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Regional Comparison of Imaging Biomarkers in the Striatum between Early- and Late-onset Alzheimer’s Disease

Kim JE, Lee DK, Hwang JH, Kim CM, Kim Y, Lee JH, Lee JM, Roh JH, ADNI(

  • KMID: 2537959
  • Exp Neurobiol.
  • 2022 Dec;31(6):401-408.
  • doi: 10.5607/en22022
Striatal changes in the pathogenesis of Alzheimer’s disease (AD) is not fully understood yet. We compared structural and functional image differences in the striatum between patients with early onset AD...
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Quantitative Sequencing Analysis of the Striatal Transcriptome in a Mouse Model of Alzheimer Disease

Kim TK, Lee S, Im HI

Purpose: The purpose of this study was to analyze the transcriptomic changes in the striatum of amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice and uncover its association with the methyl-CpG...
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Striatal ZBTB16 Is Associated With Cognitive Deficits in Alzheimer Disease Mice

Lee S, Kim TK, Choi JE, Kim HS, Im HI

Purpose: In Alzheimer disease (AD), brain regions such as the cortex and the hippocampus show abundant amyloid load which correlates with cognitive function decline. Prior to the significant development of...
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Antimicrobial Susceptibility Patterns and Clinical Characteristics of Corynebacterium striatum Cases from 2018 to 2021

Choi I, Lee Y

Background: Corynebacterium striatum is part of the normal flora of the skin, oral cavity, and intestine. However, it can be a pathogen causing endocarditis, pneumonia, arthritis, and meningitis occasionally. We...
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Generation of Astrocyte-Specific MAOB Conditional Knockout Mouse with Minimal Tonic GABA Inhibition

Lee JM, Sa M, An H, Kim JMJ, Kwon J, Yoon BE, Lee CJ

  • KMID: 2531119
  • Exp Neurobiol.
  • 2022 Jun;31(3):158-172.
  • doi: 10.5607/en22016
Monoamine oxidase B (MAOB) is a key enzyme for GABA production in astrocytes in several brain regions. To date, the role of astrocytic MAOB has been studied in MAOB null...
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Septic Knee Arthritis Caused by Corynebacterium striatum

Park SH, Yoon HK, Kim H, Choi HJ

Corynebacterium striatum (C. striatum ) is an aerobic Gram-positive rod, which is an organism of the respiratory tract and skin. Because of its low virulence, it is usually thought to...
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Interleukin 13 on Microglia is Neurotoxic in Lipopolysaccharide-injected Striatum in vivo

Hong AR, Jang JG, Chung YC, Won SY, Jin BK

To explore the potential function of interleukin-13 (IL-13), lipopolysaccharide (LPS) or PBS as a control was unilaterally microinjected into striatum of rat brain. Seven days after LPS injection, there was...
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Implications of Adult Neural Stem Cell Abnormalities in the Pathophysiological Mechanism of Schizophrenia

Kim Y

Schizophrenia is a syndrome involving positive symptoms, negative symptoms, and cognitive decline due to several causes. The neuropathological findings of schizophrenia are unclear, but the age of onset of schizophrenia...
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Neural Mechanisms in Eating Behaviors: A Pilot fMRI Study of Emotional Processing

Molina-Ruiz RM, García-Saiz T, Looi JC, Via Virgili E, Rincón Zamorano M, de Anta Tejado L, López HT, Perera JLC, Díaz-Marsá M

Objective Emotional processing dysfunction evident in eating disorders (ED) such as anorexia nervosa (AN) and bulimia nervosa (BN), is considered relevant to the development and maintenance of these disorders. The...
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Age-related Effects of Heroin on Gene Expression in the Hippocampus and Striatum of Cynomolgus Monkeys

