- Telomerase Activity and Expression of Telomerase RNA in Malignant Fibrous Histiocytoma
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Yoo J, Kang SJ, Kim BK
- KMID: 2011743
- Korean J Pathol.
- 2000 Aug;34(8):581-587.
Telomerase is an RNA-dependent DNA polymerase that synthesizes TTAGGG telomeric DNA onto chromosomal ends to compensate for sequence loss during replication. It has been detected in a variety of human... -
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- Extracting Extra-Telomeric Phenotypes from Telomerase Mouse Models
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Sung YH, Ali M, Lee HW
- KMID: 1779879
- Yonsei Med J.
- 2014 Jan;55(1):1-8.
- doi: 10.3349/ymj.2014.55.1.1
Telomerase reverse transcriptase (TERT) is the protein component of telomerase and combined with an RNA molecule, telomerase RNA component, forms the telomerase enzyme responsible for telomere elongation. Telomerase is essential... -
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- Mouse models for telomere and telomerase biology
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Cheong C, Hong KU, Lee HW
- KMID: 1094694
- Exp Mol Med.
- 2003 Jun;35(3):141-153.
Telomeres serve a critical role in maintenance of genomic stability in all eukaryotes, from yeast to human. The maintenance of telomeres is achieved by the telomerase complex, which is largely... -
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- Telomerase Activity and Expression of hTR and TERT in Human Soft Tissue Sarcomas
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Yoo J, Kang SJ, Kim BK
- KMID: 1972968
- Cancer Res Treat.
- 2002 Feb;34(1):46-51.
PURPOSE: Sarcomas have rarely been analyzed for telomerase, which is an RNA-dependent DNA polymerase to maintain telomeres and prevent telomere shortening. This study was undertaken to determine telomerase activity and... -
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- Telomerase activity in pterygeal and normal conjunctival epithelium
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Park TK, Jin KH
- KMID: 754280
- Korean J Ophthalmol.
- 2000 Dec;14(2):85-89.
- doi: 10.3341/kjo.2000.14.2.85
All pterygia have similar histologic features of solar degeneration seen in the skin such as acanthosis, keratosis, or hyperkeratosis. Although the pathogenesis of pterygia is still unclear, an association with... -
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- Detection of Telomerase Activity in Psoriasis Lesional Skin and Correlaton with Ki-67 Expression and Suppression by Retinoic Acid
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Jang HS, Oh CK, Jo JH, Kim YS, Kwon KS
- KMID: 2157573
- J Korean Med Sci.
- 2001 Oct;16(5):623-629.
- doi: 10.3346/jkms.2001.16.5.623
Telomerase activity is usually detected in most tumor tissues but not in normal tissues. Recently, there is increasing evidence that telomerase activity is associated with cell proliferation without malignancy, whereas... -
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- The Relationship between Telomerase Activation and Helicobacter pylori Infection in Gastric Cancer
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Kang SS, Jang HJ, Kim JH, Eun CS, Kae SH, Lee J
- KMID: 2306083
- Korean J Med.
- 2002 Dec;63(6):634-642.
BACKGROUND: Telomerase, an enzyme synthesizing telomere, plays an important role in cell immortalization and carcinogenesis. Telomerase activity is detected in large number of malignant tumors and also in precancerous lesions,... -
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- The Changes of Telomerase Activity and Proliferating Cell Nuclear Antigen (PCNA) Expression in the Developmental Stages of Rat Kidney
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Oh GS, Lee SD
- KMID: 1583581
- Korean J Urol.
- 2000 Sep;41(9):1041-1050.
No abstract available. -
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- Telomerase Activity in Endometrium According to Menstrual Cycle
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Lee HY, Koh MW
- KMID: 2269860
- Korean J Obstet Gynecol.
- 1999 Sep;42(9):1948-1954.
OBJECTIVE: Recently, telomerase activity was found in normal physiologically regenerating cells as well as cancer cells or germ cells. Human endometrium is also physiologically regenerating tissues and undergoes regular and... -
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- Telomerase Activity in Gestational Trophoblastic Disease
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Bae SN, Jung JK, Choi EA, Kim JS, Kim DJ, Ahn HY, Kim SJ
- KMID: 2269580
- Korean J Obstet Gynecol.
- 1998 Jun;41(6):1704-1708.
The purpose of this study was to evaluate the significance of telomerase activity in gestational trophoblastic disease and the association of telomerase activity in complete hydatidiform mole and subsequent development... -
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- Relationship between Clinicopathological Characteristics and Telomerase Activity of Renal Cell Carcinoma
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Chung JM, Lee SD, Chung MK, Jun ES
- KMID: 2293328
- Korean J Urol.
