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Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS

Leem YH, Park JS, Park JE, Kim DY, Kim HS

Microglial priming is the process of microglial proliferation and activation in response to neurodegeneration and abnormal protein accumulation. Priming makes microglia susceptible to secondary inflammatory stimuli and causes exaggerated inflammatory...
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High Systemic Inflammation Response Index (SIRI) Indicates Poor Outcome in Gallbladder Cancer Patients with Surgical Resection: A Single Institution Experience in China

Sun L, Hu W, Liu M, Chen Y, Jin B, Xu H, Du S, Xu Y, Zhao H, Lu X, Sang X, Zhong S, Yang H, Mao Y

Purpose The systemic inflammation response index (SIRI) has been reported to have prognostic ability in various solid tumors but has not been studied in gallbladder cancer (GBC). We aimed to determine...
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Left ventricular dysfunction in relation with systemic inflammation in chronic obstructive pulmonary disease patients

Gulen ST, Eryilmaz U, Yilmaz M, Karadag F

BACKGROUND/AIMS: Most important cause of mortality in chronic obstructive pulmonary disease (COPD) patients is known to be cardiovascular disease (CVD). The objective of the present study was to evaluate the...
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Breakthrough in heart failure with preserved ejection fraction: are we there yet?

Lim SL, Lam CS

Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective...
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The Utility of Serum Procalcitonin Levels in the Management of Systemic Inflammatory Response Syndrome in the Emergency Department

Park KH, Lee KH, Cha KC, Kim H, Hwang SO

BACKGROUND: The aim of this study was to investigate whether obtaining serum procalcitonin (PCT) levels in patients with systemic inflammatory response syndrome (SIRS) helps the differential diagnosis between sepsis and...
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Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra

Jeong HK, Jou I, Joe EH

It has been suggested that brain inflammation is important in aggravation of brain damage and/or that inflammation causes neurodegenerative diseases including Parkinson's disease (PD). Recently, systemic inflammation has also emerged...
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Metabolic Syndrome, Insulin Resistance and Systemic Inflammation as Risk Factors for Reduced Lung Function in Korean Nonsmoking Males

Lim SY, Rhee EJ, Sung KC

The aim of this study was done to assess the association of lung function with insulin resistance (IR), systemic inflammation, and metabolic syndrome (MetS). In 9,581 apparently healthy non-smoking male...
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The Relationship between Reduced Lung Function and High Sensitive C-reactive Protein in Healthy Adult Men

Lee JU, Paek YJ

  • KMID: 2056499
  • J Korean Acad Fam Med.
  • 2007 Nov;28(11):860-866.
BACKGROUND: Increased levels of systemic markers of inflammation have been reported in patients with impaired lung function with obstructive and restrictive lung diseases. We hypothesized that forced expiratory volume in...
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