Choi MR, Jin YB, Bang SH, Im CN, Lee Y, Kim HN, Chang KT, Lee SR, Kim DJ

Objective: The aim of this study was to investigate differentially expressed genes and their functions in the hippocampus and striatum after heroin administration in cynomolgus macaques of different ages. Methods: Cynomolgus...
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Functional Connectivity of the Striatum as a Neural Correlate of Symptom Severity in Patient with Obsessive-Compulsive Disorder

Park J, Kim T, Kim M, Lee TY, Kwon JS

Objective It is well established that the cortico-striato-thalamo-cortical (CSTC) circuit is implicated in the pathophysiology of obsessive- compulsive disorder (OCD). However, reports on corticostriatal functional connectivity (FC) in OCD have...
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Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum

Lee Y, Han PL

A number of specific genetic variants including gene mutations and single nucleotide variations have been identified in genomewide association studies of autism spectrum disorder (ASD). ASD phenotypes in individuals carrying...
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Striatal Inhibition of MeCP2 or TSC1 Produces Sociability Deficits and Repetitive Behaviors

Lee Y, Kim H, Han PL

Autism spectrum disorder (ASD) is a heterogeneous group of neurobehavioral disorders characterized by the two core domains of behavioral deficits, including sociability deficits and stereotyped repetitive behaviors. It is not...
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Dysfunctional Social Reinforcement Processing in Disruptive Behavior Disorders: An Functional Magnetic Resonance Imaging Study

Hwang S, Meffert H, VanTieghem MR, Sinclair S, Bookheimer SY, Vaughan B, Blair RJ

OBJECTIVE: Prior functional magnetic resonance imaging (fMRI) work has revealed that children/adolescents with disruptive behavior disorders (DBDs) show dysfunctional reward/non-reward processing of non-social reinforcements in the context of instrumental learning...
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Microbiological Characteristics of Corynebacterium striatum, an Emerging Pathogen

Song SA, Shin JH

C. striatum is part of the normal skin and mucous membrane flora in humans and is widely disseminated in the environment. Traditionally, these strains have been considered contaminants. However, C....
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A Case of Type III Hyperlipoproteinemia Accompanied by Xanthoma Striatum Palmare

Kim HJ, Seo JW, Kim TH, Choi SH, Kim KH

  • KMID: 2436667
  • Korean J Dermatol.
  • 2018 Mar;56(3):187-191.
Xanthomas are localized lipid deposits within organs that may manifest as papules, plaques, or nodules in skin. They are commonly associated with all types of hyperlipidemia. Xanthoma striatum palmare characterized...
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A Case Report of a 37-Year-Old Alzheimer's Disease Patient with Prominent Striatum Amyloid Retention

Um YH, Choi WH, Jung WS, Park YH, Lee CU, Lim HK

With recent advancement in amyloid imaging, diagnostic application of this new modality has become a great interest among researchers. New ligands, such as 18F- florbetaben, florbetapir and flutemetamol, have been...
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The Putamen and Caudate Nucleus Volume in Korean Youth by MRI Volumetry

Cho SH, Kwon S, Rhyu IJ

Corpus striatum is subcortical nuclei composed of caudate nucleus and putamen. It has been considered to be associated with motor control and learning. Dysfunction of the striatum is related to...
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Neuroprotective effect of caffeic acid phenethyl ester in 3-nitropropionic acid-induced striatal neurotoxicity

Bak J, Kim HJ, Kim SY, Choi YS

Caffeic acid phenethyl ester (CAPE), derived from honeybee hives, is a bioactive compound with strong antioxidant activity. This study was designed to test the neuroprotective effect of CAPE in 3-nitropropionic...
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Reversal of an Unconditioned Behavioral Preference for Specific Food Pellets by Intervention of Whisker Sensory Inputs

Kim H, Lee Y, Kim JE, Han PL

Adenylyl cyclase type-5 (AC5) is preferentially expressed in the dorsal striatum. Recently, we reported that AC5 knockout (KO) mice preferred food pellets carrying an olfactory cue produced by AC5 KO...
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