- 2003 May;44(5):403-408.
PURPOSE: Telomerase is a ribonucleoprotein involved in maintaining the telomere length in stem, and immortal or actively dividing, cells. There is controversy relating to the correlation between the telomerase activity... -
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- Difference of Telomerase Activity Between Uterine Cervical Intraepithelial Neoplasia, Early and Advanced Cervical Cancers
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Kim J, Lee JB, Seo YS, Nam SL
- KMID: 2261551
- Korean J Obstet Gynecol.
- 1999 Oct;42(10):2293-2299.
OBJECTIVES: Objective: Cellular immortality is believed to be a critical step in tumorigenesis. As an important component of the telomere maintenance mechanism, the activation of the enzyme telomerase is tightly... -
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- Telomerase Activity is Constitutively Expressed in the Murine CD8+ T Cells and Controlled Transcriptionally and Post-Translationally
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Kim S, Kim M, Kim K
- KMID: 2167978
- Immune Netw.
- 2004 Sep;4(3):166-175.
- doi: 10.4110/in.2004.4.3.166
BACKGROUND: Telomerase, a ribonucleoprotein enzyme capable of synthesizing telomeric repeats, attracts attention for its possible role in determining the replicative capacity of normal somatic cells, transformed cells, and cells of... -
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- Relationship between the Telomerase Activation and Helicobacter pylori Infection in Benign and Precancerous Lesion of the Stomach
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Jang HJ, Kim JH, Hong SJ, Kang SS, Kae SH, Lee J, Joo SA
- KMID: 1864931
- Korean J Gastroenterol.
- 2001 Jul;38(1):15-22.
BACKGROUND/AIMS: Telomerase activity has been detected not only in human cancers but also in precancerous lesion (e.g., intestinal metaplasia). It suggests that telomerase activation may be an early event in... -
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- Telomerase PCR-ELISA Assay in Diagnosis of Bladder Tumor
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Lee SJ, Lee WI, Chang SG
- KMID: 2289964
- Korean J Urol.
- 1999 Mar;40(3):322-326.
PURPOSE: The detection of telomerase activity is a new and useful method in diagnosis of bladder transitional cell carcinoma(TCC) in urine samples. But the detection method of telomerase activity is... -
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- Telomerase activity in benign and malignant human thyroid nodules
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Ahn MJ, Tae K, Park YS, Kim IS, Choi IY, Lee HS, Kim SK, Lee YS
- KMID: 2052791
- Exp Mol Med.
- 1997 Sep;29(3):157-160.
Telomerase is a ribonucleoprotein polymerase which contains an integral RNA and synthesizes TTAGGG nucleotide repeats at the ends of chromosomes in vertebrates. Accumulated evidence has indicated that telomerase is stringently... -
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- Telomerase Activity in Rheumatoid Arthritis
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Koh HK, Ahn MJ, Kim TH, Lee EY, Yoo TS, Lee JK, Chang DK, Shim SC, Jun JB, Jung SS, Lee IH, Bae SC, Yoo DH, Choi YK, Kim SY
- KMID: 1544916
- J Korean Rheum Assoc.
- 1999 Mar;6(1):6-13.
No abstract available. -
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- Telomerase Activity in Primary Lung Cancers
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Yun SM, Kwak KR, Hwang JY, Park SS, Jeon DS, Kim CM, Lee MK, Park SK
- KMID: 2009793
- Tuberc Respir Dis.
- 1999 Feb;46(2):195-203.
- doi: 10.4046/trd.1999.46.2.195
BACKGROUND: Telomerase enzyme activity is not detected in most normal cells, a phonomenon believed to be associated with limitations on cellular proliferation. Since this activity is detected in nearly all... -
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- Effect of Bcl-2 Expression and Telomerase Activity on Apoptosis of the Brain Tumors
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Kim CH, Cheong JH, Bak KH, Kim JM, Ko Y, Oh SJ
- KMID: 2188830
- J Korean Neurosurg Soc.
- 2002 Jul;32(1):35-41.
OBJECTIVE: The regulation of apoptosis is influenced by various gene products including Bcl-2, which has been known to be anti-apoptotic. In addition, telomerase, a ribonucleoprotein that synthesizes telomeres, has been... -
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- Diagnostic Significance of Telomerase Activity in Breast Cancer
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Park WC, Jung SS, Kim IC
- KMID: 2209283
- J Korean Surg Soc.
- 2000 Jun;58(6):767-774.
PURPOSE: This study was performed to confirm the differences in telomerase activities between breast cancer and benign breast disease and to evaluate the clinical significance of telomerase activity in the... -
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