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XperCT-guided Intra-cisterna Magna Injection of Streptozotocin for Establishing an Alzheimer’s Disease Model Using the Cynomolgus Monkey (Macaca fascicularis)

Park J, Won J, Jeon CY, Lim KS, Choi WS, Park Sh, Seo J, Cho J, Seong JB, Yeo HG, Kim K, Kim YG, Kim M, Yi KS, Lee Y

  • KMID: 2537960
  • Exp Neurobiol.
  • 2022 Dec;31(6):409-418.
  • doi: 10.5607/en22027
Till date, researchers have been developing animal models of Alzheimer’s disease (AD) in various species to understand the pathological characterization and molecular mechanistic pathways associated with this condition in humans...
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Peripheral Neuropathy Phenotyping in Rat Models of Type 2 Diabetes Mellitus: Evaluating Uptake of the Neurodiab Guidelines and Identifying Future Directions

Hossain MJ, Kendig MD, Letton ME, Morris MJ, Arnold R

Diabetic peripheral neuropathy (DPN) affects over half of type 2 diabetes mellitus (T2DM) patients, with an urgent need for effective pharmacotherapies. While many rat and mouse models of T2DM exist,...
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Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect

Chang XM, Xiao F, Pan Q, Wang XX, Guo LX

Although the contributions of sitagliptin to endothelial dysfunction in diabetes mellitus were previously reported, the mechanisms still undefined. Autophagy plays an important role in the development of diabetes mellitus, but...
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Experimental animal models for diabetes and its related complications—a review

Kottaisamy CPD, Raj DS, Kumar VP, Sankaran U

Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition...
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Effects of Diabetes Mellitus on the Disposition of Tofacitinib, a Janus Kinase Inhibitor, in Rats

Gwak EH, Yoo HY, Kim SH

Tofacitinib, a Janus kinase inhibitor, was developed for the treatment of rheumatoid arthritis. Recently, it has been associated with an increased change in arthritis development in patients with diabetes. Herein,...
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Synaptic loss and amyloid beta alterations in the rodent hippocampus induced by streptozotocin injection into the cisterna magna

Ahn Y, Seo J, Park J, Won J, Yeo HG, Kim K, Jeon CY, Huh JW, Lee SR, Lee DS, Lee Y

To date, researchers have developed various animal models of Alzheimer’s disease (AD) to investigate its mechanisms and to identify potential therapeutic treatments. A widely recognized model that mimics the pathology...
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The effects of Commiphora mukul extract on spermatogenesis and testosterone levels in male diabetic rats

Rezaei AA, Salehi I, Karimi SA, Rahnama M

Objective: The strong antioxidant activity of Commiphora mukul prompted us to conduct the present study to explore whether treatment with C. mukul extract (CME) would have any protective influence on...
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Comparison of male reproductive parameters in mice with type 1 and type 2 diabetes

Sampannang A, Arun S, Burawat J, Sukhorum W, Iamsaard S

Objective: The differences between type 1 and type 2 diabetes mellitus (T1DM and T2DM) in terms of their adverse effects on male reproductive parameters have never been elucidated. This study...
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Protective Effects of Citicoline and Benfotiamine Each Alone and in Combination on Streptozotocin-induced Memory Impairment in Mice

Safavi M, Hosseini-Sharifabad A, Seyed-Yousefi Y, Rabbani M

Objective: Diabetes mellitus is associated with cognitive disorders such as Alzheimer’s disease. Studies have shown that citicoline and benfotiamine can improve memory and learning through different mechanism of actions. The...
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A comparison of metabolomic changes in type-1 diabetic C57BL/6N mice originating from different sources

Lee S, Kwak JH, Kim SH, Yun J, Cho JY, Kim K, Hwang D, Jung YS

Animal models have been used to elucidate the pathophysiology of varying diseases and to provide insight into potential targets for therapeutic intervention. Although alternatives to animal testing have been proposed...
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Growing pigs developed different types of diabetes induced by streptozotocin depending on their transcription factor 7-like 2 gene polymorphisms

Tu CF, Hsu CY, Lee MH, Jiang BH, Guo SF, Lin CC, Yang TS

The different polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene promote variances in diabetes susceptibility in humans. We investigated whether these genotypes also promote differences in diabetic susceptibility in...
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The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats

Safhi MM, Anwer T, Khan G, Siddiqui R, Moni Sivakumar S, Alam MF

The present study was carried out with the hypothesis that combination of canagliflozin and omega-3 fatty acid may have potential effect on insulin level, insulin resistance, cardiac biomarkers, inflammatory cytokines...
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Effects of cinnamic acid on memory deficits and brain oxidative stress in streptozotocin-induced diabetic mice

Hemmati AA, Alboghobeish S, Ahangarpour A

The present study aimed to evaluate the cinnamic acid effect on memory impairment, oxidative stress, and cholinergic dysfunction in streptozotocin (STZ)-induced diabetic model in mice. In this experimental study, 48...
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Anti-Diabetic Effect of Cotreatment with Quercetin and Resveratrol in Streptozotocin-Induced Diabetic Rats

Yang DK, Kang HS

Quercetin and resveratrol are known to have beneficial effects on the diabetes and diabetic complication, however, the effects of combined treatment of these compounds on diabetes are not fully revealed....
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Early changes in retinal structure and BMP2 expression in the retina and crystalline lens of streptozotocin-induced diabetic pigs

Jeong JS, Lee WK, Moon YS, Kim NR

PURPOSE: This study aims to evaluate early changes in retinal structure and BMP2 expression in the retina and crystalline lens by comparing streptozotocin-induced diabetic pigs and normal control group pigs. METHODS:...
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Comparison of the response using ICR mice derived from three different sources to multiple low-dose streptozotocin-induced diabetes mellitus

Lee DY, Kim MH, Suh HR, Jung YS, Hwang DY, Kim KS

This study was conducted to compare the multiple low-dose streptozotocin (MLDS)-induced diabetic patterns of Korl:ICR, A:ICR, and B:ICR mice obtained from three different sources. Six-week-old male ICR mice were obtained...
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Effects of Exercise on Neuropathy in Streptozotocin-Induced Diabetic Rats

Lee EC, Kim MO, Roh GH, Hong SE

OBJECTIVE: To evaluate the effects of early regular exercise and to assess the electrophysiological and histopathological findings of the rat tail nerve in relation to the timing of exercise training...
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Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells on Elastin Scaffold Remodeling in Diabetes

Chow JP, Simionescu DT, Carter AL, Simionescu A

Diabetes is a major risk factor for the progression of vascular disease, contributing to elevated levels of glycoxidation, chronic inflammation and calcification. Tissue engineering emerges as a potential solution for...
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Beneficial Effect of Lespedeza cuneata (G. Don) Water Extract on Streptozotocin-induced Type 1 Diabetes and Cytokine-induced Beta-cell Damage

Kim MS, Sharma BR, Rhyu DY

The aim of this study was to evaluate the anti-diabetic effects of the water extract of Lespedeza cuneata (LCW) using rat insulinoma (RIN) m5F cells and streptozotocin (STZ)-induced diabetic rats....
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The effects of dosage and the routes of administrations of streptozotocin and alloxan on induction rate of type1 diabetes mellitus and mortality rate in rats

Mostafavinia A, Amini A, Ghorishi S, Pouriran R, Bayat M

The approach and novelty of this scientific work was to formulate the appropriate Streptozotocin (STZ) and Alloxan dosage in different routes of administration to imply minimum mortality rate and high...
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