4110/in.2016.16.1.1
Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which... -
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- Anti-proliferative Activity of T-bet
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Oh YJ, Shin JH, Won HY, Hwang ES
- KMID: 2168047
- Immune Netw.
- 2015 Aug;15(4):199-205.
- doi: 10.4110/in.2015.15.4.199
T-bet is a critical transcription factor that regulates differentiation of Th1 cells from CD4+ precursor cells. Since T-bet directly binds to the promoter of the IFN-gamma gene and activates its... -
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- Modulation of Antibody Responses against Gnathostoma spinigerum in Mice Immunized with Crude Antigen Formulated in CpG Oligonucleotide and Montanide ISA720
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Intapan PM, Hirunpetcharat C, Kularbkaew C, Yutanawiboonchai W, Janwan P, Maleewong
- KMID: 1712215
- Korean J Parasitol.
- 2013 Dec;51(6):637-644.
- doi: 10.3347/kjp.2013.51.6.637
This study aimed to investigate the antibody responses in mice immunized with Gnathostoma spinigerum crude antigen (GsAg) incorporated with the combined adjuvant, a synthetic oligonucleotide containing unmethylated CpG motif (CpG... -
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- Therapeutic Effects and Immunomodulation of Suanbo Mineral Water Therapy in a Murine Model of Atopic Dermatitis
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Choi YJ, Lee HJ, Lee DH, Woo SY, Lee KH, Yun ST, Kim JM, Kim HJ, Kim JW
- KMID: 2265057
- Ann Dermatol.
- 2013 Nov;25(4):462-470.
- doi: 10.5021/ad.2013.25.4.462
BACKGROUND: Balneotherapy is widely used as an alternative treatment modality for AD. Although the clinical benefit of some mineral waters has been established, their mechanisms of action in alleviating AD... -
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- Alteration of Cytokine Production during Visceral Larva Migrans by Toxascaris leonina in Mice
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Kang SA, Park MK, Cho MK, Yu HS
- KMID: 1792153
- Korean J Parasitol.
- 2013 Oct;51(5):583-588.
To determine alteration of immune responses during visceral larva migrans (VLM) caused by Toxascaris leonina at several time points, we experimentally infected mice with embryonated eggs of T. leonina and... -
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- Clinical efficacy and mechanism of probiotics in allergic diseases
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Kim HJ, Kim HY, Lee SY, Seo JH, Lee E, Hong SJ
- KMID: 1493117
- Korean J Pediatr.
- 2013 Sep;56(9):369-376.
- doi: 10.3345/kjp.2013.56.9.369
A complex interplay between genetic and environmental factors partially contributes to the development of allergic diseases by affecting development during prenatal and early life. To explain the dramatic increase in... -
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- Elevated Levels of T Helper 17 Cells Are Associated with Disease Activity in Patients with Rheumatoid Arthritis
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Kim J, Kang S, Kim J, Kwon G, Koo S
- KMID: 1781298
- Ann Lab Med.
- 2013 Jan;33(1):52-59.
- doi: 10.3343/alm.2013.33.1.52
BACKGROUND: Interleukin-17 (IL-17)-producing T helper (Th) 17 cells are considered as a new subset of cells critical to the development of rheumatoid arthritis (RA). We aimed to investigate the distribution... -
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- Mechanism of experimental autoimmune encephalomyelitis in Lewis rats: recent insights from macrophages
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Shin T, Ahn M, Matsumoto
- KMID: 2046740
- Anat Cell Biol.
- 2012 Sep;45(3):141-148.
- doi: 10.5115/acb.2012.45.3.141
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is an acute monophasic paralytic central nervous system disease, in which most rats spontaneously recover from paralysis. EAE in Lewis rats is induced... -
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- Th17 Responses Are Not Induced in Dextran Sodium Sulfate Model of Acute Colitis
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Kim YS, Lee MH, Ju AS, Rhee KJ
- KMID: 2150729
- Immune Netw.
- 2011 Dec;11(6):416-419.
- doi: 10.4110/in.2011.11.6.416
Dextran sodium sulfate (DSS) is a widely used chemical model for inflammatory bowel disease (IBD). It is thought that imbalances in the T helper (Th) cell subsets contribute to IBD.... -
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- Identification of CCL1 as a Gene Differentially Expressed in CD4+ T Cells Expressing TIM-3
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Jun KJ, Lee MJ, Shin DC, Woo MY, Kim K, Park S
- KMID: 1449811
- Immune Netw.
- 2011 Aug;11(4):203-209.
- doi: 10.4110/in.2011.11.4.203
BACKGROUND: T cell immunoglobulin mucin containing molecule (TIM)-3 is expressed in differentiated Th1 cells and is involved in the suppression of the cytokine production by these cells. However, the regulation... -
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- IL-33 and Airway Inflammation
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Oboki K, Nakae S, Matsumoto , Saito H
- KMID: 2130358
- Allergy Asthma Immunol Res.
- 2011 Apr;3(2):81-88.
- doi: 10.4168/aair.2011.3.2.81
Interleukin-33 (IL-33) is the 11th member of IL-1 cytokine family which includes IL-1 and IL-18. Unlike IL-1beta and IL-18, IL-33 is suggested to function as an alarmin that is released... -
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- Regulation and Function of Th17 Cells
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- KMID: 2090204
- Korean J Asthma Allergy Clin Immunol.
- 2011 Mar;31(1):1-8.
Naive CD4+ helper T (Th) cells, upon activation by antigen-presenting cells (APC), differentiate into different types of effecter cells that are characterized by their distinct cytokine production profiles and immune... -
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- Genetic controls of Th17 cell differentiation and plasticity
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Dong C
- KMID: 991617
- Exp Mol Med.
- 2011 Jan;43(1):1-6.
- doi: 10.3858/emm.2011.43.1.007
CD4+ T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naive T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2... -
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- Associations between TBX21 Gene Polymorphisms and Korean Patients with Behcet's Disease
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Hwang JH, Song JK, Yoo IS, Song ST, Kim JH, Lee YJ, Bae YD, Choi HJ, Baek HJ, Kang SW
- KMID: 2201893
- J Korean Rheum Assoc.
- 2010 Dec;17(4):360-367.
- doi: 10.4078/jkra.2010.17.4.360
OBJECTIVE: Behcet's disease (BD) is a chronic systemic inflammatory disease with unknown etiology. A number of clinical and laboratory findings suggest a strongly polarized Th1 immune response in BD. T-bet... -
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