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Case 9: A 62-Year-Old Woman With Jaundice and General Weakness

Cho HS, Han JW, Kim JH, Nam H, Sung PS, Bae SH

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Targetoid Primary Liver Malignancy in Chronic Liver Disease: Prediction of Postoperative Survival Using Preoperative MRI Findings and Clinical Factors

Park SH, Heo S, Kim B, Lee J, Choi HJ, Sung PS, Choi JI

Objective: We aimed to assess and validate the radiologic and clinical factors that were associated with recurrence and survival after curative surgery for heterogeneous targetoid primary liver malignancies in patients...
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Identification and comparison of functional microbiomes affecting immune homeostasis in long-term stable and tolerant patients after liver transplantation

Lee SK, Jhun JY, Cho ML, Choi HJ, You YK, Sung PS, Jang JW, Yoon SK, Choi JY

Background: In this study, we aimed to identify the gut microbial balance and functional microbiomes affecting immune homeostasis in the long-term post-liver transplant (LT) and tolerant patients. Methods: A total of...
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Real-life experience of ledipasvir and sofosbuvir for HCV infected Korean patients: a multicenter cohort study

Lee SK, Lee SW, Lee HL, Kim HY, Kim CW, Song DS, Chang UI, Yang JM, Yoo SH, Kwon JH, Nam SW, Kim SH, Song MJ, Lee J, Yang H, Bae SH, Han JW, Nam H, Sung PS, Jang JW, Choi JY, Yoon SK

Background/Aims: To evaluate the efficacy and safety of ledipasvir/sofosbuvir (LDV/SOF) therapy in hepatitis C virus (HCV)-infected Korean patients in a real clinical setting. Methods: A total of 273 patients who received...
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Autoimmune liver disease represented as primary biliary cholangitis after SARS-CoV-2 infection: A need for population-based cohort study

Lee SK, Kwon JH, Yoon N, Nam SW, Sung PS

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Multidisciplinary approach for hepatocellular carcinoma arising from cirrhotic liver with Budd-Chiari syndrome: a case report

Kim S, Kim JH, Han JW, Jang JW, Choi JY, Yoon SK, Sung PS

Budd-Chiari syndrome (BCS) is defined by the obstruction of the hepatic venous outflow between the small hepatic veins and the junction of the inferior vena cava (IVC) with the right...
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Safety and effectiveness of direct-acting antivirals in patients with chronic hepatitis C and chronic kidney disease

Ryu JE, Song MJ, Kim SH, Kwon JH, Yoo SH, Nam SW, Nam HC, Kim HY, Kim CW, Yang H, Bae SH, Song DS, Chang UI, Yang JM, Lee SW, Lee HL, Lee SK, Sung PS, Jang JW, Choi JY, Yoon SK

Background/Aims: To evaluate the effectiveness and safety of direct acting antivirals (DAAs) available in chronic kidney disease (CKD) patients with hepatitis C virus (HCV) infection in Korea. Methods: In a retrospective,...
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Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases

Lee HA, Chang Y, Sung PS, Yoon EL, Lee HW, Yoo JJ, Lee YS, An J, Song DS, Cho YY, Kim SU, Kim YJ

The global burden of chronic liver disease (CLD) is substantial. Due to the limited indication of and accessibility to antiviral therapy in viral hepatitis and lack of effective pharmacological treatment...
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Crosstalk between tumor-associated macrophages and neighboring cells in hepatocellular carcinoma

Sung PS

The tumor microenvironment generally shows a substantial immunosuppressive activity in hepatocellular carcinoma (HCC), accounting for the suboptimal efficacy of immune-based treatments for this difficult-to-treat cancer. The crosstalk between tumor cells...
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Diagnostic performance of serum exosomal miRNA-720 in hepatocellular carcinoma

Jang JW, Kim JM, Kim HS, Kim JS, Han JW, Lee SK, Nam H, Sung PS, Bae SH, Choi JY, Yoon SK

Background/Aim: Hepatocellular carcinoma (HCC) is associated with poor prognosis, largely due to late detection. Highly accurate biomarkers are urgently needed to detect early-stage HCC. Our study aims to explore the...
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Anti-fibrotic effects of branched-chain amino acids on hepatic stellate cells

Lee HL, Lee J, Cha JH, Cho S, Sung PS, Hur W, Yoon SK, Bae SH

Background/Aims: Patients with liver cirrhosis (LC) have low levels of branchedchain amino acids (BCAAs). There is accumulating evidence that BCAAs have anti- fibrotic effects in cirrhosis. This study is aimed...
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Simple but Organized Neurology Residency Training Improves the Quality of Acute Stroke Care: From the Outset to Long-Term Effect

Chang YM, Wang CM, Lin PY, Sung PS, Lin SH, Chen CH

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Targeted Next-Generation Sequencing of Plasma CellFree DNA in Korean Patients with Hepatocellular Carcinoma

Chae H, Sung PS, Choi H, Kwon A, Kang D, Kim Y, Kim M, Yoon SK

Background: Hepatocellular carcinoma (HCC) is the second-most-common cause of cancer-related deaths worldwide, and an accurate and non-invasive biomarker for the early detection and monitoring of HCC is required. We assessed...
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Persistence of intrahepatic hepatitis B virus DNA integration in patients developing hepatocellular carcinoma after hepatitis B surface antigen seroclearance

Jang JW, Kim JS, Kim HS, Tak KY, Nam H, Sung PS, Bae SH, Choi JY, Yoon SK, Roberts LR

Background/Aims: The role of hepatitis B virus (HBV) integration into the host genome in hepatocarcinogenesis following hepatitis B surface antigen (HBsAg) seroclearance remains unknown. Our study aimed to investigate and...
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Infiltration of T Cells and Programmed Cell Death Ligand 1-expressing Macrophages as a Potential Predictor of Lenvatinib Response in Hepatocellular Carcinoma

Sung PS, Cho SW, Lee J, Yang H, Jang JW, Bae SH, Choi JY, Yoon SK

Background/Aims: Lenvatinib was recently proven to be non-inferior to sorafenib in treating unresectable hepatocellular carcinoma (HCC) in a phase-3 randomized controlled trial. In this study, we investigated whether the response...
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Maintenance of Stroke Care Quality amid the Coronavirus Disease 2019 Outbreak in Taiwan

Chen CH, Liu CH, Chi NF, Sung PS, Hsieh CY, Lee M, Tang SC, Jeng JS, on Behalf of the Taiwan Stroke Society Investigators

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Management of Hyperacute Stroke during the Coronavirus Disease of 2019 Pandemic: The Modified Code Stroke in a Medical Center in Taiwan

Lin PY, Chang YM, Huang CY, Lin CH, Chuang MT, Chen PL, Sung PS, Chen CH

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Solitary fibrous tumor of the liver mimicking malignancy

Nam HC, Sung PS, Jung ES, Yoon SK

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Successful Sequential Therapy Involving Regorafenib after Failure of Sorafenib in a Patient with Recurrent Hepatocellular Carcinoma after Liver Transplantation

Lee SK, Jang JW, Nam H, Sung PS, Bae SH, Choi JY, Yoon SK

The efficacy and safety of sequential systemic therapy for the treatment of recurrent hepatocellular carcinoma (HCC) after liver transplantation (LT) are not well established. This study describes a successful experience...
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A different detection method reveals a new role of alanine aminotransferase as an indicator of liver fibrosis

Sung PS

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